The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Turkin A.M.

Burdenko Neurosurgical Center

Melnikova-Pitskhelauri T.V.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Kravchuk A.D.

Burdenko Neurosurgical Center

Oshorov A.V.

Burdenko Neurosurgical Center

Lapina P.S.

Burdenko Neurosurgical Center

Petryaikin A.V.

Moscow Research Practical Clinical Center for Diagnostics and Telemedicine Technologies

Titov O.Yu.

Burdenko Neurosurgical Center

Ryzhova M.V.

Burdenko Neurosurgical Center;
Gemotest Medical Laboratory

Kozlov A.V.

Burdenko Neurosurgical Center;
Andijan State Medical Institute

Pronin I.N.

Burdenko Neurosurgical Center

Factors influencing peritumoral edema in meningiomas: CT- and MRI-based quantitative assessment

Authors:

Turkin A.M., Melnikova-Pitskhelauri T.V., Fadeeva L.M., Kravchuk A.D., Oshorov A.V., Lapina P.S., Petryaikin A.V., Titov O.Yu., Ryzhova M.V., Kozlov A.V., Pronin I.N.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2023;87(4): 17‑26

DOI: 10.17116/neiro20238704117

Read: 5454 times

Download PDF (RU)
Download PDF
Contact the author
Table of contents

FACTORS INFLUENCING PERITUMORAL EDEMA IN MENINGIOMAS: CT- AND MRI-BASED QUANTITATIVE ASSESSMENT
FACTORS INFLUENCING PERITUMORAL EDEMA IN MENINGIOMAS: CT- AND MRI-BASED QUANTITATIVE ASSESSMENT

To cite this article:

Turkin AM, Melnikova-Pitskhelauri TV, Fadeeva LM, et al. Factors influencing peritumoral edema in meningiomas: CT- and MRI-based quantitative assessment. Burdenko's Journal of Neurosurgery. 2023;87(4):17‑26. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20238704117

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Cere­brolysin with repe­rfusion therapy in ischemic stroke: a prospective analysis of multimodal brain imaging data from the CERE­HETIS trial. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):84-98
Cere­bral microangiopathy. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):15-24
Machine learning models for brain tumors differential diagnosis. Russian Journal of Preventive Medi­cine. 2025;(9):87-93
Gait diso­rders patients with patients with cere­bral microangiopathy: asso­ciation with the microstructural inte­grity of the tracts invo­lved in walking. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(11):123-131
Abstract:

Background. Meningiomas may be accompanied by peritumoral edema. Incidence and pathogenesis of edema are nor clearly established. Prevalence and severity of edema vary significantly in patients with meningiomas similar in various parameters.

OBJECTIVE

To assess peritumoral edema in intracranial meningiomas and factors influencing incidence and severity of this process.

MATERIAL AND METHODS

There were 126 patients (69% women) aged 19—76 years (median 53), who were diagnosed with 142 meningiomas. Patients underwent surgery (n=111) and radiotherapy (n=15) in 2016—2018. The MRI protocol included T1, T2, T2-FLAIR, DWI and post-contrast T1-weighted images in three projections, diffusion tensor MRI in 27 cases and MR spectroscopy in 21 patients.

RESULTS

Peritumoral edema was detected in 46% (n=66) of cases including 21 (31%) patients with severe edema. The ALPS index was 1.510±0.1931 in meningiomas without edema and 1.308±0.19 in those with edema (p=0.014). There was positive correlation between edema, dimensions and uneven contours of meningioma, as well as negative correlation with CSF cleft sign. Blood flow velocity was higher in atypical and anaplastic meningiomas with edema (p=0.03). Other signs (localization, histological variant, malignancy grade, characteristics of MR signal, peaks of the main metabolites, diffusion and perfusion parameters of tumor) did not significantly affect peritumoral edema in patients with meningiomas (p>0.05).

CONCLUSION

Diffusion tensor tomography with ALPS index revealed significant effect of glymphatic system dysfunction on peritumoral edema. Large meningioma with uneven contours increased the risk of peritumoral edema, while CSF cleft sign reduced this risk. Other factors did not affect cerebral edema in meningiomas.

Keywords:

meningiomas
peritumoral edema
CT perfusion
MR spectroscopy
diffusion tensor MRI
ALPS index

Authors:

Turkin A.M.

Burdenko Neurosurgical Center

Melnikova-Pitskhelauri T.V.

Burdenko Neurosurgical Center

Fadeeva L.M.

Burdenko Neurosurgical Center

Kravchuk A.D.

Burdenko Neurosurgical Center

Oshorov A.V.

Burdenko Neurosurgical Center

Lapina P.S.

Burdenko Neurosurgical Center

Petryaikin A.V.

Moscow Research Practical Clinical Center for Diagnostics and Telemedicine Technologies

Titov O.Yu.

Burdenko Neurosurgical Center

Ryzhova M.V.

Burdenko Neurosurgical Center;
Gemotest Medical Laboratory

Kozlov A.V.

Burdenko Neurosurgical Center;
Andijan State Medical Institute

Pronin I.N.

Burdenko Neurosurgical Center

Received:

20.04.2023

Accepted:

19.05.2023

Close metadata

References:

  1. Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, Barnholtz-Sloan JS. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015-2019. Neuro-Oncology. 2022;24(suppl 5):1-95.  https://doi.org/10.1093/neuonc/noac202
  2. Bečulić H, Skomorac R, Jusić A, Alić F, Mašović A, Burazerović E, Omerhodžić I, Dorić M, Imamović M, Mekić-Abazović A, Efendić A, Udovčić-Gagula D. Correlation of peritumoral brain edema with morphological characteristics and ki67 proliferative index in resected intracranial meningiomas. Acta Clinica Croatica. 2019;58(1):42-49.  https://doi.org/10.20471/acc.2019.58.01.06
  3. Berhouma M, Jacquesson T, Jouanneau E, Cotton F. Pathogenesis of peri-tumoral edema in intracranial meningiomas. Neurosurgical Review. 2019;42(1):59-71.  https://doi.org/10.1007/s10143-017-0897-x
  4. Nakano T, Asano K, Miura H, Itoh S, Suzuki S. Meningiomas with brain edema: radiological characteristics on MRI and review of the literature. Clinical Imaging. 2002;26(4):243-249.  https://doi.org/10.1016/s0899-7071(02)00433-3
  5. Sapkota MR, Yang Z, Zhu D, Zhang Y, Yuan T, Gao J, Si T, Wang J. Evaluation of Epidemiologic Factors, Radiographic Features, and Pathologic Findings for Predicting Peritumoral Brain Edema in Meningiomas. Journal of Magnetic Resonance Imaging. 2020;52(1):174-182.  https://doi.org/10.1002/jmri.27046
  6. Toh CH, Siow TY, Castillo M. Peritumoral Brain Edema in Meningiomas May Be Related to Glymphatic Dysfunction. Frontiers in Neuroscience. 2021;15:674898. https://doi.org/10.3389/fnins.2021.674898
  7. Toh CH, Castillo M. Peritumoral brain edema volume in meningioma correlates with tumor fractional anisotropy but not apparent diffusion coefficient or cerebral blood volume. Neuroradiology. 2021;63(8):1263-1270. https://doi.org/10.1007/s00234-021-02646-6
  8. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathologica. 2016;131(6):803-820.  https://doi.org/10.1007/s00401-016-1545-1
  9. Regelsberger J, Hagel C, Emami P, Ries T, Heese O, Westphal M. Secretory meningiomas: a benign subgroup causing life-threatening complications. Neuro-Oncology. 2009;11(6):819-824.  https://doi.org/10.1215/15228517-2008-109
  10. Taoka T, Masutani Y, Kawai H, Nakane T, Matsuoka K, Yasuno F, Kishimoto T, Naganawa S. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases. Japanese Journal of Radiology. 2017;35(4):172-178.  https://doi.org/10.1007/s11604-017-0617-z
  11. Maiuri F, Gangemi M, Cirillo S, Delehaye L, Gallicchio B, Carandente M, Giamundo A. Cerebral edema associated with meningiomas. Surgical Neurology. 1987;27(1):64-68.  https://doi.org/10.1016/0090-3019(87)90109-1
  12. Lee KJ, Joo WI, Rha HK, Park HK, Chough JK, Hong YK, Park CK. Peritumoral brain edema in meningiomas: correlations between magnetic resonance imaging, angiography, and pathology. Surgical Neurology. 2008;69(4):350-355; discussion 355.  https://doi.org/10.1016/j.surneu.2007.03.027
  13. Paek SH, Kim CY, Kim YY, Park IA, Kim MS, Kim DG, Jung HW. Correlation of clinical and biological parameters with peritumoral edema in meningioma. Journal of Neurooncology. 2002;60(3):235-245.  https://doi.org/10.1023/a:1021186401522
  14. Smith HP, Challa VR, Moody DM, Kelly DL Jr. Biological features of meningiomas that determine the production of cerebral edema. Neurosurgery. 1981;8(4):428-433.  https://doi.org/10.1227/00006123-198104000-00004
  15. Alguacil-Garcia A, Pettigrew NM, Sima AA. Secretory meningioma. A distinct subtype of meningioma. The American Journal of Surgical Pathology. 1986;10(2):102-111.  https://doi.org/10.1097/00000478-198602000-00003
  16. Bitzer M, Topka H, Morgalla M, Friese S, Wöckel L, Voigt K. Tumor-related venous obstruction and development of peritumoral brain edema in meningiomas. Neurosurgery. 1998;42(4):730-737.  https://doi.org/10.1097/00006123-199804000-00026
  17. Higgins JN, Burnet NG, Schwindack CF, Waters A. Severe brain edema caused by a meningioma obstructing cerebral venous outflow and treated with venous sinus stenting. Case report. Journal of Neurosurgery. 2008;108(2):372-376.  https://doi.org/10.3171/JNS/2008/108/2/0372
  18. Barresi V. Angiogenesis in meningiomas. Brain Tumor Pathology. 2011;28(2):99-106.  https://doi.org/10.1007/s10014-010-0012-2
  19. Otsuka S, Tamiya T, Ono Y, Michiue H, Kurozumi K, Daido S, Kambara H, Date I, Ohmoto T. The relationship between peritumoral brain edema and the expression of vascular endothelial growth factor and its receptors in intracranial meningiomas. Journal of Neurooncology. 2004;70(3):349-357.  https://doi.org/10.1007/s11060-004-9164-4
  20. Hou J, Kshettry VR, Selman WR, Bambakidis NC. Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor-directed therapy. Neurosurgical Focus. 2013;35(6):E2.  https://doi.org/10.3171/2013.8.FOCUS13301
  21. Shin C, Kim JM, Cheong JH, Ryu JI, Won YD, Ko Y, Han MH. Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas. PLoS One. 2021;16(6):e0252945. https://doi.org/10.1371/journal.pone.0252945
  22. Nakasu S, Nakajima M, Matsumura K, Nakasu Y, Handa J. Meningioma: proliferating potential and clinicoradiological features. Neurosurgery. 1995;37(6):1049-1055. https://doi.org/10.1227/00006123-199512000-00003
  23. Turkin AM, Dolgushin MB, Podoprigora AE, Takush SV, Pjashina DV, Fadeeva LM, Pronin IN, Kornienko VN. Evaluation of dynamic changes in peritumoral cerebral edema by diffusion-tensor magnetic resonance imaging and MR spectroscopy. Radiation diagnostics and therapy. 2012;3:51-57. (In Russ.).
  24. Romano A, Palizzi S, Romano A, Moltoni G, Di Napoli A, Maccioni F, Bozzao A. Diffusion Weighted Imaging in Neuro-Oncology: Diagnosis, Post-Treatment Changes, and Advanced Sequences-An Updated Review. Cancers. 2023;15(3):618.  https://doi.org/10.3390/cancers15030618
  25. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro-Oncology. 2021;23(8):1231-1251. https://doi.org/10.1093/neuonc/noab106
  26. Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science Translational Medicine. 2012;4(147):147ra111. https://doi.org/10.1126/scitranslmed.3003748
  27. Taoka T, Ito R, Nakamichi R, Kamagata K, Sakai M, Kawai H, Nakane T, Abe T, Ichikawa K, Kikuta J, Aoki S, Naganawa S. Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function: CHanges in Alps index on Multiple conditiON acquIsition eXperiment (CHAMONIX) study. Japanese Journal of Radiology. 2022;40(2):147-158.  https://doi.org/10.1007/s11604-021-01187-5
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.