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Mikhailov A.Yu.

Berezina I.Yu.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

Sumsky L.I.

Sklifosovsky Research Institute of Emergency Medicine

Scheidegger Yu.M.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

Goretskaya T.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

Arzumanov Yu.L.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

The changes in electroencephalogram parameters in patients in the somatogenic phase of acute poisoning with opioid receptor agonists

Authors:

Mikhailov A.Yu., Berezina I.Yu., Sumsky L.I., Scheidegger Yu.M., Goretskaya T.A., Arzumanov Yu.L.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4): 100‑111

DOI: 10.17116/jnevro2022122041100

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Table of contents

THE CHANGES IN ELECTROENCEPHALOGRAM PARAMETERS IN PATIENTS IN THE SOMATOGENIC PHASE OF ACUTE POISONING WITH OPIOID RECEPTOR AGONISTS
THE CHANGES IN ELECTROENCEPHALOGRAM PARAMETERS IN PATIENTS IN THE SOMATOGENIC PHASE OF ACUTE POISONING WITH OPIOID RECEPTOR AGONISTS

To cite this article:

Mikhailov AYu, Berezina IYu, Sumsky LI, Scheidegger YuM, Goretskaya TA, Arzumanov YuL. The changes in electroencephalogram parameters in patients in the somatogenic phase of acute poisoning with opioid receptor agonists. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(4):100‑111. (In Russ.)
https://doi.org/10.17116/jnevro2022122041100

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the parameters of the electroencephalogram (EEG) using the methods of computer processing of EEG data for an approach to the analysis of possible neurophysiological mechanisms underlying the fluctuations detected in the EEG in patients in the somatogenic phase of acute poisoning with opioid receptor agonists.

MATERIAL AND METHODS

Thirty-one patients were examined in the somatogenic phase of acute poisoning with opioid receptor agonists with a wakefulness level 3 to 15 points on the Glasgow Coma Scale. The EEG was recorded in accordance with the recommendations of the International Federation of Clinical Neurophysiology. The indicators of electrical activity of the brain were analyzed; computer processing of EEG data, including spectral analysis, localization of equivalent dipole sources of pathological electrical activity of the brain localization of the maximum of the equivalent density of EEG oscillation currents in the neocortex, was performed

RESULTS

Delta-band oscillations dominated in the majority of patients (65%, 20 patients). EEG delta waves were localized mainly at the level of the thalamus; using the method of low-resolution electromagnetic tomography, the localization of the maximum of the equivalent current density of delta oscillations in the projection of the neocortex was noted. Possible neurophysiological mechanisms of «pathological» delta waves recorded in the EEG of these patients are discussed

CONCLUSIONS

The changes on the EEG in these patients arise as a result of a disturbance of the function of the generator mechanisms of both cortical and activating structures of the brain, while the recorded slow-wave, mainly delta activity, taking into account the recording time (somatogenic phase), may be due to the action of secondary alternating factors (hypoxia and cerebral edema).

Keywords:

opiates
opioids
delta waves
neurophysiological mechanisms of the brain
cortical deafferentation
encephalopathy
electroencephalogram

Authors:

Mikhailov A.Yu.

Berezina I.Yu.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

Sumsky L.I.

Sklifosovsky Research Institute of Emergency Medicine

Scheidegger Yu.M.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

Goretskaya T.A.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

Arzumanov Yu.L.

Serbsky Federal Medical Research Centre for Psychiatry and Narcology

Received:

30.09.2021

Accepted:

30.11.2021

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