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Kozlova A.B.

Burdenko Neurosurgical Center

Korsakova M.B.

Burdenko Neurosurgical Center

Pitskhelauri D.I.

Skolkovo Institute of Science and Technology

Kudieva E.S.

Burdenko Neurosurgical Center

Dombaanay B.S.

Burdenko Neurosurgical Center

Vlasov P.A.

Burdenko Neurosurgical Center

Kamenetskaya M.I.

Burdenko Neurosurgical Center

Neurophysiological aspects of multiple hippocampal transection in intractable temporal lobe epilepsy

Authors:

Kozlova A.B., Korsakova M.B., Pitskhelauri D.I., Kudieva E.S., Dombaanay B.S., Vlasov P.A., Kamenetskaya M.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1): 104‑111

DOI: 10.17116/jnevro2022122011104

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Table of contents

NEUROPHYSIOLOGICAL ASPECTS OF MULTIPLE HIPPOCAMPAL TRANSECTION IN INTRACTABLE TEMPORAL LOBE EPILEPSY
NEUROPHYSIOLOGICAL ASPECTS OF MULTIPLE HIPPOCAMPAL TRANSECTION IN INTRACTABLE TEMPORAL LOBE EPILEPSY

To cite this article:

Kozlova AB, Korsakova MB, Pitskhelauri DI, Kudieva ES, Dombaanay BS, Vlasov PA, Kamenetskaya MI. Neurophysiological aspects of multiple hippocampal transection in intractable temporal lobe epilepsy. S.S. Korsakov Journal of Neurology and Psychiatry. 2022;122(1):104‑111. (In Russ.)
https://doi.org/10.17116/jnevro2022122011104

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To search for correlations between intraoperative electrocorticographic data and seizure control after the multiple hippocampal transections (MHT) in patients with symptomatic pharmacoresistant medial temporal lobe epilepsy.

MATERIAL AND METHODS

Six patients underwent MHT nearby the hippocampus. The left dominant hemisphere was affected in all cases. Patients had normal memory function. Follow up was 18 to 24 months. Scalp electroencephalogram (EEG) and electrocorticography (ECoG) were intaoperatively recorded. Transections of the hippocampus were performed until ECoG epileptiform discharges stopped.

RESULTS

Seizure control was achieved in five patients. Synchronous epileptiform activity disappeared in the hippocampus in all patients after MHT. Complete disappearance of epileptiform activity in the hippocampus and basal cortex was demonstrated in 2 cases. The epileptiform activity remained in the basal cortex in 3 patients.

CONCLUSIONS

Using the method of hippocampal transections it was possible to achieve the disappearance of synchronous epileptic activity in the hippocampus in all patients. It is correlated with good outcome in 5 out of 6 cases. Preservation and even arising of spiking in the basal temporal cortex are not a risk factor for maintaining seizures after complete resection of the epileptogenic substrate in the temporal lobe and hippocampal transections. A decrease in the background epileptiform activity on the scalp EEG was observed in 4 of 5 cases after the resection of the pathological substrate, uncus and amygdala.

Keywords:

hippocampal transection
temporal lobe epilepsy
electrocorticography
epilepsy surgery
memory function

Authors:

Kozlova A.B.

Burdenko Neurosurgical Center

Korsakova M.B.

Burdenko Neurosurgical Center

Pitskhelauri D.I.

Skolkovo Institute of Science and Technology

Kudieva E.S.

Burdenko Neurosurgical Center

Dombaanay B.S.

Burdenko Neurosurgical Center

Vlasov P.A.

Burdenko Neurosurgical Center

Kamenetskaya M.I.

Burdenko Neurosurgical Center

Received:

29.03.2021

Accepted:

27.09.2021

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