The role of glial cell line-derived neurotrophic factor isoforms in human glial tumors

Revishchin A.V.; Parshina V.V.; Pavlova G.V.

doi:https://doi.org/10.17116/neiro202286061106

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Abstract:

Glial cell line-derived neurotrophic factor (GDNF) has a wide range of actions and positively affects viability, proliferative activity and migratory ability of cells in nervous system. That is why GDNF is being considered as a therapeutic molecule in the treatment of neurodegenerative diseases, in particular Parkinson’s disease. However, GDNF has the same effect on high-grade glioma cells promoting their growth, resistance to therapy and dissemination. Expression of this factor in tissues and cultures of gliomas is up to five times higher than in intact brain matter. It was revealed that epigenetic modifications in GDNF gene promoter contribute to overexpression. Target suppression of GDNF gene transcription slows down growth of glioma and decreases cell migration. This review is devoted to the effect of GDNF on glioma cells, causes and consequences of its overexpression. Further analysis of expression and function of various GDNF isoforms in glial tumors may be valuable to develop new treatment methods for these dangerous diseases.

Keywords:

glioma

GDNF

isoforms

expression

Authors:

Revishchin A.V.

Institute of Higher Nervous Activity and Neurophysiology

SPIN RSCI: 8515-7172
Scopus AuthorID: 7003954339
ORCID: 0000-0002-6007-6440

Parshina V.V.

Institute of Higher Nervous Activity and Neurophysiology;
Burdenko Neurosurgical Center

ORCID: 0000-0003-1885-9422

Pavlova G.V.

Sechenov First Moscow State Medical University;
Institute of Higher Nervous Activity and Neurophysiology;
Burdenko Neurosurgical Center

SPIN RSCI: 4633-8339
Scopus AuthorID: 7005650683
ORCID: 0000-0002-6885-6601

Received:

09.03.2022

Accepted:

11.10.2022

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References:

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