The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Putilina M.V.

Kafedra nevrologii fakulteta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Rudakov K.V.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO

The chemoreactomic analysis of the central mechanisms of action of non-steroidal anti-inflammatory drugs

Authors:

Gromova O.A., Torshin I.Iu., Putilina M.V., Stakhovskaya L.V., Rudakov K.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(1): 70‑77

DOI: 10.17116/jnevro202012001170

Read: 3144 times

Download PDF (RU)
Contact the author
Table of contents

THE CHEMOREACTOMIC ANALYSIS OF THE CENTRAL MECHANISMS OF ACTION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
THE CHEMOREACTOMIC ANALYSIS OF THE CENTRAL MECHANISMS OF ACTION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

To cite this article:

Gromova OA, Torshin IIu, Putilina MV, Stakhovskaya LV, Rudakov KV. The chemoreactomic analysis of the central mechanisms of action of non-steroidal anti-inflammatory drugs. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(1):70‑77. (In Russ.)
https://doi.org/10.17116/jnevro202012001170

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Comparative study of the effi­cacy and safety of combined therapy with lornoxicam (Xefokam Rapid) and a nucleotide complex Xefo­mielyn in patients with exacerbation of chro­nic nonspecific low back pain. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):89-97
An open-label obse­rvational study of the effi­cacy and tole­rability of rapi­dly dissolving forms of aceclofenac and nime­sulide for oral use in the treatment of patients with acute non-specific low back pain (ASTRA study). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(12):141-147
Combined use of Keto­profen solu­tion and Fary­ngazon anti­septic in dentistry. Stomatology. 2025;(6):74-79
Abstract:

Objective. To perform a chemoreactome modeling of the pharmacological central effects of 4 non-steroidal anti-inflammatory drugs (NSAIDs): dexketoprofen, ketoprofen, aceclofenac, lornoxicam. Material and methods. An analysis of the pharmacological spectrum of the central action of dexketoprofen, ketoprofen, aceclofenac and lornoxicam was based on the chemoinformatic approach, which compared drug-likeness properties with public and commercial software. Results. The effectiveness of NSAIDs is related to the inhibition of cannabinoid receptors CB-1, the vanilloid receptor TRPV1, NMDA and AMPA receptors and of the GABA reuptake transporter, with dexketoprofen being the most effective inhibitor. The safety of the central effects of NSAID is due to weak interactions of the NSAIDs studied with opioid, adrenergic, serotonin and dopamine receptors. Chemoreactome modeling made it possible to compare the particulars of the effects of the studied NSAIDs on experimental pain and cramps. Conclusions. Inhibition of CB-1, TRPV1, NMDA, AMPA, GABA transporter by the NSAID molecules corresponds to a decrease in the intensity of nociceptive signals. A weak intervention of the studied NSAIDs in opioid, adrenergic, serotonin and dopaminergic neurotransmission corresponds to a decrease in the central side-effects of NSAIDs and to a lessened antagonism of these NSAIDs towards exogenous and endogenous opioids.

Keywords:

dexketoprofen
ketoprofen
aceclofenac
lornoxicam
chemoinformatics

Authors:

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Putilina M.V.

Kafedra nevrologii fakulteta usovershenstvovaniia vracheĭ Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Rudakov K.V.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO

Close metadata

References:

  1. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990—2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743-800. https://doi.org/10.1016/S0140-6736(15)60692-4
  2. Jackson T, Thomas S, Stabile V, Han X, Shotwell M, McQueen K. Prevalence of chronic pain in low-income and middle-income countries: a systematic review and meta-analysis. Lancet. 2015;385(2):10. https://doi.org/10.1016/S0140-6736(15)60805-4
  3. Putilina MV. Strategy of therapy in patients with back pain. Clinical Pharmacology and Therapy. 2010;5:5863. (In Russ.)
  4. STAT forecast: Opioids could kill nearly 500,000 Americans in the next decade ByMAXBLAUJUNE 27, 2017. Obrashchenie k saitu 25.10.19. https://www.statnews.com/2017/06/27/opioid-deaths-forecast/
  5. Obrashchenie k saitu 25.10.19. https://www.cdc.gov/drugoverdose/epidemic/index.html
  6. Balashov AM, Shahbazyan IE. Central mechanisms of analgesic action of non-steroidal anti-inflammatory drugs. Nauchno-Prakticheskaja Revmatologija. 2005;2:47-53. (In Russ.)
  7. Torshin IYu, Gromova OA. Expert data analysis in molecular pharmacology. 2012;748. (In Russ.)
  8. Torshin IYu, Gromova OA, Fedotova LE, Gromov AN. Comparative chemoreactomic analysis of dexketoprofen, ketoprofen and diclofenac. Nevrologija, Nejropsihiatrija, Psihosomatika. 2018;10(1):47-54. https://doi.org/10.14412/2074-2711-2018-1-47-54
  9. Torshin IYu, Rudakov KV. On the Procedures of Generation of Numerical Features Over Partitions of Sets of Objects in the Problem of Predicting Numerical Target Variables. Pattern Recognition and Image Analysis. 2019;29:4:654-667. https://doi.org/10.1134/S1054661819040175
  10. Torshin IYu, Gromova OA, Stakhovskaya LV, Semenov VA. Chemoreactomic analysis of tolperisone, tizanidine and baclofen molecules: anticholinergic, antispasmodic and analgesic mechanisms of action. Nevrologija, Nejropsihiatrija, Psihosomatika. 2018;10(4):72-80. https://doi.org/10.14412/2074-2711-2018-4-72-80
  11. Torshin IYu, Gromova OA, Stakhovskaya LV, Semenov VA, Gromov AN. Differential chemorectomic analysis of synergistic combinations of tolperisone and non-steroidal anti-inflammatory drugs. Nevrologija, Nejropsihiatrija, Psihosomatika. 2019;11:2:78-85.
  12. Torshin IYu. Ed. Gromova O.A. Sensing the change from molecular genetics to personalized medicine. Nova Biomedical Books, NY, USA, 2009, In «Bioinformatics in the Post-Genomic Era» series.
  13. Torshin IYu, Rudakov KV. On the application of the combinatorial theory ofsolvability to the analysis of chemographs. Part 1: fundamentals of modern chemicalbonding theory and the concept of the chemograph. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2014;24(1):11-23.
  14. Torshin IYu, Rudakov KV. On the application of the combinatorial theory ofsolvability to the analysis of chemographs. Part 2. local completeness of invariants of chemographs in view of the combinatorial theory of solvability. Pattern Recognitionand Image Analysis (Advances in Mathematical Theory and Applications). 2014;24(2):196-208.
  15. Torshin IYu. The study of the solvability of the genome annotation problem on sets ofelementary motifs. Pattern Recognition and Image Analysis (Advances in MathematicalTheory and Applications). 2011;21(4):652-662.
  16. McCarson KE, Enna SJ. GABA pharmacology: the search for analgesics. Neurochem Res. 2014;39(10):1948-1963. PMID: 24532294/ https://doi.org/10.1007/s11064-014-1254-x
  17. Corchero J, Manzanares J, Fuentes JA. Cannabinoid/opioid crosstalk in the central nervous system. Crit Rev Neurobiol. 2004;16(1-2):159-172. PMID: 15581411.
  18. Wong CL, Wai MK, Roberts MB. The effect of aspirin and paracetamol on the increased naloxone potency induced by morphine pretreatment. Eur J Pharmacol. 1980;67:241-246.
  19. Nielsen JA, Sparber SB. Indomethacin facilitates acute tolerance to and dependence upon morphine as measured by changes in fixed-ratio behavior and rectal temperature in rats. Pharmacol Biochem Behav. 1985;22:921-931.
  20. Powell KJ, Quirion R, Jhamandas K. Inhibition of neurokinin-substance P receptor and prostanoid activity prevents and reverses Ihe development of morphine tolerance in vivo and the morphine-induced increase in CG RP expression in cultured dorsal root ganglion neurons. Eur J Neurosci. 2003;18:1572-1583.
  21. Berrocoso E, Sánchez-Blázquez P, Garzón J, Mico JA. Opiates as antidepressants. Curr Pharm Des. 2009;15(14):1612-1622.
  22. Fattori V, Hohmann MS, Rossaneis AC, Pinho-Ribeiro FA, Verri WA. Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules. 2016;21(7). pii: E844. PMID: 27367653. https://doi.org/10.3390/molecules21070844
  23. Gegelashvili G, Bjerrum OJ. Glutamate transport system as a key constituent of glutamosome: Molecular pathology and pharmacological modulation in chronic pain. Neuropharmacology. 2019. pii: S0028-3908(19)30144-3. https://doi.org/10.1016/j.neuropharm.2019.04.029
  24. Putilina MV, Teplova NV. Racionalnaya farmakoterapiya hronicheskoj ishemii golovnogo mozga. M.: Medpress inform 2019. https://doi.org/10.24421/MP.2019.39.37199
  25. Sotgiu ML, Biella G, Formaglio F, Marchettini P. Central effect of ketorolac involving NMDA receptors activity. Brain Res. 1998;813:223-226.
  26. Edwards SR, Mather LE, Lin Y, Power I, Cousins MJ Glutamate and kynarenate in the rat central nervous system following treatments with tail ischaemia or diclofenac. J Pharm Pharmacol. 2000;52(1):59-66.
  27. Imanishi T, Akahane K, Akaike N. Evidence that a hybrid molecule of norfloxacin and biphenylacetic acid is a potent antagonist at the GABAA receptor. Neuropharmacol. 1996;35:12711277.
  28. Akada S, Takeda S, Ogawa R. Salicylate action on medullary inspiratory neuron activity in a brainstem-spinal cord preparation from newborn rats. Anesth Analg. 2003;96:407-41i.
  29. Hayashida KI, Obata H. Strategies to Treat Chronic Pain and Strengthen Impaired Descending Noradrenergic Inhibitory System. Int J Mol Sci. 2019;20(4). pii: E822. PMID: 30769838. https://doi.org/10.3390/ijms20040822
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.