Locked-in syndrome is a rare neurological disorder. It is characterized by tetraparesis, paralysis of facial and masticatory muscles, anarthria and pseudobulbar syndrome with possible preservation of vertical movements of the eyeballs and blinking, as well as preservation of consciousness. A serious problem with the «locked-in person» syndrome is the inability of the patient to socialize, which causes him to experience no less suffering than from physical limitations. Modern comprehensive rehabilitation of patients, the maximum possible socialization, and the provision of electronic devices to maintain contact with the outside world increase the chances of improving the condition. The life expectancy of patients directly depends on the cause of the disease, concomitant somatic pathology, the quality of medical care, and proper support from loved ones. A case of a patient with locked-in syndrome, which developed as a result of cardioembolic ischemic stroke, is presented, and the dynamics of the condition against the background of rehabilitation measures is described.