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Potievskaya V.I.

Herzen Moscow Research Oncological Institute — Branch of the National Medical Research Center of Radiology

Zabolotskikh I.B.

Kuban State Medical University

Gridchik I.E.

Russian Medical Academy for Continuous Professional Education

Gritsan A.I.

Voyno-Yasenetsky Krasnoyarsk State Medical University

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

Kozlov I.A.

Moscow Regional Research Clinical Institute n.a. M.F. Vladimirskiy

Lebedinskii K.M.

North-Western State Medical University n.a. Mechnikov, Federal Research;
Clinical Center of Intensive Care Medicine and Rehabilitology

Levit A.L.

Sverdlovsk Regional Clinical Hospital No. 1

Mazurok V.A.

Almazov National Medical Research Center

Molchanov I.V.

Russian Medical Academy for Continuous Professional Education

Nikolaenko E.M.

Central Clinical Hospital «Russian Railways Medicine»

Sedation of patients in intensive care units

Authors:

Potievskaya V.I., Zabolotskikh I.B., Gridchik I.E., Gritsan A.I., Eremenko A.A., Kozlov I.A., Lebedinskii K.M., Levit A.L., Mazurok V.A., Molchanov I.V., Nikolaenko E.M.

More about the authors

Journal: Russian Journal of Anesthesiology and Reanimatology. 2020;(5): 7‑22

DOI: 10.17116/anaesthesiology20200517

Read: 94452 times

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Table of contents

SEDATION OF PATIENTS IN INTENSIVE CARE UNITS
SEDATION OF PATIENTS IN INTENSIVE CARE UNITS

To cite this article:

Potievskaya VI, Zabolotskikh IB, Gridchik IE, et al. . Sedation of patients in intensive care units. Russian Journal of Anesthesiology and Reanimatology. 2020;(5):7‑22. (In Russ.)
https://doi.org/10.17116/anaesthesiology20200517

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Abstract:

The guidelines for sedation of patients in intensive care units (ICU) are presented in the article. Indications for sedative therapy, main tasks and approaches to sedation are highlighted. Principles of sedative medications selection, characteristics of effects and adverse reactions of sedative drugs are presented. Tactics for sedation in critically ill patients including patients with hypoxic encephalopathy is described. Recommendations on prophylaxis of agitation in patients in ICU are set out. Basic criteria of medical care quality control are presented.

Keywords:

sedation
mechanical lung ventilation
intensive care unit
anesthesiology unit
sedative drugs
posthypoxic encephalopathy

Authors:

Potievskaya V.I.

Herzen Moscow Research Oncological Institute — Branch of the National Medical Research Center of Radiology

Zabolotskikh I.B.

Kuban State Medical University

Gridchik I.E.

Russian Medical Academy for Continuous Professional Education

Gritsan A.I.

Voyno-Yasenetsky Krasnoyarsk State Medical University

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

Kozlov I.A.

Moscow Regional Research Clinical Institute n.a. M.F. Vladimirskiy

Lebedinskii K.M.

North-Western State Medical University n.a. Mechnikov, Federal Research;
Clinical Center of Intensive Care Medicine and Rehabilitology

Levit A.L.

Sverdlovsk Regional Clinical Hospital No. 1

Mazurok V.A.

Almazov National Medical Research Center

Molchanov I.V.

Russian Medical Academy for Continuous Professional Education

Nikolaenko E.M.

Central Clinical Hospital «Russian Railways Medicine»

Close metadata

References:

  1. Riker RR, Fraser GL. Altering intensive care sedation paradigms to improve patient outcomes. Crit Care Clin. 2009;25:527-538.  https://doi.org/10.1016/j.ccc.2009.05.004
  2. The San Diego Patient Safety Council. ICU Sedation Guidelines of Care. 2009.
  3. Fraser GL, Prato BS, Riker RR, Berthiaume D, Wilkins ML. Evaluation of agitation in ICU patients: Incidence, severity, and treatment in the young versus the elderly. Pharmacotherapy. 2000;20:75-82. 
  4. Belda JF, Soro M, Badenes R, et al. The predictive performance of a pharmacokinetic model for manually adjusted infusion of liquid sevoflurane for use with the Anesthetic-Conserving Device (AnaConDa): a clinical study. Anesth Analg. 2008;106:1207-1214. https://doi.org/10.1213/ane.0b013e31816782ff
  5. Textbook of critical care. Ed. Vincent J.L. et al. 6th ed.; 2013.
  6. DeBiasi EM, Akgün KM, Pisani M. Trends in the Evaluation and Management of Agitation in the ICU. Semin Respir Crit Care Med. 2015;36:899-913.  https://doi.org/10.1055/s-0035-1564875
  7. Devlin JW, Fraser GL, Ely W, Kress JP, et al. Pharmacological Management of Sedation and Delirium inMechanically Ventilated ICU Patients: Remaining Evidence Gaps and Controversies. Semin Respir Crit Care Med. 2013; 34:201-215.  https://doi.org/10.1055/s-0033-1342983
  8. Kozlov IA. Modern approaches to sedation in intensive care units. Meditsinskij alfavit. Neotlozhnaya meditsina. 2013;1:22-31. (In Russ.).
  9. Rivosecchi RM, Kane-Gill SL, Svec S, et al. The implementation of a nonpharmacologic protocol to prevent intensive care delirium. J Crit Care. 2016;31:206-211.  https://doi.org/10.1016/j.jcrc.2015.09.031
  10. Shehabi Y, Chan L, Kadiman S, et al. Sedation Practice in Intensive Care Evaluation (SPICE) Study Group Investigators: Sedation depth and long-term mortality in mechanically ventilated critically ill adults: A prospective longitudinal multicentre cohort study. Intensive Care Med. 2013;39:910-918.  https://doi.org/10.1007/s00134-013-2830-2
  11. Yang KS, Habib AS, Lu M, et al. A prospective evaluation of the incidence of adverse events in nurse-administered moderate sedation guided by sedation scores or bispectral index. Anesth Analg. 2014;119:4348. https://doi.org/10.1213/ane.0b013e3182a125c3
  12. Shehabi Y, Bellomo R, Reade MC, et al. Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators; ANZICS Clinical Trials Group: Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med. 2012;186:724-731.  https://doi.org/10.1164/rccm.201203-0522oc
  13. Ovechkin AM, Korienko PA, Zabolotskikh IB, Uvarov DN. Anal’geziya i sedatsiya v intensivnoj terapii. Intensivnaya terapiya. Kratkoe izdanie. Gelfand BR, Zabolotskikh IB, eds. M.: GEOTAR-Media; 2017. (In Russ.).
  14. Walsh T, Kydonaki K, Antonelli J, et al. Rationale, design and methodology of a trial evaluating three strategies designed to improve sedation quality in intensive care units (DESIST study). BMJ Open. 2016;6(3):e010148. https://doi.org/10.1136/bmjopen-2015-010148
  15. Treggiari M. Randomized trial of light versus deep sedation on mental health after critical illness. Crit Care Med. 2010;38(1):349-350.  https://doi.org/10.1097/ccm.0b013e3181c546f8
  16. Cohen D, Horiuchi K, Kemper M, et al. Modulating effects of propofol on metabolic and cardiopulmonary responses to stressful intensive care unit procedures. Crit Care Med. 1996;24:612-617.  https://doi.org/10.1097/00003246-199604000-00011
  17. Vincent JL, Shehabi Y, Walsh TS, Pandharipande PP, et al. Comfort and patient-centred care without excessive sedation: the eCASH concept. Intensive Care Med. 2016;42:962-971.  https://doi.org/10.1007/s00134-016-4297-4
  18. DAS-Taskforce 2015, Baron R, Binder A, Biniek R, Braune S, Buerkle H, et al. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) — short version. Ger Med Sci. 2015;13:Doc19.
  19. Oddo M, Crippa IA, Mehta S, Menon D, Payen J-F, Taccone FS, Citerio G. Optimizing sedation in patients with acute brain injury. Critical Care. 2016;20:128.  https://doi.org/10.1186/s13054-016-1294-5
  20. Papazian L, Forel JM, Gacouin A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363:1107-1116. https://doi.org/10.1056/nejmoa1005372
  21. Opdenakker O, Vanstraelen A, De Sloovere V, Meyfroidt G. Sedatives in neurocritical care: an update on pharmacological agents and modes of sedation. Curr Opin Crit Care. 2019;25(2):97-104.  https://doi.org/10.1097/mcc.0000000000000592
  22. Tanaka, et al. Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study. Critical Care. 2014;18:R156. https://doi.org/10.1186/cc13995
  23. Shah FA, Girard TD, Yende S. Limiting sedation for patients with acute respiratory distress syndrome — time to wake up. Curr Opin Crit Care. 2017;23:45-51.  https://doi.org/10.1097/mcc.0000000000000382
  24. Brattebo G, Hofoss D, Flaatten H, et al. Effect of a scoring system and protocol for sedation on duration of patients’ need for ventilator support in a surgical intensive care unit. BMJ. 2002;324:1386-1389. https://doi.org/10.1136/qhc.13.3.203
  25. Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale: Validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med. 2002;166:1338-1344. https://doi.org/10.1164/rccm.2107138
  26. Lu CH, Ou-Yang HY, Man KM, et al. Relative reliability of the auditory evoked potential and bispectral index for monitoring sedation level in surgical intensive care patients. Anaesth Intensive Care. 2008;36:553-559.  https://doi.org/10.1177/0310057x0803600409
  27. Wang ZH, Chen H, Yang YL, et al. Bispectral index can reliably detect deep sedation in mechanically ventilated patients: A prospective multicenter validation study. Anesth Analg. 2017;125:176-183.  https://doi.org/10.1213/ane.0000000000001786
  28. Chisholm CJ, Zurica J, Mironov D, et al. Comparison of electrophysiologic monitors with clinical assessment of level of sedation. Mayo Clin Proc. 2006;81:46-52.  https://doi.org/10.4065/81.1.46
  29. Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): A randomised controlled trial. Lancet. 2008;371:126-134.  https://doi.org/10.1016/s0734-3299(08)79079-8
  30. Page VJ, McAuley DF. Sedation/drugs used in intensive care sedation. Curr Opin Anesthesiol. 2015;28:139-144.  https://doi.org/10.1097/aco.0000000000000174
  31. Foster J, Kelly M. A pilot study to test the feasibility of a nonpharmacologic intervention for the prevention of delirium in the medical intensive care unit. Clin Nurse Spec. 2013;27:231-238.  https://doi.org/10.1097/nur.0b013e3182a0b9f9
  32. Jakob SM, Ruokonen E, Grounds RM, et al. Dexmedetomidine vs midozalam or propofol for sedation during prolonged mechanical ventilation. JAMA. 2012;307:11:1151-1160. https://doi.org/10.1001/jama.2012.304
  33. Keating GM, Sheritan MH, Williamson KA. Dexmedetomidin: a guide to its use for sedation in the US. Clin Drug Investig. 2012;32(8):561-567.  https://doi.org/10.1007/bf03261910
  34. Yuan X, Wu J, Wmoang Q, Xu M. The antinociceptive effect of systemic administration of a combination of low-dose tramadol and dexmedetomidine in a rat model of bone cancer pain. Eur J Anaesthesiol. 2014;31:30-34.  https://doi.org/10.1097/eja.0b013e3283624a0f
  35. Brumett CM, Hong EK, Janda AM, et al. Perineural dexmedetomidine added to roopivacaine for sciatic nerve block in rats prolongs the duration of an- algesia by blocking the hyperpolarization-activated cation current. Anesthesiology. 2011;115:836-843.  https://doi.org/10.1097/aln.0b013e318221fcc9
  36. Ugur F, Gilcu N, Boyaci A. Intrathecal infusion therapy with dexmedetomidine-supplemented morphine in cancer pain. Acta Anaeshesiol Scand. 2007;51:388.  https://doi.org/10.1111/j.1399-6576.2006.01202.x
  37. Dexdor: public assessment report. London: European Medicines Agency, 2011 Oct 4. 
  38. Hoy SM, Keating JM. Dexmedetomidine: a review of its use for sedation in mechanically ventilated patients in an intensive care setting and for procedural sedation. Drugs. 2011;71(11):1481-1501. https://doi.org/10.1007/s40265-015-0419-5
  39. Li B, Wang H, Wu H, Gao C. Neurocognitive Dysfunction Risk Alleviation With the Use of Dexmedetomidine in Perioperative Conditions or as ICU. Sedation Medicine. 2015;94:1-9.  https://doi.org/10.1097/md.0000000000000597
  40. Reede MS, O’Sullivan K, Bates S, et al. Dexmedetomidine versus galoperi- dol in delirious, agitated, intubated patients: a randomized open-label trial. Crit Care. 2009;13(3):75-84.  https://doi.org/10.1186/cc7890
  41. Kozlov IA, Krichevsky LA. Dexmedetomidin for sedation of cardiosurgical patients. Patologiya krovoobrashcheniya i kardiokhirurgiya. 2014;3:67-75. (In Russ.). https://doi.org/10.21688/1681-3472-2014-3-67-75
  42. Constantin J-M, Momon A, Mantz J, Payen J-F, et al. Efficacy and safety of sedation with dexmedetomidine in critical care patients: A meta-analysis of randomized controlled trials. Anaesth Crit Care Pain Med (2015), Zhang Z. et al. Sedation of mechanically ventilated adults in intensive care unit: a network meta-analysis. Sci Rep. 2017;7:44979. https://doi.org/10.1038/srep44979
  43. Nikoda VV, Bondarenko AV, Dubov VA. Clinical use of dexmedetomidine in patients after thoracic-abdominal surgery. Anesteziologiya i reanimatologiya. 2014;5:16-21. (In Russ.).
  44. Nikoda VV, Gritsan AI, Eremenko AA, et al. Effectiveness and safety of dexmedetomidine use for sedation of patients during prolonged mechanical lung ventilation in intensive care units. Anesteziologiya i reanimatologiya. 2015;5:47-55. (In Russ.).
  45. Rubinchik VE, Kasherininov IYu, Bautin AE. Treatment of delirium in early postoperative cardiosurgical patients. Vestnik intensivnoj terapii imeni A.I. Saltanova. 2019;3:77-83. (In Russ.). https://doi.org/10.21320/1818-474x-2019-3-77-83
  46. Gruzdev KA, Margolina AA, Tabakyan EA, Lepilin MG. Dexmedetomidine sedation experience in hybrid cardiac operations. Vestnik intensivnoj terapii imeni A.I. Saltanova. 2019;3:69-76. (In Russ.). https://doi.org/10.21320/1818-474x-2019-3-69-76
  47. Jörg M, Axel P, Franck M, et al. Practice of sedation and analgesia in German intensive care units: results of a national survey. Critical Care. 2006; 9(2):117-123.  https://doi.org/10.1007/s00134-006-0214-6
  48. Cormack JR, Orme RM, Costello TG. The role of α2-agonists in neurosurgery. J Clin Sci. 2005;12(4):375-378.  https://doi.org/10.1016/j.jocn.2004.06.008
  49. Jing Wang, Belley-Coté E, Burry L, Duffett M, et al. Clonidine for sedation in the critically ill: a systematic review and meta-analysis (protocol). Systematic Reviews. 2015;4:154.  https://doi.org/10.1186/s13643-015-0139-7
  50. Mirski MA, Hemstreet MK. Critical care sedation for neuroscience patients. J Neurosurg Sci. 2007;261:16-34.  https://doi.org/10.1016/j.jns.2007.04.028
  51. McKeage K, Perry CM. Propofol: A review of its use in intensive care sedation of adults. CNS Drugs. 2003;17:235-272.  https://doi.org/10.2165/00023210-200317040-00003
  52. Carson SS, Kress JP, Rodgers JE, et al. A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med. 2006;34:1326-1332. https://doi.org/10.1097/01.ccm.0000215513.63207.7f
  53. Barr J, Egan TD, Sandoval NF, et al. Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model. Anesthesiology. 2001;95:324-333.  https://doi.org/10.1097/00132586-200208000-00014
  54. Riker RR, Fraser GL. Adverse events associated with sedatives, analgesics, and other drugs that provide patient comfort in the intensive care unit. Pharmacotherapy. 2005;25(5 Pt 2):8-18.  https://doi.org/10.1592/phco.2005.25.5_part_2.8s
  55. Walder B, Tramèr MR, Seeck M. Seizure-like phenomena and propofol: a systematic review. Neurology. 2002;58:1327-1332. https://doi.org/10.1212/wnl.58.9.1327
  56. Iyer VN, Hoel R, Rabinstein AA. Propofol infusion syndrome in patients with refractory status epilepticus: An 11-year clinical experience. Crit Care Med. 2009;37:3024-3030. https://doi.org/10.1097/ccm.0b013e3181b08ac7
  57. Parviainen I, Uusaro A, Kälviäinen R, et al. Propofol in the treatment of refractory status epilepticus. Intensive Care Med. 2006;32:1075-1079. https://doi.org/10.1007/s00134-006-0154-1
  58. Voss LJ, Sleigh JW, Barnard JP, et al. The howling cortex: Seizures and general anesthetic drugs. Anest Analg. 2008;107:1689-1703. https://doi.org/10.1213/ane.0b013e3181852595
  59. Fong JJ, Sylvia I, Barnard JP, et al. Predictors of mortality in patients with suspected propofol infusion syndrome. Crit Care Med. 2008;36:2281-2287. https://doi.org/10.1097/ccm.0b013e318180c1eb
  60. Didrich DA, Brown DR. Analytic reviews: Propofol infusion syndrome in ICU. J Intensive Care Med. 2011;26:59-72.  https://doi.org/10.1177/0885066610384195
  61. Merz TM, Regli B, Roten HU, et al. Propofol infusion syndrome: a fatal case at a low infusion rate. Anesth Analg. 2006;103:1050. https://doi.org/10.1213/01.ane.0000239080.82501.c7
  62. Chukwuemeka A, Ko R, Ralf-Edwards A. Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis. Anaesth Intensive Care. 2006;34:651-655.  https://doi.org/10.1177/0310057x0603400503
  63. Roberts RJ, Barletta JF, Fong JJ, et al. Incidence of propofol-related infusion syndrome in critically ill adults: A prospective, multicenter study. Crit Care. 2009;13:169.  https://doi.org/10.1186/cc8145
  64. Barr J, Zomorodi K, Bertaccini EJ et al. A double-blind, randomized comparison of i.v. lorazepam versus midazolam for sedation of ICU patients via a pharmacologic model. Anesthesiology. 2001;95:286-298.  https://doi.org/10.1097/00000542-200108000-00007
  65. Shafer A. Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Crit Care Med. 1998;26:947-956.  https://doi.org/10.1097/00003246-199805000-00034
  66. Swart EL, Zuideveld KP, de Jongh J, et al. Population pharmacodynamics modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients. Eur J Clin Pharmacol. 2006;62:185-194. 
  67. Swart EL, de Jongh J, Zuideveld KP, et al. Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous veno-venous hemofiltration. Am J Kidney Dis. 2005;45:360-371.  https://doi.org/10.1007/s00228-005-0085-8
  68. Swart EL, Zuideveld KP, de Jongh J, et al. Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients. Br J Clin Pharmacol. 2004;57:135-145.  https://doi.org/10.1046/j.1365-2125.2003.01957.x
  69. Ariano RE, Kassum DA, Aronson KJ. Comparison of sedative recovery time after midazolam versus diazepam administration. Crit Care Med. 1994; 22:1492-1496. https://doi.org/10.1046/j.1365-2125.2003.01957.x
  70. Shruti B Patel, John P. Kress. Sedation and Analgesia in the Mechanically Ventilated Patient. Am J Resp and Crit Care Med. 2012;185(5):486-497.  https://doi.org/10.1164/rccm.201102-0273ci
  71. Zhou Y, Jin X, Kang Y, et al. Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients: A prospective, randomized study. Crit Care. 2014;18:R122. https://doi.org/10.1186/isrctn01173443
  72. Srivastava VK, Agrawal S, Kumar S, et al. Comparison of dexmedetomidine, propofol and midazolam for short-term sedation in postoperatively mechanically ventilated neurosurgical patients. J Clin Diagn Res. 2014;8:GC04GC07. https://doi.org/10.7860/jcdr/2014/8797.4817
  73. De Hert SG, van der Linden PJ, Cromheecke S, et al. Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration. Anesthesiology. 2004;101:299-310.  https://doi.org/10.1097/00000542-200503000-00046
  74. Hellstrom J, Owall A, V. Sackey PV. Cardiac outcome after sevoflurane versus propofol sedation following coronary bypass surgery: a pilot study. Acta Anaesthesiol Scand. 2011;55:460-467.  https://doi.org/10.1111/j.1399-6576.2011.02405.x
  75. Soro M, Gallego L, Silva V, et al. Sevoflurane and propofol during anaesthesia and the postoperative period in coronary bypass graft surgery: a double-blind randomized study. Eur J Anaesthesiol. 2012;29:1-9.  https://doi.org/10.1097/eja.0b013e3283560aea
  76. Bellgardt M, Bomberg H, Herzog-Niescery J, et al. Survival after long-term isoflurane sedation as opposed to intravenous sedation in critically ill surgical patients. Eur J Anaesthesiol. 2015;32:1-8.  https://doi.org/10.1097/eja.0000000000000252
  77. Mesnil M, Capdevila X, Bringuier S, et al. Long-term sedation in intensive care unit: a randomized comparison between ihaled sevoflurane and intravenous propofol or midazolam. Intensive Care Med. 2011;37:933-941.  https://doi.org/10.1007/s00134-011-2187-3
  78. Soro M, Belda FJ, Badenes R, Alcantara MJ. Use of the Ana Con Da (Anestesia Conserving Device) with sevoflurane in critical care patients. Eur J Anaesthesiol. 2004;21(Suppl 32):708a. https://doi.org/10.1097/00003643-200406002-00216
  79. Jerath A, Beattie SW, Chandy T, Karski J, Djaiani G, Rao V, Yau T, Wasowicz M. Volatile-based short-term sedation in cardiac surgical patients: a prospective randomized controlled trial. Crit Care Med. 2015;43:1062-1069. https://doi.org/10.1097/ccm.0000000000000938
  80. Skrobik Y, Ahern S, Leblanc M, Marquis F, Awissi DK, Kavanagh BP. Protocolized Intensive Care Unit Management of Analgesia, Sedation, and Delirium Improves Analgesia and Subsyndromal Delirium Rates. Anesthesia & Analgesia. Ovid Technologies (Wolters Kluwer Health). 2010;111(2):451-463.  https://doi.org/10.1213/ane.0b013e3181d7e1b8
  81. Meiser A, Sirtl C, Bellgardt M, Lohmann S, Garthoff A, Kaiser J, et al. Desflurane compared with propofol for postoperative sedation in the intensive care unit. British Journal of Anaesthesia. Elsevier BV. 2003;90(3):273-280.  https://doi.org/10.1093/bja/aeg059
  82. Kim HY, Lee JE, Kim HY, Kim J. Volatile sedation in the intensive care unit. Medicine. Ovid Technologies (Wolters Kluwer Health). 2017;96(49):e8976. https://doi.org/10.1097/md.0000000000008976 Dec; 96(49).
  83. Burov NE. Understanding of the mechanism of xenon action. Anesteziologiya i reanimatologiya. 2011;2:58-62. (In Russ).
  84. Stryapko NV, Sazontova TG, Potievskaya VI, Khairullina AA, Vdovina IB, Kulikov AN, Arkhipenko YuV, Molchanov IV. Adaptation Effect of Repeated Xenon Application. Obshchaya reanimatologiya. 2014;10(2):50-56. (In Russ.). https://doi.org/10.15360/1813-9779-2014-2-50-56
  85. Liu W, Liu Y, Chen H, Liu K, Tao H, Sun X. Xenon preconditioning: molecular mechanisms and biological effects. Medical Gas Research. Springer Science and Business Media LLC. 2013;3(1):3.  https://doi.org/10.1186/2045-9912-3-3
  86. Glumcher FS, Strepetova EV, Perebijnis MV, Mukhomorov AE. BIS-monitoring of curative xenon narcosis in intensive care clinic. Xenon and inert gases in medicine. Materialy III konferentsii anesteziologov-reanimatologov meditsinskikh uchrezhdenij MO RF. Moskva, 27 aprelya 2012:63-66. (In Russ.).
  87. Potievskaya V, Molchanov I, Krivenko T. Volatile anaesthetics for analgesia and sedation in patients after abdominal surgery in ICU. Intensive Care Medicine Experimental. Springer Science and Business Media LLC. 2015;3(1). https://doi.org/10.1186/2197-425x-3-s1-a329
  88. Dale CR, Kannas DA, Fan VS, Daniel SL, Deem S, Yanez ND, et al. Improved Analgesia, Sedation, and Delirium Protocol Associated with Decreased Duration of Delirium and Mechanical Ventilation. Annals of the American Thoracic Society. American Thoracic Society. 2014;11(3):367-374.  https://doi.org/10.1513/annalsats.201306-210oc
  89. Sandimenge A. Sedation of ventilated patients and analgesia. Clin Pulm Med. 2010;17(6):290-299.  https://doi.org/10.1097/cpm.0b013e3181fa1613
  90. Alekseeva GV, Gurvich AM, Semchenko VV. Post resuscitation encephalopathy (pathogenesis, clinic, prophylaxis and treatment). 2-e izd., dop. i pererab. Omsk: Omskaya oblastnaya tipografiya; 2002. (In Russ.).
  91. Alekseeva GV, Molchanov IV, Semchenko VV. Clinical neurology and intensive care of post resuscitation damage of nervous system (acute period). Posobie dlya vrachej (utv. Uchenym Sovetom MZ i SRRF). 2006:26. (In Russ.).
  92. University of Virginia Health System. Level I. Trauma Center. Trauma Handbook. 2012:141. 
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