Современные подходы к клинической диагностике и лечению мультисистемных дегенераций, связанных с накоплением тау-протеина

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Патология тау-белка лежит в основе развития широкого спектра нейродегенеративных заболеваний, которые обозначаются как таупатии. В основе развития таупатии лежит изменение конформации тау-протеина с последующей агрегацией и дезорганизацией деятельности клетки, в конечном итоге приводящее к ее гибели. Наряду с болезнью Альцгеймера к тау-патиям относятся такие мультисистемные дегенерации, как прогрессирующий надъядерный паралич, кортикобазальный синдром и лобно-височная дегенерация, а также некоторые недавно описанные заболевания, например, возраст-ассоциированные первичные таупатии и др. В представленном обзоре рассмотрены современные представления о патогенезе различных форм нейродегенеративной патологии, связанной с накоплением тау-протеина. Обсуждаются возможности их клинической диагностики и существующие подходы к терапии.

Ключевые слова:

таупатия

прогрессирующий надъядерный паралич

кортикобазальная дегенерация

критерии диагностики

болезнь с аргирофильной зернистостью

Авторы:

Васенина Е.Е.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

Левин О.С.

ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России

Даты поступления:

06.07.2020

Даты принятия в печать:

09.09.2020

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