
Surgical treatment of hemifacial spasm: a systematic review
Журнал: Вопросы нейрохирургии имени Н.Н. Бурденко. 2026;90(2):112-119.
DOI: 10.17116/neiro202690021112
Read: 2048 раз
Abstract
The annual incidence of hemifacial spasm is 8-15 cases per 100.000. This disease is not life-threatening, but it significantly impacts the quality of life. Primary treatment is vascular decompression of the facial nerve. Thus, improvement of appropriate technique is crucial for higher efficacy and safety.
OBJECTIVE
To determine the optimal algorithm for vascular decompression according to available international experience in surgical treatment of hemifacial spasm.
MATERIAL AND METHODS
A systematic review was conducted in accordance with the PRISMA guidelines. To identify relevant publications, we screened the PubMed, Google Scholar, and eLibrary databases through October 2024 using the keywords «microvascular decompression» and «hemifacial spasm». Only full-text articles in Russian, English, or French were included in the study.
RESULTS
Among 364 manuscripts, 24 met the inclusion criteria. The majority of studies demonstrated available experience and effectiveness of vascular decompression without description of surgical approach.
CONCLUSION
Considering global experience, we proposed an optimal surgical algorithm, including initial dissection of bulbar nerves and facial nerve decompression, if possible, along its entire length.
Keywords
- hemifacial spasm
- vascular decompression
- neurovascular conflict
- facial nerve
Дата поступления: 08.12.2025
Дата принятия в печать: 30.01.2026
Дата публикации: 03.04.2026
- Kemp LW, Reich SG. Hemifacial spasm. Current Treatment Options in Neurology. 2024;6(3):175-179. https://doi.org/10.1007/s11940-004-0009-4
- Shamalov NA, Zavaliy LB, Petrikov SS, Ramazanov GR, Tyrov IA, Koriagin AN, Fomkin AG, Kuular DV, Nikulina TA, Andriyanova EV. Epidemiologic characteristics of facial nerve diseases in a metropolis according to the unified medical city systems. Medicine and Health Care Organization. 2024;9(2):60-69. https://doi.org/10.56871/MHCO.2024.64.49.007
- Salari M, Alikhani A, Vakoli K, Fathi M, Etemadifar M. Primary hemifacial spasm: anatomical insights. Acta Neurologica Belgica. 2025;125(1):35-41. https://doi.org/10.1007/s13760-024-02660-4.
- Ahmed A, Alsulaiman N, Diab MM, Alsuhaibani AH. Periocular clinical differences between primary and postparalytic hemifacial spasm: A retrospective comparative study. Indian Journal of Ophthalmology. 2025;73(10):1438-1442. https://doi.org/10.4103/IJO.IJO_806_25
- Ghaffari-Rafi A, Choi SY, Leon-Rojas J, Shahlaie K. Predictors of Multi-Vessel Identification, Outcome, and Optimal Surgical Timing for Microvascular Decompression in Hemifacial Spasm. Clinical Neurology and Neurosurgery. 2023;233:107841. https://doi.org/10.1016/j.clineuro.2023.107841
- Chen YY, Chuang MT, Tai SH, Lee EJ. Choroid plexus papilloma at the root entry zone causing hemifacial spasm. The Kaohsiung Journal of Medical Sciences. 2023;39(11):1157-1158. https://doi.org/10.1002/kjm2.12747
- Ogul H, Unlu EN, Guclu D, Koksal A. Cerebellar Developmental Venous Anomaly Causing Tinnitus and Hemifacial Spasm: A Case Report. Ear, Nose, & Throat Journal. 2025;104(9):553-555. https://doi.org/10.1177/01455613221133226
- Graboyes AZ, Quimby AE, Heman-Ackah S, Stone SL, Brant JA, Bigelow DC, Lee JYK. Radiation-induced cavernous malformation within a vestibular schwannoma: A case report. SAGE Open Medical Case Report. 2025;13: 2050313X251390626. https://doi.org/10.1177/2050313X251390626
- Hashiguchi A, Takemoto Y, Ueda R, Moroki K, Tokuda H. Spontaneous Resolution of Hemifacial Spasm Following Falcotentorial Meningioma Resection: Impact of Posterior Cranial Fossa Volume Changes on Hemifacial Spasm. Cureus. 2025;17(6):e85450. https://doi.org/10.7759/cureus.85450
- Bonomo R, Bonomo G, Iess G, Schiariti MP, Falco J, Stanziano M, Restelli F, Mazzapicchi, Broggi M, Labiad I, Acerbi F, Barbagallo GMV, Ferroli P. Evaluating the diagnostic role of magnetic resonance imaging in trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia: A controlled blinded study. Brain & Spine. 2025;5:105607. https://doi.org/10.1016/j.bas.2025.105607
- Jannetta PJ. Microsurgical exploration and decompression of the facial nerve in hemifacial spasm. Current Topics in Surgical Research. 1970;2:217-222.
- Zachem TJ, Bello A, Lee B, Luo E, Woo J, Yoo S, Duerr E, Massat E, Hunter A, Yamamoto K, Adil SM, Kaplan S, Hachem RA, Husain AM, Codd PJ, Zomorodi A, Goodwin CR, Abdelgadir J. Current state of intraoperative neuromonitoring of the facial nerve during skull base surgery: A systematic review. Journal of Clinical Neuroscience. 2025;140:111525. https://doi.org/10.1016/j.jocn.2025.111525
- Pan SY, Lai CM, Huang CW, Chen YC, Yang LY, Guo L. Is complete elimination of lateral spreading response essential in microvascular decompression for hemifacial spasm? Neurosurgical Focus. 2025;59(3):E5. https://doi.org/10.3171/2025.6.FOCUS25436
- Yang J, Yang X, Liu H, Liu J, Li K, Shi J, Liang Y, Song Y, Fan X, Qiao H. The application value of intraoperative lateral spreading response monitoring during microvascular decompression in patients with primary hemifacial spasm. European Journal of Medical Research. 2025;30(1):1095. https://doi.org/10.1186/s40001-025-03293-w
- Ansari A, Tavanaei R, Alikhani A, Hajikarimloo B, Zoghi S, Alnemari AM, Khorasanizadeh M, Zwagerman NT. Fully endoscopic microvascular decompression for hemifacial spasm: a systematic review. Neurosurgical Review. 2025;48(1):285. https://doi.org/10.1007/s10143-025-03181-1
- Wang Q, Hao X, Liu Q, Chen J, Jiang R, Xu X, Shi W. Fully Endoscopic Microvascular Decompression for Hemifacial Spasm Using 2-Dimensional/3-Dimensional Endoscopy: Clinical Analysis of 204 Cases. Operative Neurosurgery. 2025. https://doi.org/10.1227/ons.0000000000001758
- Ghaffari-Rafi A, Choi SY, Leon-Rojas J, Shahlaie K. Predictors of Multi-Vessel Identification, Outcome, and Optimal Surgical Timing for Microvascular Decompression in Hemifacial Spasm. Clinical Neurology and Neurosurgery. 2023;233:107841. https://doi.org/10.1016/j.clineuro.2023.107841
- Jesuthasan A, Natalwala A, Davagnanam I, Saifee T, Zrinzo L. Hemifacial spasm: an update on pathophysiology, investigations and management. Journal of Neurology. 2025;272(8):502. https://doi.org/10.1007/s00415-025-13220-y
- De Melo DLM, Bento Oliveira DRDCA, Pinheiro DS, Manzano GM. Ephatic transmission impairs trigemino-cervical reflex monitoring during microvascular decompression surgery for hemifacial spasm. Clinical Neurophysiology. 2025;174:59-60. https://doi.org/10.1016/j.clinph.2025.03.039
- Nielsen VK. Electrophysiology of the facial nerve in hemifacial spasm: ectopic/ephaptic excitation. Muscle Nerve. 1985;8(7):545-555. https://doi.org/10.1002/mus.880080702
- Duan Y, Lv K, Zhao C, Han L, Wang J, Zhang C, Zhang Z, Liu H, Yang K, Yuan Z, Zhu L, Wang Y, Luan J, Ma G, Liu J. Exploring Facial Nucleus-Centered Connectivity in Hemifacial Spasm: Novel Insights into Pathogenesis and Surgical Impact. Brain Topography. 2025;38(5):58. https://doi.org/10.1007/s10548-025-01133-y
- Amano Y, Asayama B, Noro S, Abe T, Okuma M, Honjo K, Seo Y, Nakamura H. Correlation between Delayed Relief after Microvascular Decompression and Morphology of the Lateral Spread Response in Patients with Hemifacial Spasm-Temporal versus Mandibular Branch Stimulation. Neurologia Medico-chirurgica. 2024;65(2):45-51. https://doi.org/10.2176/jns-nmc.2024-0062
- Campos-Benitez M, Kaufmann AM. Neurovascular compression findings in hemifacial spasm. Journal of Neurosurgery. 2008;109(3):416-420. https://doi.org/10.3171/JNS/2008/109/9/0416
- Goto Y, Inoue T. A bony landmark in craniotomy for hemifacial spasm: The inferior retrosigmoid eminence. Neurosurgical Review. 2025;48(1):700. https://doi.org/10.1007/s10143-025-03865-8
- Grigoryan GYu, Dzhindzhikhadze RS, Shumovsky VK, Grigoryan YuA. Interposition and transposition techniques of vascular decompression for hemifacial spasm. Burdenko’s Journal of Neurosurgery. 2023;87(2):30-40. https://doi.org/10.17116/neiro20238702130
- Draghi R, Tengattini F, Travaglini F, Salomi F, Sangiorgi D, Borghesi I, Calbucci F. Muscle pad interposition technique in microvascular decompression for primary hemifacial spasm: a single-center case series and systematic review. Neurosurgical Focus. 2025;59(3):E7. https://doi.org/10.3171/2025.6.FOCUS25432
- Amagasaki K, Watanabe S, Naemura K, Shono N, Hosono A, Nakaguchi H. Transposition of the Culpit Artery Passing Between the Facial Nerve and Auditory Nerve in Microvascular Decompression Surgery for Hemifacial Spasm. World Neurosurgery. 2019;127:e996-e1002. https://doi.org/10.1016/j.wneu.2019.04.020
- Corvino S, Seneca V, Iaconetta G, Catapano G. How I do it: sling transposition technique with biopatch and aneurysm clip for hemifacial spasm. Acta Neurochirurgica. 2025;167(1):260. https://doi.org/10.1007/s00701-025-06634-0
- Pusat S, Erdogan E, Atar M, Erbas YC, Erdogan E. Microvascular Decompression for Hemifacial Spasm without the Use of Neuromonitoring and Fix Retraction: A Single-Center Experience. Turkish Neurosurgery. 2024;34(3):429-434. https://doi.org/10.5137/1019-5149.JTN.42249-22.3
- Nonaka Y, Hayashi N, Matsumae M, Fukushima T. Wedge-technique for transposition of the vertebral artery in microvascular decompression for hemifacial spasm: technical nuances and surgical outcomes. Acta Neurochirurgica. 2019;161:1435-1442. https://doi.org/10.1007/s00701-018-03793-1
- Park JS, Park K. Operative Findings of over 5000 Microvascular Decompression Surgeries for Hemifacial Spasm: Our Perspective and Current Updates. Life. 2023;13(9):1904. https://doi.org/10.3390/life13091904
- Zheng WJ, He R, Zhang X, Chen F, Chen L, Liu Y, Yang J, Deng Z, Jiang T, Huang G. Glue-transposition technique for hemifacial spasm involving vertebrobasilar dolichoectasia: a comparative study and literature review. Neurosurgical Review. 2025;48(1):495. https://doi.org/10.1007/s10143-025-03612-z
- Khan NR, Wu EM, Elarjani T, Morcos JJ. Macrovascular Decompression for Hemifacial Spasm Using Sling Technique. World Neurosurgery. 2023;170:67. https://doi.org/10.1016/j.wneu.2022.11.073
- Mori K, Otani N, Toyooka T, Morita S, Numazawa S, Wada K, Watanabe S. Validation of Efficacy and Safety of TachoSil® Tissue Sealant for Vessel Transposition in Microvascular Decompression. Operative Neurosurgery. 2023;25(5):417-425. https://doi.org/10.1227/ons.0000000000000844
- Kim JY, Jung S, Song TW, Kim IY, Moon KS, Jung TY, Jang WY. The Cornerstone Technique of Microvascular Decompression for Hemifacial Spasm with Vertebral Artery Offender. World Neurosurgery. 2019;126:e94-e100. https://doi.org/10.1016/j.wneu.2019.01.199
- Li Z, Gao J, Wang T, Li Y. Retrospective clinical analysis of 320 cases of microvascular decompression for hemifacial spasm. Medicine. 2018;97(41):e11825. https://doi.org/10.1097/MD.0000000000011825
- Inoue T, Shitara S, Goto Y, Arham A, Prasetya M, Radcliffe L, Fukushima T. Bridge technique for hemifacial spasm with vertebral artery involvement. Acta Neurochirurgica. 2021;163(12):3311-3320. https://doi.org/10.1007/s00701-021-05006-8
- Jiang X, Wu M, Fu X, Niu C, He F, Sun K, Zhuang H. Microvascular Decompression for Hemifacial Spasm Associated with Vertebral Artery: Biomedical Glue-Coated Teflon Sling Transposition Technique. World Neurosurgery. 2018;120:e342-e348. https://doi.org/10.1016/j.wneu.2018.08.073
- Li F, Liu R. Clinical analysis of microvascular decompression in patients with hemifacial spasm: a retrospective study. Annals of Palliative Medicine. 2020;9(2):318-323. https://doi.org/10.21037/apm.2020.01.11
- Lv MY, Deng SL, Long XF, Liu ZL. Long-term outcome of microvascular decompression for hemifacial spasm. British Journal of Neurosurgery. 2017;31(3):322-326. https://doi.org/10.1080/02688697.2017.1297368
- Amagasaki K, Watanabe S, Hosono A, Nakaguchi H. Mobilization of the Anterior/Posterior Inferior Cerebellar Artery on the Cerebellar Surface in Microvascular Decompression Surgery for Hemifacial Spasm: Potential Effect on Hearing Preservation. Operative Neurosurgery. 2019;16(2):179-185. https://doi.org/10.1093/ons/opy128
- Alkhayri A, Bourdillon P, Chauvet D, Bugdadi A, Alyousef M, Alsalmi S, Apra C, Lefaucheur JP, Aldea S, Le Guérinel C. Surgical treatment of hemifacial spasms: how to predict failure and complications through a series of 200 patients. Neurochirurgie. 2023;69(6):101498. https://doi.org/10.1016/j.neuchi.2023.101498
Recommended articles:
Vascular decompression in the treatment of vagoglossopharyngeal neuralgia.Burdenko's Journal of Neurosurgery. 2026;90(4):15-20
Hemifacial spasm in a child with Arnold—Chiari malformation type I.S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(5):134-137
Posterior petrous meningiomas: clinical manifestations, anatomical relationships and postoperative outcomes.Burdenko's Journal of Neurosurgery. 2026;90(1):29-38
Familial hemifacial spasm.S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(11-2):65-73
Origins of trigeminal neuralgia surgery (era of microvascular decompression).Burdenko's Journal of Neurosurgery. 2025;89(5):109-114
Origins of trigeminal neuralgia surgery (standing on the shoulders of giants).Burdenko's Journal of Neurosurgery. 2025;89(5):103-108
Topographic and anatomical features of cranial bones in patients with classical trigeminal neuralgia.Russian Journal of Pain. 2025;23(3):33-41
Analysis of classifications of the facial «danger zones».Russian Journal of Operative Surgery and Clinical Anatomy. 2025;9(2):57-62
