The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Verbitsky E.V.

Southern Scientific Center of the Russian Academy of Sciences

Arapova Yu.Yu.

Rostov State Medical University

The role of cerebral activation in the sleep—wake cycle

Authors:

Verbitsky E.V., Arapova Yu.Yu.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5‑2): 14‑19

DOI: 10.17116/jnevro202412405214

Read: 951 times

Download PDF (RU)
Contact the author
Table of contents

THE ROLE OF CEREBRAL ACTIVATION IN THE SLEEP—WAKE CYCLE
THE ROLE OF CEREBRAL ACTIVATION IN THE SLEEP—WAKE CYCLE

To cite this article:

Verbitsky EV, Arapova YuYu. The role of cerebral activation in the sleep—wake cycle. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(5‑2):14‑19. (In Russ.)
https://doi.org/10.17116/jnevro202412405214

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Energy processes in the sleep—wake cycle. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):8-13
The pote­ntial of neurofeedback control in treating inso­mnia and improving sleep quality (a systematic review). S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):57-63
Sleep deprivation and the deve­lopment of oxidative stress in animal models. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):124-129
Psycho-emotional state and self-reported sleep quality in students with bimo­dality of the ability to be active in the morning and evening in the sleep—wake cycle. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):130-134
Abstract:

The development of views on cerebral activation in the wakefulness—sleep cycle, starting with the work of Constantin von Economo, is considered. The emphasis is on the cyclic activation of high-amplitude discharges in sleep, which, with known assumptions, can include K-complexes, as well as patterns of delta-like waves. Considering the participation of the peripheral nervous system in this, the integrative role of cyclic activation of high-amplitude discharges in the organization of the sleep—wake cycle is discussed.

Keywords:

sleep—wake cycle
cyclic activation of high-amplitude discharges
K-complexes
delta-like waves

Authors:

Verbitsky E.V.

Southern Scientific Center of the Russian Academy of Sciences

Arapova Yu.Yu.

Rostov State Medical University

Received:

11.03.2024

Accepted:

01.04.2024

Close metadata

References:

  1. Kovalzon VM. Neurobiology wakefulness and sleep. M.: URSS; 2024. (In Russ.).
  2. Kryger M, Goldstein CA, Roth Th, Dement WC. Principles and practice of sleep medicine. Seven Edition. Philadelphia: ELSEVIER; 2022.
  3. Kovalzon VM. Ascending reticular activating system of the brain. Transl Neurosci Clin. 2016;2(4):275-285.  https://doi.org/10.18679/CN11-6030_R.2016.034
  4. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology, and Technical Specifications. Scoring Manual Version 2016-v.2.3.0. Accessed June 1, 2019. https://rtsleepworld.com
  5. Ferini-Strambi L, Bianchi A, Zucconi M, Oldani A. The impact of cyclic alternating pattern on heart rate variability during sleep in healthy young adults. Clin Neurophysiol. 2000;111(1):99-101.  https://doi.org/10.1016/s1388-2457(99)00212-6
  6. Sforza E, Chapotot F, Lavoie S, et al. Heart rate activation during spontaneous arousals from sleep: effect of sleep deprivation. Clin Neurophysiol. 2004;115(11):2442-2451. https://doi.org/10.1016/j.clinph.2004.06.002
  7. American Sleep Disorders Association. EEG arousal: scoring rules and examples. Sleep. 1992;15:174-184. 
  8. Halasz P, Terzano M, Parrino L, Bodizs R. The nature of arousal in sleep. J Sleep Res. 2004;13(1):1-23.  https://doi.org/10.1111/j.1365-2869.2004.00388.x
  9. Halasz P. K-complex, a reactive EEG graphoelement of NREM sleep: an old chap in a new garment. Sleep Med Rev. 2005;9(5):391-412.  https://doi.org/10.1016/j.smrv.2005.04.003
  10. Jahnke K, von Wegner F, Morzelewski A, et al. To wake or not to wake? The two-sided nature of the human K-complex. Neuroimage. 2012;59(2):1631-1638. https://doi.org/10.1016/j.neuroimage.2011.09.013
  11. Terzano MG, Mancia D, Salati MR, et al. The cyclic alternating pattern as a physiologic component of normal NREM sleep. Sleep. 1985;8(2):137-145.  https://doi.org/10.1093/sleep/8.2.137
  12. Terzano MG, Parrino L, Fioriti G, et al. Modifications of sleep structure induced by increasing levels of acoustic perturbation in normal subjects. Electroencephalogr Clin Neurophysiol. 1990;76(1):29-38.  https://doi.org/10.1016/0013-4694(90)90055-o
  13. Terzano MG, Parrino L, Boselli M, et al. CAP components and EEG synchronization in the first 3 sleep cycles. Clin Neurophysiol. 2000;111(2):283-290.  https://doi.org/10.1016/s1388-2457(99)00245-x
  14. Halasz P, Bodizs R, Parrino L, Terzano M. Two features of sleep slow waves: homeostatic and reactive aspects-from long term to instant sleep homeostasis. Sleep Med. 2014;15(10):1184-1195.
  15. Sleep and anxiety. Pod red. Verbitskogo E.V. Rostov-on-Don: Izd-vo YuNTs RAN; 2008. (In Russ.).
  16. Arapova Y, Verbitsky E. The combination of high trait anxiety and female sex is vulnerability factor for sleep disturbances. In: Bradley A., ed. Trait and State Anxiety: Assessment, Predictors and Outcomes. N-Y: Nova Science Pub Inc; 2016;91-116. 
  17. Arapova YuYu, Verbitskiy YeV, Komarova YeF. Studding the night sleep architecture of men and women with high and low levels of trait anxiety. Effektivnaya farmakoterapiya. 2023;199(41):20-24. (In Russ.).
  18. Sysoeva YuYu, Verbitskii EV. Influence of the level personal anxiety on sleep EEG of men and women. Fiziol Cheloveka. 2013;39(6):106-114. (In Russ.). https://doi.org/10.7868/S013116461306012X
  19. Sysoeva YuYu, Verbitskii EV. Kharakter aktivatsii mozga vo vremya nochnogo sna svyazan s lichnostnoi trevozhnost’yu individuuma. Doklady akademii nauk. 2015;461(2):236-238. (In Russ.). https://doi.org/10.7868/S0869565215080307
  20. Rechtschaffen A, Kales A, eds. A manual of standardized terminology: techniques and scoring stages of human subjects. Los Angeles: UCLA Brain Information Service/Brain Research Institute; 1968.
  21. McNamara F, Lijowska AS, Thach BT. Spontaneous arousal activity in infants during NREM and REM sleep. J Physiol. 2002;538:263-269.  https://doi.org/10.1113/jphysiol.2001.012507
  22. Trinder J, Allen N, Kleiman J, et al. On the nature of cardiovascular activation at an arousal from sleep. Sleep. 2003;26:543-551. 
  23. Karadeniz D, Ondze B, Besset A, Billiard M. EEG arousals and awakenings in relation with periodic leg movements during sleep. J Sleep Res. 2000;9:273-277.  https://doi.org/10.1046/j.1365-2869.2000.00202.x
  24. Black JE, Guilleminault C, Colrain IM, Carrillo O. Upper airway resistance syndrome. Central electroencephalographic power and changes in breathing effort. Am J Respir Crit Care Med. 2000;162:406-411.  https://doi.org/10.1164/ajrccm.162.2.9901026
  25. Terzano MG, Parrino L. Origin and significance of the Cyclic Alternating Pattern (CAP). Sleep Med Rev. 2000;4(1):101-123.  https://doi.org/10.1053/smrv.1999.0083
  26. Martin SE, Wraith PK, Deary IJ, Douglas NJ. The effect of nonvisible sleep fragmentation on daytime function. Am J Resp Crit Care Med. 1997b;155:1596-1601. https://doi.org/10.1164/ajrccm.155.5.9154863
  27. Borbely AA, Achermann P. Sleep homeostasis and models of sleep regulation. In: Kryger MH, Roth T, Dement WC, eds. Principles and practice of sleep medicine. 3rd eds. Philadelphia: W.B. Saunders Company; 2000;377-390. 
  28. Manconi M, Garcia-Borreguero D, Schormair B, et al. Restless legs syndrome. Nat Rev Dis Primers. 2021;7(1):80-96.  https://doi.org/10.1038/s41572-021-00311-z
  29. Kuang B, Li D, Lobbezoo F, et al. Associations between sleep bruxism and other sleep-related disorders in adults: a systematic review. Sleep Med. 2022;89:31-47.  https://doi.org/10.1016/j.sleep.2021.11.008
  30. Milioli G, Bosi M, Grassi A, et al. Can sleep microstructure improve diagnosis of OSAS? Integrative information from CAP parameters. Arch Ital Biol. 2015;153(2-3):194-203.  https://doi.org/10.12871/0003982920152344
  31. Parrino L, Smerieri A, Spaggiari MC, Terzano MG. Cyclic alternating pattern (CAP) and epilepsy during sleep: how a physiological rhythm modulates a pathological event. Clin Neurophysiol. 2000;111(2):S39-46.  https://doi.org/10.1016/s1388-2457(00)00400-4
  32. Chouvarda I, Mendez MO, Rosso V, et al. Cyclic alternating patterns in normal sleep and insomnia: structure and content differences. IEEE Trans Neural Syst Rehabil Eng. 2012;20(5):642-652.  https://doi.org/10.1109/TNSRE.2012.2208984
  33. Valocordin-Doxylamine is a new product on the pharmaceutical market for sleeping pills. ratov. Based on materials from the Representative Office of Crevel Meuselbach GmbH (Moscow). Remedium Magazine. Volga region. 2015;2(132):32-34. (In Russ.).
  34. Instruktsiya po klinicheskomu primeneniyu preparata Valokordin-Doksilamin. Spravochnik lekarstvennykh sredstv. Ssylka aktivna na 01.03.24. (In Russ.). https://www.vidal.ru/drugs/valocordin-doxilamin_29611?yasclid=lt3g4njvl7308996530
  35. Liborio P, Grassi A, Milioli G. Cyclic alternating pattern in polysomnography: what is it and what does it mean? Curr Opin Pulm Med. 2014;20(6):533-541.  https://doi.org/10.1097/MCP.0000000000000100
  36. Largo R, Lopes M, Spruyt K, et al. Visual and automatic classification of the cyclic alternating pattern in electroencephalography during sleep. Braz J Med Biol Res. 2019;52(3):e8059-e8068. https://doi.org/10.1590/1414-431X20188059
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.