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Zykov V.P.

Russian Medical Academy Continuing Professional Education

Tics and Tourette’s syndrome in children

Authors:

Zykov V.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5): 116‑124

DOI: 10.17116/jnevro2020120051116

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TICS AND TOURETTE’S SYNDROME IN CHILDREN
TICS AND TOURETTE’S SYNDROME IN CHILDREN

To cite this article:

Zykov VP. Tics and Tourette’s syndrome in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(5):116‑124. (In Russ.)
https://doi.org/10.17116/jnevro2020120051116

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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The article represents a review of modern literature on tics and Tourette’s syndrome in paediatric population and describes recent advances in neurogenetics, neuroanatomy and neurotransmitter heterogeneity of the disease pathogenesis. The analysis of the literature supports the plausibility of transformation of tics and Tourette’s syndrome from psychiatric disorders into neurological disorders (according to ICD-11) based on recent data on neurophysiology and functional neuroanatomy. Neuroanatomy of motor behaviour is described as the most complex self-regulating neural network of thalamo-cortical loop, basal ganglia in combination with the limbic system, insular and cingulate cortex with involvement of hippocampus, subthalamic region and cerebellum. The evaluation of pharmaceutical treatment options has been carried out, including a review of successful local experience in treating tics in paediatric patients with hopantenic acid, topiramate and neuropeptides of cortexin.

Keywords:

tic
Tourette’s syndrome
cortical-striatum-thalamo-cortical loop

Authors:

Zykov V.P.

Russian Medical Academy Continuing Professional Education

Received:

02.04.2020

Accepted:

03.04.2020

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