New opportunities for therapy of adjustment disorder in combat participants: results of a study on the domestic drug Aviandr

Esipov A.V.; Samushiya M.A.; Ivolgin A.F.; Khommyatov M.R.; Kozachuk A.Yu.; Elina I.A.; Eremitsky I.V.; Kochereva E.D.; Koveshnikov M.A.

doi:https://doi.org/10.17116/jnevro202512503162

Esipov A.V.

National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital

ORCID: 0000-0001-9443-7286

Samushiya M.A.

Central State Medical Academy of Department of Presidential Affairs

ORCID: 0000-0003-3681-9977

Ivolgin A.F.

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

ORCID: 0000-0002-8849-680X

Khommyatov M.R.

Central State Medical Academy

ORCID: 0000-0003-3105-0812

Kozachuk A.Yu.

National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital;
Central State Medical Academy of the Administrative Department of the President of the Russian Federation

ORCID: 0009-0007-2436-2849

Elina I.A.

National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital

ORCID: 0009-0004-1903-729X

Eremitsky I.V.

National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital

ORCID: 0009-0000-4891-5363

Kochereva E.D.

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

ORCID: 0009-0000-7952-9369

Koveshnikov M.A.

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

ORCID: 0009-0007-1068-7386

New opportunities for therapy of adjustment disorder in combat participants: results of a study on the domestic drug Aviandr

Authors:

Esipov A.V., Samushiya M.A., Ivolgin A.F., Khommyatov M.R., Kozachuk A.Yu., Elina I.A., Eremitsky I.V., Kochereva E.D., Koveshnikov M.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3): 62‑69

DOI: 10.17116/jnevro202512503162

Read: 738 times

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To cite this article:

Esipov AV, Samushiya MA, Ivolgin AF, et al. . New opportunities for therapy of adjustment disorder in combat participants: results of a study on the domestic drug Aviandr. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(3):62‑69. (In Russ.)
https://doi.org/10.17116/jnevro202512503162

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

OBJECTIVE

To examine the clinical-psychopathological structure of adjustment disorders among sanitary losses of military personnel receiving medical care in a multidisciplinary military hospital, assessing the effectiveness of therapy for adjustment disorder symptoms with the drug Aviandr.

MATERIAL AND METHODS

A single-center experimental uncontrolled study was conducted, involving 60 patients diagnosed with F43.2 — adjustment disorder; all patients were combat participants.

RESULTS

The structure of adjustment disorders in the military personnel group was characterized by the predominance of an anxiety symptom complex; significant contributions to the disorder’s structure also included depressive symptoms, dysphoria, and individual PTSD symptoms. Patients with spinal injuries and limb amputations experienced persistent pain syndrome resembling neuropathic and phantom pain. All patients received therapy with Aviandr at a dose of 10 mg twice daily for the first week, followed by an increase to 20 mg twice daily for the next three weeks. A statistically significant reduction in anxiety (p≤0.05) and post-traumatic stress symptoms was observed on the DTS, HARS, GAD-7, Likert scales scores and subjective assessments of state dynamics. In the group of patients with pain syndrome, the reduction in VAS scores was statistically significant but clinically insignificant.

CONCLUSION

The drug Aviandr demonstrated a significant clinical effect in this patient group with a high safety and tolerability profile, making it a potential option for the rapid and effective stabilization of the mental state of military personnel with acute stress-associated disorders.

Keywords:

adjustment disorder

combatants

Aviandr

Authors:

Esipov A.V.

National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital

ORCID: 0000-0001-9443-7286

Samushiya M.A.

Central State Medical Academy of Department of Presidential Affairs

ORCID: 0000-0003-3681-9977

Ivolgin A.F.

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

ORCID: 0000-0002-8849-680X

Khommyatov M.R.

Central State Medical Academy

ORCID: 0000-0003-3105-0812

Kozachuk A.Yu.

ORCID: 0009-0007-2436-2849

Elina I.A.

National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital

ORCID: 0009-0004-1903-729X

Eremitsky I.V.

National Medical Research Center for High Medical Technologies — A.A. Vishnevsky Central Military Clinical Hospital

ORCID: 0009-0000-4891-5363

Kochereva E.D.

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

ORCID: 0009-0000-7952-9369

Koveshnikov M.A.

Central State Medical Academy of the Administrative Department of the President of the Russian Federation

ORCID: 0009-0007-1068-7386

Received:

06.03.2025

Accepted:

15.03.2025

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