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Kuznetsova L.V.

Research Institute of General Pathology and Pathophysiology

Karpova M.N.

Research Institute of General Pathology and Pathophysiology

Klishina N.Yu.

Research Institute of General Pathology and Pathophysiology

Kukushkin M.L.

Research Institute of General Pathology and Pathophysiology

Effect of cold stress on pain sensitivity in rats

Authors:

Kuznetsova L.V., Karpova M.N., Klishina N.Yu., Kukushkin M.L.

More about the authors

Journal: Russian Journal of Pain. 2023;21(3): 5‑10

DOI: 10.17116/pain2023210315

Views: 1116

Downloaded: 24

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Table of contents

EFFECT OF COLD STRESS ON PAIN SENSITIVITY IN RATS
EFFECT OF COLD STRESS ON PAIN SENSITIVITY IN RATS

To cite this article:

Kuznetsova LV, Karpova MN, Klishina NYu, Kukushkin ML. Effect of cold stress on pain sensitivity in rats. Russian Journal of Pain. 2023;21(3):5‑10. (In Russ.)
https://doi.org/10.17116/pain2023210315

Подписка 2025-2 (Russian Journal of Pain)
МСФ на ЯМ
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OBJECTIVE

To study individual changes of pain response in male Wistar rats under cold stress.

RESULTS

We found multidirectional changes of pain response thresholds under cold stress. Most of the animals (11 out of 17) developed stress-induced hyperalgesia, 6 animals — stress-induced analgesia.

CONCLUSION

Individual changes of pain sensitivity under cold stress can be used as a prognostic test to identify predisposition of animals to chronic pain.

Keywords:

pain response threshold
cold stress
rats

Authors:

Kuznetsova L.V.

Research Institute of General Pathology and Pathophysiology

Karpova M.N.

Research Institute of General Pathology and Pathophysiology

Klishina N.Yu.

Research Institute of General Pathology and Pathophysiology

Kukushkin M.L.

Research Institute of General Pathology and Pathophysiology

Received:

15.07.2023

Accepted:

18.07.2023

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