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Dolzhansky O.V.

Petrovsky Russian Research Center for Surgery, Moscow, Russia

Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Bukaeva A.A.

Academician B.V. Petrovsky Russian Research Center of Surgery, Moscow, Russia

Zakliaz'minskaia E.V.

FGBU RNTsKh im. akad. B.V. Petrovskogo RAMN

Solovyova S.E.

Department of Heart Valve Surgery Petrovsky Russian Research Center for Surgery, Moscow, Russia

Fedorov D.N.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

The morphological and molecular genetic characteristics of sarcomatoid chromophobe renal cell carcinoma

Authors:

Dolzhansky O.V., Pal'tseva E.M., Bukaeva A.A., Zakliaz'minskaia E.V., Solovyova S.E., Fedorov D.N.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2018;80(4): 39‑46

DOI: 10.17116/patol201880439

Views: 5166

Downloaded: 127

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To cite this article:

Dolzhansky OV, Pal'tseva EM, Bukaeva AA, Zakliaz'minskaia EV, Solovyova SE, Fedorov DN. The morphological and molecular genetic characteristics of sarcomatoid chromophobe renal cell carcinoma. Russian Journal of Archive of Pathology. 2018;80(4):39‑46. (In Russ.)
https://doi.org/10.17116/patol201880439

Подписка 2025 (Russian Journal of Archive of Pathology)
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The paper describes a case of chromophobe renal cell carcinoma growing into the muscular layer of the descending colon and with metastases in 4 lymph nodes of paranephral tissue in a 66-year-old woman. The tumor had a zonal structure with an alternation of epithelioid and sarcomatoid structural sites and with the signs of grades I, II and III according to the grading system by Paner and et al. (2010). The sarcomatoid renal component occupied about 70.0% of the tumor. There was a pronounced immunohistochemical reaction with VEGF-A (5 scores), a high Ki-67 proliferation index (70%), and a large number of tumor cells with nuclear p53 expression (85%) in the areas with minimal differentiation and sarcomatoid elements (Grade III). These signs can serve as criteria for the aggressive behavior of the tumor. A large volume of the sarcomatoid carcinoma component and a strong reaction with VEGF-A are indications for targeted therapy with anti-VEGF drugs.

Keywords:

chromophobe renal cell carcinoma
sarcomatoid differentiation
VEGF-A
targeted therapy

Authors:

Dolzhansky O.V.

Petrovsky Russian Research Center for Surgery, Moscow, Russia

Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Bukaeva A.A.

Academician B.V. Petrovsky Russian Research Center of Surgery, Moscow, Russia

Zakliaz'minskaia E.V.

FGBU RNTsKh im. akad. B.V. Petrovskogo RAMN

Solovyova S.E.

Department of Heart Valve Surgery Petrovsky Russian Research Center for Surgery, Moscow, Russia

Fedorov D.N.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

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