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Trusova N.A.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

Clinical significance and possibilities of therapy of post-stroke depression

Authors:

Trusova N.A., Levin O.S.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(9‑2): 60‑67

DOI: 10.17116/jnevro201911909260

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CLINICAL SIGNIFICANCE AND POSSIBILITIES OF THERAPY OF POST-STROKE DEPRESSION
CLINICAL SIGNIFICANCE AND POSSIBILITIES OF THERAPY OF POST-STROKE DEPRESSION

To cite this article:

Trusova NA, Levin OS. Clinical significance and possibilities of therapy of post-stroke depression. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(9‑2):60‑67. (In Russ.)
https://doi.org/10.17116/jnevro201911909260

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Abstract:

Depression often complicates the course of the post-stroke period, adversely affecting the functional recovery and quality of life of patients, and is associated with an increased risk of mortality. Over the recent years, the role of inflammatory processes, genetics, white matter damage, cerebrovascular reactivity disorders, changes in the level of monoamines and cortisol, impaired neuroplasticity and glutamate neurotransmission in the pathophysiological mechanisms of post-stroke depression (PSD) is increasingly discussed. Randomized clinical trials (RCTs) have shown that antidepressants are highly effective in the treatment and prevention of PSD. The action of antidepressants, in particular selective serotonin reuptake inhibitors (SSRIs), can be directed to the main pathophysiological processes of post-stroke depression. Treatment of PSD with antidepressants not only reduces the severity of depression, but also improves the functional state, rehabilitation and quality of life of patients.

Keywords:

post-stroke depression
pathophysiology
antidepressants
SSRIs

Authors:

Trusova N.A.

Kafedra nevrologii Rossiĭskoĭ meditsinskoĭ akademii poslediplomnogo obrazovaniia, Moskva

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

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