The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Oleynikova N.А.

Lomonosov Moscow State University, Moscow, Russia

Kharlova O.A.

Russian Medical Academy of Postgraduate Education, Moscow

Mal'kov P.G.

GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova";
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

The expression of claudins in colonic neoplasms

Authors:

Oleynikova N.А., Kharlova O.A., Mal'kov P.G., Danilova N.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2017;79(1): 28‑35

DOI: 10.17116/patol201779128-35

Read: 1235 times

Download PDF (RU)
Contact the author
Table of contents

THE EXPRESSION OF CLAUDINS IN COLONIC NEOPLASMS
THE EXPRESSION OF CLAUDINS IN COLONIC NEOPLASMS

To cite this article:

Oleynikova NА, Kharlova OA, Mal'kov PG, Danilova NV. The expression of claudins in colonic neoplasms. Russian Journal of Archive of Pathology. 2017;79(1):28‑35. (In Russ.)
https://doi.org/10.17116/patol201779128-35

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Characteristics and diagnostic value of preoperative biopsy in colo­rectal late­rally spreading tumors. Russian Journal of Evidence-Based Gastroenterology. 2024;(4):16-24
Comparative analysis of longitudinal and transverse mini­laparotomy during colon cancer surgery. Piro­gov Russian Journal of Surgery. 2025;(4):71-78
Ergo­spirometry for preoperative risk asse­ssment in patients with colo­rectal cancer. Russian Journal of Anesthesiology and Reanimatology. 2025;(3):70-77
Inte­rleukin-6 as a biochemical marker of inte­stinal anastomotic leakage. Piro­gov Russian Journal of Surgery. 2025;(9):87-93
Abstract:

Objective: the evaluation of localization claudin-1, -3 and -4 types of cancer and colon polyps. Material and methods. The study included 32 colon adenocarcinoma and 86 polyps. Antibody claudin-1; -3 and -4 were used as immunohistochemical markers in this study. Results. 84/118, 64/118, 52/118 reaction with claudin-1, claudin-3 and claudin-4 in cancer and colon polyps had a membrane localization, respectively. In 33 (27.9%) cases was found paradoxical reaction claudin-1; in 50 (42.4%) — a paradoxical reaction claudin-3 in 66 (55.9%) — a paradoxical reaction claudin-4. Among the paradoxical claudin reaction nuclear localization of marker was observed relatively rarely: claudin-3 in 2.5% cases of colon cancer; claudin-4 in 8.5% of colon polyps. Conclusion. Mislocalization claudin-3 to nucleus in colon cancer and mislocalization claudin-4 to nucleus in adenomas of the colon were detected for the first time. The potential reasons for the paradoxical expression are discussed and a review of the literature, related all the alleged mechanisms of this mislocalization is provided.

Keywords:

polyps of colon
colorectal cancer
claudins
nucleus
tight junctions

Authors:

Oleynikova N.А.

Lomonosov Moscow State University, Moscow, Russia

Kharlova O.A.

Russian Medical Academy of Postgraduate Education, Moscow

Mal'kov P.G.

GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova";
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Close metadata

References:

  1. Balda MS, Matter K. The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J. 2000;19(9):2024-2033. doi:10.1093/emboj/19.9.2024
  2. Soler AP, Miller RD, Laughlin KV, Carp NZ, Klurfeld DM, Mullin JM. Increased tight junctional permeability is associated with the development of colon cancer. Carcinogenesis. 1999;20(8):1425-1431.
  3. Singh AB, Sharma A, Dhawan P. Claudin family of proteins and cancer: an overview. J Oncol. 2010;2010:541957. doi:10.1155/2010/541957
  4. Huo Q, Kinugasa T, Wang L, Huang J, Zhao J, Shibaguchi H, et al. Claudin-1 protein is a major factor involved in the tumorigenesis of colorectal cancer. Anticancer Res. 2009;29(3):851-857.
  5. Lal-Nag M, Morin PJ. The claudins. Genome Biol. 2009;10(8):235. doi:10.1186/gb-2009-10-8-235
  6. Long H, Crean CD, Lee WH, Cummings OW, Gabig TG. Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium. Cancer Res. 2001;61(21):7878-7881.
  7. Michl P, Barth C, Buchholz M, Lerch MM, Rolke M, Holzmann KH, et al. Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer. Cancer Res. 2003;63(19):6265-6271.
  8. Rangel LB, Agarwal R, D'Souza T, Pizer ES, Alò PL, Lancaster WD, et al. Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res. 2003;9(7):2567-2575.
  9. Lu S, Singh K, Mangray S, Tavares R, Noble L, Resnick MB, Yakirevich E. Claudin expression in high-grade invasive ductal carcinoma of the breast: correlation with the molecular subtype. Mod Pathol. 2013;26(4):485-495. doi:10.1038/modpathol.2012.187
  10. Shibutani M, Noda E, Maeda K, Nagahara H, Ohtani H, Hirakawa K. Low expression of claudin-1 and presence of poorly-differentiated tumor clusters correlate with poor prognosis in colorectal cancer. Anticancer Res. 2013;33(8):3301-3306.
  11. Süren D, Yıldırım M, Kaya V, Alikanoğlu AS, Bülbüller N, Yıldız M, Sezer C. Loss of tight junction proteins (Claudin 1, 4, and 7) correlates with aggressive behavior in colorectal carcinoma. Med Sci Monit. 2014;20:1255-1262. doi:10.12659/msm.890598
  12. Sheehan GM, Kallakury BV, Sheehan CE, Fisher HA, Kaufman RP Jr, Ross JS. Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas. Hum Pathol. 2007;38(4):564-569. doi:10.1016/j.humpath.2006.11.007
  13. Matter K, Balda MS. Epithelial tight junctions, gene expression and nucleo-junctional interplay. J Cell Sci. 2007;120(9):1505-1511. doi:10.1242/jcs.005975
  14. Steed E, Balda MS, Matter K. Dynamics and functions of tight junctions. Trends Cell Biol. 2010;20(3):142-149. doi:10.1016/j.tcb.2009.12.002
  15. Niessen CM. Tight junctions/adherens junctions: basic structure and function. J Invest Dermatol. 2007;127(11):2525-2532. doi:10.1038/sj.jid.5700865
  16. Angelow S, Ahlstrom R, Yu AS. Biology of claudins. Am J Physiol Renal Physiol. 2008;295(4):F867-F876. doi:10.1152/ajprenal.90264.2008
  17. Gröne J, Weber B, Staub E, Heinze M, Klaman I, Pilarsky C, et al. Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8 and -12. Int J Colorectal Dis. 2007;22(6):651-659. doi:10.1007/s00384-006-0197-3
  18. Dhawan P, Singh AB, Deane NG, No Y, Shiou SR, Schmidt C, et al. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest. 2005;115(7):1765-1776. doi:10.1172/jci24543
  19. Soini Y. Claudins in lung diseases. Respir Res. 2011;12:70. doi:10.1186/1465-9921-12-70
  20. Cuevas ME, Gaska JM, Gist AC, King JM, Sheller RA, Todd MC. Estrogen-dependent expression and subcellular localization of the tight junction protein claudin-4 in HEC-1A endometrial cancer cells. Int J Oncol. 2015;47(2):650-656. doi:10.3892/ijo.2015.3030
  21. Fortier AM, Asselin E, Cadrin M. Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem. 2013;288(16):11555-11571. doi:10.1074/jbc.M112.428920
  22. French AD, Fiori JL, Camilli TC, Leotlela PD, O'Connell MP, Frank BP, et al. PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. Int J Med Sci. 2009;6(2):93-101.
  23. Jian Y, Chen C, Li B, Tian X. Delocalized Claudin-1 promotes metastasis of human osteosarcoma cells. Biochem Biophys Res Commun. 2015;466(3):356-361. doi:10.1016/j.bbrc.2015.09.028
  24. Leotlela PD, Wade MS, Duray PH, Rhode MJ, Brown HF, Rosenthal DT, et al. Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility. Oncogene. 2007;26(26):3846-3856. doi:10.1038/sj.onc.1210155
  25. Todd MC, Petty HM, King JM, Piana Marshall BN, Sheller RA, Cuevas ME. Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB-415 breast cancer cell lines. Oncol Lett. 2015;10(1):156-162. doi:10.3892/ol.2015.3160
  26. Zhou B, Moodie A, Blanchard AA, Leygue E, Myal Y. Claudin 1 in breast cancer: new insights. J Clin Med. 2015;4(12):1960-1976. doi:10.3390/jcm4121952
  27. Rüffer C, Gerke V. The C-terminal cytoplasmic tail of claudins 1 and 5 but not its PDZ-binding motif is required for apical localization at epithelial and endothelial tight junctions. Eur J Cell Biol. 2004;83(4):135-144. doi:10.1078/0171-9335-00366
  28. Kwon MJ. Emerging roles of claudins in human cancer. Int J Mol Sci. 2013;14(9):18148-18180. doi:10.3390/ijms140918148
  29. Merino-Gracia J, Costas-Insua C, Canales MÁ, Rodríguez-Crespo I. Insights into the c-terminal peptide binding specificity of the pdz domain of neuronal nitric-oxide synthase: Characterization of the interaction with the tight junction protein claudin-3. J Biol Chem. 2016;291(22):11581-11595. doi:10.1074/jbc.M116.724427
  30. Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 2008;1778(3):660-669. doi:10.1016/j.bbamem.2007.07.012
  31. Kausalya PJ, Phua DC, Hunziker W. Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF. Mol Biol Cell. 2004;15(12):5503-5515. doi:10.1091/mbc.E04-04-0350
  32. Fabbro M, Rodriguez JA, Baer R, Henderson BR. BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export. J Biol Chem. 2002;277(24):21315-21324. doi:10.1074/jbc.M200769200
  33. Reilly JF, Maher PA. Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferation. J Cell Biol. 2001;152(6):1307-1312.
  34. Balda MS, Garrett MD, Matter K. The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Biol. 2003;160(3):423-432. doi:10.1083/jcb.200210020
  35. Reichert M, Müller T, Hunziker W. The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells. Evidence for a role of beta-catenin/Tcf/Lef signaling. J Biol Chem. 2000;275(13):9492-9500.
  36. Torres-Flores JM, Arias CF. Tight Junctions Go Viral! Viruses. 2015;7(9):5145-5154. doi:10.3390/v7092865
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.