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Abzalova D.I.

Sklifosovsky Research Institute for Emergency Care

Sinkin M.V.

Sklifosovsky Research Institute for Emergency Care

Yakovlev A.A.

Scientific and Practical Psychoneurological Center

Prirodov A.V.

Sklifosovsky Research Institute for Emergency Care

Guekht A.B.

Scientific and Practical Psychoneurological Center;
Pirogov Russian National Research Medical University

Risk factors for de novo generalized tonic-clonic seizures in patients with supratentorial meningiomas after neurosurgical treatment

Authors:

Abzalova D.I., Sinkin M.V., Yakovlev A.A., Prirodov A.V., Guekht A.B.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(10): 69‑74

DOI: 10.17116/jnevro202312310169

Read: 3580 times

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Table of contents

RISK FACTORS FOR DE NOVO GENERALIZED TONIC-CLONIC SEIZURES IN PATIENTS WITH SUPRATENTORIAL MENINGIOMAS AFTER NEUROSURGICAL TREATMENT
RISK FACTORS FOR DE NOVO GENERALIZED TONIC-CLONIC SEIZURES IN PATIENTS WITH SUPRATENTORIAL MENINGIOMAS AFTER NEUROSURGICAL TREATMENT

To cite this article:

Abzalova DI, Sinkin MV, Yakovlev AA, Prirodov AV, Guekht AB. Risk factors for de novo generalized tonic-clonic seizures in patients with supratentorial meningiomas after neurosurgical treatment. S.S. Korsakov Journal of Neurology and Psychiatry. 2023;123(10):69‑74. (In Russ.)
https://doi.org/10.17116/jnevro202312310169

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To identify risk factors for de novo epileptic seizures in the early postoperative period in patients with supratentorial meningiomas.

MATERIAL AND METHODS

A retrospective case—control study was conducted in a ratio of 3 to 1. The case histories of all patients with supratentorial meningiomas that met the inclusion and exclusion criteria, who underwent surgical removal of the neoplasm in 01.01.17 to 12.31.20, were studied in the neurosurgical department of the Research Institute of Emergency Medicine named after N.V. Sklifosovsky. Of 133 patients without epileptic seizures and a history of taking antiepileptic drugs before surgery, 10% (n=14) had a de novo generalized tonic-clonic seizure in the early postoperative period. Among the remaining 119 patients, 42 patients were selected to form the control group, similar in age, localization and volume of the tumor with patients in the main group. In all patients, the clinical condition, the results of preoperative and postoperative neuroimaging with contrast enhancement, the course of the intraoperative period, as well as the duration and outcomes of hospitalization were assessed.

RESULTS

The risk factors for the development of de novo seizures were an increase in the volume of cerebral edema compared with the preoperative one according to postoperative CT data and the development of hemorrhagic transformation of cerebral edema.

CONCLUSION

A prospective study is needed to determine risk factors for de novo seizures and determine prophylactic treatment.

Keywords:

de novo seizures
postoperative seizures
early seizures
de novo risk factors

Authors:

Abzalova D.I.

Sklifosovsky Research Institute for Emergency Care

Sinkin M.V.

Sklifosovsky Research Institute for Emergency Care

Yakovlev A.A.

Scientific and Practical Psychoneurological Center

Prirodov A.V.

Sklifosovsky Research Institute for Emergency Care

Guekht A.B.

Scientific and Practical Psychoneurological Center;
Pirogov Russian National Research Medical University

Received:

20.03.2023

Accepted:

19.07.2023

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References:

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