Clinical and neuroimaging heterogeneity of dementia with Lewy bodies

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Objective. To study clinical characteristics of dementia with Lewy bodies (DLB) depending on neuropsychological, neuroimaging and concomitant cerebrovascular changes as well as on the character of disease onset. Material and methods. Forty-five patients with DLB (25 men and 20 women, men age 72.9±7.2 years, illness duration 2.9±2.2) were studied. The diagnosis was made according to international criteria (McKeith, et al, 2017). MRI, clinical/neurological examination and psychometric scales were used. Results and conclusion. Clinical, neuropsychological and neuroimaging results reveal the heterogeneity of DLB, which remains poorly investigated. An analysis of the clinical picture, cognitive profile, neuropsychiatric changes and MRI results identified three subtypes of DLB course: 1) typical; 2) with early psychotic manifestation; 3) atypical (mixed). This approach may improve the diagnosis of DLB, prognosis of disease course and treatment effectiveness.

Keywords:

dementia with Lewy bodies

cognitive impairment

dementia

neurodegenerative diseases

Authors:

Chimagomedova A.Sh.

Russian Medical Academy of Postgraduate Education, Moscow, Russia

Zorina N.A.

Botkin City Clinical Hospital, Moscow, Russia

Arablinskiĭ A.V.

Otdel luchevoĭ diagnostiki gorodskoĭ klinicheskoĭ bol'nitsy im. S.P. Botkina, Moskva

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

SPIN RSCI: 5342-1373
Scopus AuthorID: 57147160800
ORCID: 0000-0003-3872-5923

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