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Rzheutskaya R.E.

Almazov National Medical Research Centre

Bautin A.E.

Almazov National Medical Research Center

Sonkin I.N.

Russian Railway — Medicine Hospital

Umnova N.S.

Almazov National Medical Research Centre

Mazurok V.A.

Almazov North-Western Federal Medical Research Center

Efficacy and safety of balanced infusion therapy in elective abdominal and pelvic surgery

Authors:

Rzheutskaya R.E., Bautin A.E., Sonkin I.N., Umnova N.S., Mazurok V.A.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2025;(6): 44‑50

DOI: 10.17116/anaesthesiology202506144

Read: 651 times

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Table of contents

EFFICACY AND SAFETY OF BALANCED INFUSION THERAPY IN ELECTIVE ABDOMINAL AND PELVIC SURGERY
EFFICACY AND SAFETY OF BALANCED INFUSION THERAPY IN ELECTIVE ABDOMINAL AND PELVIC SURGERY

To cite this article:

Rzheutskaya RE, Bautin AE, Sonkin IN, Umnova NS, Mazurok VA. Efficacy and safety of balanced infusion therapy in elective abdominal and pelvic surgery. Russian Journal of Anesthesiology and Reanimatology. 2025;(6):44‑50. (In Russ.)
https://doi.org/10.17116/anaesthesiology202506144

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Abstract:

OBJECTIVE

To evaluate blood electrolyte and acid-base balance in perioperative period of elective abdominal and pelvic surgeries depending on infusion therapy.

MATERIAL AND METHODS

Seventy-two patients scheduled for abdominal or pelvic surgery were randomly assigned to receive balanced (Gelaspan combined with Sterofundin ISO) or unbalanced (Gelofusine combined with 0.9% NaCl) infusion therapy. Conventional perioperative monitoring was performed. In addition, acid-base balance was assessed at three points: 1) before induction, 2) at the end of surgery, and 3) 12 hours after surgery. We analyzed gas composition and biochemical parameters in arterial blood taken from radial artery.

RESULTS

At the end of surgery, more pronounced acidosis (decreased BE, pH, and HCO3-) was determined after unbalanced infusion therapy. After 12 postoperative hours, unbalanced infusion therapy was followed by significantly higher serum chlorides and lower BE.

CONCLUSION

Administration of Gelaspan and Sterofundin ISO keeps normal acid-base balance in patients with ASA grade II/III undergoing elective open abdominal or pelvic surgery. At the same time, mild metabolic acidosis and higher serum chloride levels were observed after administration of Gelofusine and 0.9% NaCl.

Keywords:

infusion therapy
balanced solutions
crystalloids
colloids
metabolic acidosis

Authors:

Rzheutskaya R.E.

Almazov National Medical Research Centre

Bautin A.E.

Almazov National Medical Research Center

Sonkin I.N.

Russian Railway — Medicine Hospital

Umnova N.S.

Almazov National Medical Research Centre

Mazurok V.A.

Almazov North-Western Federal Medical Research Center

Received:

05.06.2025

Accepted:

05.06.2025

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