Changes in the psychoemotional state under the influence of derivatives of neuroactive amino acids of rats after chronic alcohol intoxication

Borodkina L.E.; Smolnyakova Yu.A.; Muzyko E.A.; Tyurenkov I.N.

doi:https://doi.org/10.17116/jnevro2022122041112

Borodkina L.E.

Volgograd State Medical University

Smolnyakova Yu.A.

Volgograd State Medical University

Muzyko E.A.

Volgograd State Medical University

Tyurenkov I.N.

Volgograd State Medical University

Changes in the psychoemotional state under the influence of derivatives of neuroactive amino acids of rats after chronic alcohol intoxication

Authors:

Borodkina L.E., Smolnyakova Yu.A., Muzyko E.A., Tyurenkov I.N.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4): 112‑116

DOI: 10.17116/jnevro2022122041112

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To cite this article:

Borodkina LE, Smolnyakova YuA, Muzyko EA, Tyurenkov IN. Changes in the psychoemotional state under the influence of derivatives of neuroactive amino acids of rats after chronic alcohol intoxication. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4):112‑116. (In Russ.)
https://doi.org/10.17116/jnevro2022122041112

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To study an effect of neuroactive amino acids derivatives glufimet and mefargin on the psychoemotional state of rats after chronic alcohol intoxication (CAI).

MATERIAL AND METHODS

The study was carried out on 10-month-old female Wistar rats. CAI was modeled by replacing drinking water with a 10% solution of ethyl alcohol sweetened with sucrose (50 g/l) for 6 months. Animals (age — 16 months) were divided into groups at the end of alcoholization: 1 (n=15) — intact group — rats without CAI; 2 (n=14) — control — females after CAI; 3 (n=11), 4 (n=14), 5 (n=11) and 6 (n=10) — experimental — females after CAI who received the GABA derivative mefargin (25 mg/kg), the glutamic acid derivative glufimet (29 mg/kg) and comparison drugs phenotropil (25 mg/kg) and heptral (100 mg/kg), respectively. Substances were administered to rats after 6 months of alcoholization intraperitoneally once a day for 14 days, the intact and control groups received physiological saline. The psychoemotional state of the animals was studied in the «Open field» test, «Elevated plus maze» test, «Marble burying» test and the Porsolt swim test after the treatment.

RESULTS

In animals of the control group, an increase in anxiety was noted, as evidenced by a greater number of boluses in the Open Field test (3.43±0.56 vs. 1.47±0.39) compared to the intact group (p<0.05), short duration of stay in open arms (26.07±3.47 vs. 68.67±10.08) and fewer hangings from them (3.07±0.25 vs. 6.67±0.79) in the «Elevated plus maze» test. Rats after CAI buried more balls (8.79±1.15 versus 2.73±0.71, p<0.05), which indicated that they had compulsive behavior. In addition, females of the control group were observed to be depressed, as evidenced by a long period of immobilization in the Porsolt swim test (2.36±0.41 versus 0.87±0.31, p<0.05).

CONCLUSION

Mefargin, glufimet, phenotropil and heptral restricted anxiety and manifestations of obsessive-compulsive disorder in females subjected to alcoholism (p<0.05). The antidepressant effect was observed in animals treated with phenotropil and heptral after CAI (p<0.05).

Keywords:

chronic alcohol intoxication

derivatives of neuroactive amino acids

mefargin

glufimet

psychoemotional state

Authors:

Borodkina L.E.

Volgograd State Medical University

Smolnyakova Yu.A.

Volgograd State Medical University

Muzyko E.A.

Volgograd State Medical University

Tyurenkov I.N.

Volgograd State Medical University

Received:

17.09.2021

Accepted:

11.01.2022

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References:

McHugh RK, Weiss RD. Alcohol Use Disorder and Depressive Disorders. Alcohol Research: Current Reviews. 2019;40(1):arcr.v40.1.01. https://doi.org/10.35946/arcr.v40.1.01
Flook EA, Luchsinger JR, Silveri MM, Winder DG, Benningfield MM, Blackford JU. Anxiety during abstinence from alcohol: A systematic review of rodent and human evidence for the anterior insula’s role in the abstinence network. Addiction Biology. 2021;26(2):e12861. https://doi.org/10.1111/adb.12861
Petit G, Luminet O, Cordovil de Sousa Uva M, Monhonval P, Leclercq S, Spilliaert Q, Zammit F, Maurage P, de Timary P. Gender Differences in Affects and Craving in Alcohol-Dependence: A Study During Alcohol Detoxification. Alcoholism, Clinical and Experimental Research. 2017;41(2):421-431. https://doi.org/10.1111/acer.13292
Gallagher C, Radmall Z, O’Gara C, Burke T. Anxiety and depression among patients with alcohol dependence: co-morbid or substance-related problems? Irish Journal of Psychological Medicine. 2018;35(2):121-126. https://doi.org/10.1017/ipm.2017.25
Vengeliene V, Celerier E, Chaskiel L, Penzo F, Spanagel R. Compulsive alcohol drinking in rodents. Addiction Biology. 2009;14(4):384-396. https://doi.org/10.1111/j.1369-1600.2009.00177.x
Tyurenkov IN, Popova TA, Perfilova VN, Prokofiev II, Borisov AV, Kustova MV, Zaypullaev GI, Ostrovskij OV. Protective effects of a new glutamic acid derivative against stress after nNOS blockade. Biomedicinskaya Himiya. 2017;63(1):47-55. (In Russ.). https://doi.org/10.18097/PBMC20176301047
Bagmetova VV, Tyurenkov IN, Borodkina LE, Berestovitskaya VM, Vasilyeva OS. Neuroprotective effects of methyl ether of fenibut and its derivatives under correction of psychoneurological malfunctions caused by convulsive pathology. Fundamental’nye Issledovaniya. 2013;3-1:22-26. (In Russ.).
Burchinsky SG. Angioprotection: brain vessels’ protection in family medicine’s practice. Semejnaya Medicina. 2017;5:57-60. (In Russ.).
Kryzhanovskii SA, Tsorin IB, Kolik LG, Stolyaruk VN, Vititnova MB, Ionova EO, Sorokina AV, Durnev AD, Seredenin SB. Translation model of alcoholic cardiomyopathy. Molekulyarnaya Medicina. 2015;3:40-47. (In Russ.).
Yuanyuan J, Junyan Z, Cuola D, Jingjing C, Yuhui S, Dan X, Wei D, Yongsheng Z. Memantine attenuated alcohol withdrawal-induced anxiety-like behaviors through down-regulating NR1-CaMKII-ERK signaling pathway. Neuroscience Letters. Supplement. 2018;686:133-139. https://doi.org/10.1016/j.neulet.2018.09.006
Walker BM, Drimmer DA, Walker JL, Liu T, Mathé AA, Ehlers CL. Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains. Alcohol. 2010;44(6):487-493. https://doi.org/10.1016/j.alcohol.2010.06.006
Xu H, Li H, Liu D, Wen W, Xu M, Frank JA, Chen J, Zhu H, Grahame NJ, Luo J. Chronic voluntary alcohol drinking causes anxiety-like behavior, thiamine deficiency, and brain damage of female crossed high alcohol preferring mice. Frontiers in Pharmacology. 2021;12:614396. https://doi.org/10.3389/fphar.2021.614396
Arzua T, Yan Y, Jiang C, Logan S, Allison RL, Wells C, Kumar SN, Schäfer R, Bai X. Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids. Translational Psychiatry. 2020;10(1):347. https://doi.org/10.1038/s41398-020-01029-4
Reddy VD, Padmavathi P, Kavitha G, Saradamma B, Varadacharyulu N. Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties. Molecular and Cellular Biochemistry. 2013;375(1-2):39-47. https://doi.org/10.1007/s11010-012-1526-1
Shang P, Lindberg D, Starski P, Peyton L, Hong SI, Choi S, Choi DS. Chronic alcohol exposure induces aberrant mitochondrial morphology and inhibits respiratory capacity in the medial prefrontal cortex of mice. Frontiers in Neuroscience. 2020;14:561173. https://doi.org/10.3389/fnins.2020.561173
Tapia-Rojas C, Mira RG, Torres AK, Jara C, Pérez MJ, Vergara EH, Cerpa W, Quintanilla RA. Alcohol consumption during adolescence: a link between mitochondrial damage and ethanol brain intoxication. Birth Defects Research. 2017;109(20):1623-1639. https://doi.org/10.1002/bdr2.1172
Cossenza M, Socodato R, Portugal CC, Domith IC, Gladulich LF, Encarnação TG, Calaza KC, Mendonça HR, Campello-Costa P, Paes-de-Carvalho R. Nitric oxide in the nervous system: biochemical, developmental, and neurobiological aspects. Vitamins and Hormones. 2014;96:79-125. https://doi.org/10.1016/B978-0-12-800254-4.00005-2
Potupchik TV, Veselova OF, Gatskikh IV. Pharmacotherapeutic aspects of nootropics use in people with alcohol dependence. Medicinskij Alfavit. 2019;2(19):37-41. (In Russ.). https://doi.org/10.33667/2078-5631-2019-2-19(394)-37-41
Belenichev IF, Kucher TV.The influence of thiol antioxidants on the state of nitrosating stress in brain of rats with chronic ethanol intoxication. Farmakologіya ta Lіkars’ka Toksikologіya. 2016;2:24-29. (In Russ.).