Login
EN
Phones:
+7 (495) 482-41-18
+7 (495) 482-43-29

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

E.G. Solonitsyn

Almazov National Medical Research Center

A.V. Poddymova

Almazov National Medical Research Centre

V.F. Kamalova

Almazov National Medical Research Centre

T.M. Shestopalova

Almazov National Medical Research Centre

L.B. Mitrofanova

Almazov National Medical Research Centre

S.Sh. Seyfedinova

Almazov National Medical Research Centre

A.A. Shpomer

Almazov National Medical Research Centre

Journal: Endoscopic Surgery. 2023;29(6): 19–27

Endoscopic ultrasonography and endoscopic ultrasonography with fine needle aspiration in the diagnosis of neuroendocrine neoplasms of the pancreas

Authors:

E.G. Solonitsyn, A.V. Poddymova, V.F. Kamalova, T.M. Shestopalova, L.B. Mitrofanova, S.Sh. Seyfedinova, A.A. Shpomer

More about the authors

DOI: 10.17116/endoskop20232906119

Read: 3370 times

Download PDF
Download PDF (RU)
Contact the author
Table of contents

Open to cite this article

Solonitsyn EG, Poddymova AV, Kamalova VF, Shestopalova TM, Mitrofanova LB, Seyfedinova SSh, Shpomer AA. Endoscopic ultrasonography and endoscopic ultrasonography with fine needle aspiration in the diagnosis of neuroendocrine neoplasms of the pancreas. Endoscopic Surgery. 2023;29(6):19‑27. (In Russ., In Engl.).
https://doi.org/10.17116/endoskop20232906119

Close metadata
Recommended articles:
Neuroendocrine tumor of the paro­tid gland with multiple asynchronous meta­stases to the right frontal sinus and scalp. Russian Rhinology. 2025;(3):255-260
Cystic-solid transformation of the pancreas and kidneys due to von Hippel-Lindau disease. Piro­gov Russian Journal of Surgery. 2025;(10):118-125
Cefo­perazone/sulbactam-induced coagulopathy following pancreatic surgery. Piro­gov Russian Journal of Surgery. 2026;(6):98-103
Inte­raction of gona­dotropin-releasing hormone with the gastrointestinal tract: expe­rimental and clinical perspectives. Russian Journal of Evidence-Based Gastroenterology. 2026;(2):43-52
Morphometric and topo­graphic-anatomical characterization of the dorsal pancreatic artery: rela­tionship with pancreatic volume, age, and branching pattern. Russian Journal of Operative Surgery and Clinical Anatomy. 2026;(2-2):80-87
Intraductal onco­cytic papi­llary neoplasm of the pancreas. Russian Journal of Archive of Pathology. 2026;(4):50-54

BACKGROUND

Endoscopic ultrasonography (EUS) and endoscopic ultrasonography with fine needle aspiration (EUS-FNA) are among the methods of the diagnosis and differential diagnosis of neuroendocrine tumors of the pancreas (pNET).

OBJECTIVE

The purpose of our work is to analyze the results of EUS and EUS-FNA in the preoperative diagnosis of patients with pNET and to compare them with the data of modern literature.

MATERIAL AND METHODS

We retrospectively analyzed the results of EUS and EUS-FNA of morphologically confirmed pNET, which were performed in the period between February 2012 and December 2021. The study included 62 patients with localized forms and common neoplasms, including metastatic lesions of the lymph nodes and liver. We evaluated ultrasonographic and morphological characteristics of the detected neoplasms, including informative morphological conclusion.

RESULTS

We have analyzed performance of pNET diagnostics with the examples of EUS and EUS-FNA results in 62 patients. The EUS characteristics of the pNET were analyzed, as well as the results of the EUS-FNA. The average size of the neoplasms was 24±4.13 mm. The most frequent localization of pNET was the head of the pancreas — 21 cases (33.9%), then the body of the pancreas — 19 cases (30.6%), in 8 cases (12.9%) the lesions were localized in the tail of the pancreas, 2 cases (3.2%) manifested themselves on the wall of the duodenum. Multiple lesions occurred in 12 cases (19.3%). In 8% of cases, pNET had an atypical EUS picture, in 3 cases (5%) we detected a cystic form of neoplasia. The technical success of EUS-FNA was 100%. In 86.7%, the results of EUS-FNA were explicit, in 13.3% — doubtful. There were no vague EUS-FNA results. At the same time, in 57 cases (95%), IHC was performed, including the calculation of the index of proliferative activity Ki67. According to the Grade classification, the cases were distributed as follows: Grade 1 — 19 cases (34.9%), Grade 2 — 29 cases (53.3%), Grade 3 — 1 case (1.8%), neuroendocrine carcinoma — 10.1%.

CONCLUSION

EUS and EUS-FNA are effective methods of diagnosis, staging and morphological detection of pNET. This method should be included in the selection of diagnostic methods of pNET, especially in cases of surgical treatment.

Keywords:

EUS
EUS-FNA
pancreas
neuroendocrine tumors
neuroendocrine tumors of the pancreas
pNET

Authors:

E.G. Solonitsyn

Almazov National Medical Research Center

A.V. Poddymova

Almazov National Medical Research Centre

V.F. Kamalova

Almazov National Medical Research Centre

T.M. Shestopalova

Almazov National Medical Research Centre

L.B. Mitrofanova

Almazov National Medical Research Centre

S.Sh. Seyfedinova

Almazov National Medical Research Centre

A.A. Shpomer

Almazov National Medical Research Centre

Received:

25.09.2022

Accepted:

09.03.2023

List of references:

  1. Howe J, Merchant N, Conrad C, Keutgen XM, Hallet J, Drebin JA, Minter RM, Lairmore TC, Tseng JF, Zeh HJ, Libutti SK, Singh G, Lee JE, Hope TA, Kim MK, Menda Y, Halfdanarson TR, Chan JA, Pommier RF. The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors. Pancreas. 2020;49(1):1-33.  https://doi.org/10.1097/MPA.0000000000001454
  2. Milan SA, Yeo CJ. Neuroendocrine tumors of the pancreas. Curr Opin Oncol. 2012;24(1):46-55.  https://doi.org/10.1097/CCO.0b013e32834c554d
  3. Baur AD, Pavel M, Prasad V, Denecke T. Diagnostic imaging of pancreatic neuroendocrine neoplasms (pNEN): tumor detection, staging, prognosis, and response to treatment. Acta Radiol. 2016;57(3):260-270.  https://doi.org/10.1177/0284185115579932
  4. Dickson PV, Behrman SW. Management of pancreatic neuroendocrine tumors. Surg Clin North Am. 2013;93(3):675-691.  https://doi.org/10.1016/j.suc.2013.02.001
  5. Scott AT, Howe JR. Evaluation and Management of Neuroendocrine Tumors of the Pancreas. Surg Clin North Am. 2019;99(4):793-814.  https://doi.org/10.1016/j.suc.2019.04.014
  6. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB. One hundred years after «carcinoid»: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26(18):3063-3072. https://doi.org/10.1200/JCO.2007.15.4377
  7. Patel KK, Kim MK. Neuroendocrine tumors of the pancreas: endoscopic diagnosis. Curr Opin Gastroenterol. 2008;24(5):638-642.  https://doi.org/10.1097/MOG.0b013e32830bf7fb
  8. James PD, Tsolakis AV, Zhang M, Belletrutti PJ, Mohamed R, Roberts DJ, Heitman SJ. Incremental benefit of preoperative EUS for the detection of pancreatic neuroendocrine tumors: a meta-analysis. Gastrointest Endosc. 2015;81(4):848-56.e1.  https://doi.org/10.1016/j.gie.2014.12.031
  9. Dietrich CF, Sahai AV, D’Onofrio M, Will U, Arcidiacono PG, Petrone MC, Hocke M, Braden B, Burmester E, Möller K, Săftoiu A, Ignee A, Cui XW, Iordache S, Potthoff A, Iglesias-Garcia J, Fusaroli P, Dong Y, Jenssen C. Differential diagnosis of small solid pancreatic lesions. Gastrointest Endosc. 2016;84(6):933-940.  https://doi.org/10.1016/j.gie.2016.04.034
  10. Braden B, Jenssen C, D’Onofrio M, Hocke, M, Will U, Möller K, Ignee A, Dong Y, Cui XW, Sãftoiu A, Dietrich CF. B-mode and contrast-enhancement characteristics of small nonincidental neuroendocrine pancreatic tumors. Endosc Ultrasound. 2017;6(1):49-54.  https://doi.org/10.4103/2303-9027.200213
  11. Krishna SG, Rao BB, Ugbarugba E, Shah ZK, Blaszczak A, Hinton A, Conwell DL, Hart PA. Diagnostic performance of endoscopic ultrasound for detection of pancreatic malignancy following an indeterminate multidetector CT scan: a systemic review and meta-analysis. Surg Endosc. 2017;31(11):4558-4567. https://doi.org/10.1007/s00464-017-5516-y
  12. Cotton PB, Eisen GM, Aabakken L, Baron TH, Hutter MM, Jacobson BC, Mergener K, Nemcek A Jr, Petersen BT, Petrini JL, Pike IM, Rabeneck L, Romagnuolo J, Vargo JJ. A lexicon for endoscopic adverse events: report of an ASGE workshop. Gastrointest Endosc. 2010;71(3):446-454.  https://doi.org/10.1016/j.gie.2009.10.027
  13. Mitra V, Nayar MK, Leeds JS, Wadehra V, Haugk B, Scott J, Charnley RM, Oppong KW. Diagnostic performance of endoscopic ultrasound (EUS)/endoscopic ultrasound — fine needle aspiration (EUS-FNA) cytology in solid and cystic pancreatic neuroendocrine tumours. J Gastrointestin Liver Dis. 2015;24(1):69-75.  https://doi.org/10.15403/jgld.2014.1121.vmi
  14. Manta R, Nardi E, Pagano N, Ricci C, Sica M, Castellani D, Bertani H, Piccoli M, Mullineris B, Tringali A, Marini F, Germani U, Villanacci V, Casadei R, Mutignani M, Conigliaro R, Bassotti G, Zullo A. Pre-operative Diagnosis of Pancreatic Neuroendocrine Tumors with Endoscopic Ultrasonography and Computed Tomography in a Large Series. J Gastrointestin Liver Dis. 2016;25(3):317-321.  https://doi.org/10.15403/jgld.2014.1121.253.ned
  15. Fujimori N, Osoegawa T, Lee L, Tachibana Y, Aso A, Kubo H, Kawabe K, Igarashi H, Nakamura K, Oda Y, Ito T. Efficacy of endoscopic ultrasonography and endoscopic ultrasonography-guided fine-needle aspiration for the diagnosis and grading of pancreatic neuroendocrine tumors. Scand J Gastroenterol. 2016;51(2):245-252.  https://doi.org/10.3109/00365521.2015.1083050
  16. Wcislak SM, Stiles ZE, Deneve JL, Glazer ES, Behrman SW, Farooq FT, Dickson PV. Hypervascular lesions of the pancreas: Think before you act. Am J Surg. 2019;218(2):362-367.  https://doi.org/10.1016/j.amjsurg.2018.11.021
  17. Ridtitid W, Halawi H, DeWitt JM, Sherman S, LeBlanc J, McHenry L, Coté GA, Al-Haddad MA. Cystic pancreatic neuroendocrine tumors: outcomes of preoperative endosonography-guided fine needle aspiration, and recurrence during long-term follow-up. Endoscopy. 2015;47(7):617-625.  https://doi.org/10.1055/s-0034-1391712
  18. Yasumoto M, Okabe Y, Sugiyama G, Naito Y, Nakayama M, Hisaka T, Ishikawa H, Horiuchi H, Kunou Y, Ushijima T, Ishida Y, Tsuruta O, Torimura T. A case of pancreatic neuroendocrine tumor with multiple cystic components of various sizes. Clin J Gastroenterol. 2018;11(1):87-91.  https://doi.org/10.1007/s12328-017-0798-0
  19. de Herder WW, Niederle B, Scoazec JY, Pauwels S, Kloppel G, Falconi M, Kwekkeboom DJ, Oberg K, Eriksson B, Wiedenmann B, Rindi G, O’Toole D, Ferone D. Well-differentiated pancreatic tumor/carcinoma: insulinoma. Neuroendocrinology. 2006;84(3):183-188.  https://doi.org/10.1159/000098010
  20. Sugimoto M, Takagi T, Hikichi T, Suzuki R, Watanabe K, Nakamura J, Kikuchi H, Konno N, Waragai Y, Asama H, Takasumi M, Watanabe H, Obara K, Ohira H. Efficacy of endoscopic ultrasonography-guided fine needle aspiration for pancreatic neuroendocrine tumor grading. World J Gastroenterol. 2015;21(26):8118-8124. https://doi.org/10.3748/wjg.v21.i26.8118
  21. Unno J, Kanno A, Masamune A, Kasajima A, Fujishima F, Ishida K, Hamada S, Kume K, Kikuta K, Hirota M, Motoi F, Unno M, Shimosegawa T. The usefulness of endoscopic ultrasound-guided fine-needle aspiration for the diagnosis of pancreatic neuroendocrine tumors based on the World Health Organization classification. Scand J Gastroenterol. 2014;49(11):1367-1374. https://doi.org/10.3109/00365521.2014.934909
  22. Weynand B, Borbath I, Bernard V, Sempoux C, Gigot JF, Hubert C, Lannoy V, Deprez PH, Jouret-Mourin A. Pancreatic neuroendocrine tumour grading on endoscopic ultrasound-guided fine needle aspiration: high reproducibility and inter-observer agreement of the Ki-67 labelling index. Cytopathology. 2014;25(6):389-395.  https://doi.org/10.1111/cyt.12111
  23. Boutsen L, Jouret-Mourin A, Borbath I, van Maanen A, Weynand B. Accuracy of Pancreatic Neuroendocrine Tumour Grading by Endoscopic Ultrasound-Guided Fine Needle Aspiration: Analysis of a Large Cohort and Perspectives for Improvement. Neuroendocrinology. 2018;106(2):158-166.  https://doi.org/10.1159/000477213
  24. Hasegawa T, Yamao K, Hijioka S, Bhatia V, Mizuno N, Hara K, Imaoka H, Niwa Y, Tajika M, Kondo S, Tanaka T, Shimizu Y, Kinoshita T, Kohsaki T, Nishimori I, Iwasaki S, Saibara T, Hosoda W, Yatabe Y. Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors. Endoscopy. 2014;46(1):32-38.  https://doi.org/10.1055/s-0033-1344958
  25. Di Leo M, Poliani L, Rahal D, Auriemma F, Anderloni A, Ridolfi C, Spaggiari P, Capretti G, Di Tommaso L, Preatoni P, Zerbi A, Carnaghi C, Lania A, Malesci A, Repici A, Carrara S. Pancreatic Neuroendocrine Tumours: The Role of Endoscopic Ultrasound Biopsy in Diagnosis and Grading Based on the WHO 2017 Classification. Dig Dis. 2019;37(4):325-333.  https://doi.org/10.1159/000499172
  26. Delektorskaya VV. Neuroendocrine tumors of the digestive system: pathologic and molecular characteristics. Uspekhi molekulyarnoi onkologii. 2015;2(1):052-060. (In Russ.). https://doi.org/10.17650/2313-805X.2015.2.1.052-060
  27. Iukina MI, Tiul’pakov AN, Troshina EA, Bel’tsevich DG. Von Hippel-Lindau disease (VHL-syndrome). Problemy Endocrinologii. 2012;58(2):34-41.  https://doi.org/10.14341/probl201258234-41
Contact the author
Email
Message

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
E-mail
Password
Forgot Password?

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.