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Anuriev A.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Russian Medical Academy of Continuing Professional Education, Irkutsk, Russia

Gorbachev V.I.

Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia, Irkutsk, Russia

Hypoxic-ischemic brain damage in premature newborns

Authors:

Anuriev A.M., Gorbachev V.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(8‑2): 63‑69

DOI: 10.17116/jnevro201911908263

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Table of contents

HYPOXIC-ISCHEMIC BRAIN DAMAGE IN PREMATURE NEWBORNS
HYPOXIC-ISCHEMIC BRAIN DAMAGE IN PREMATURE NEWBORNS

To cite this article:

Anuriev AM, Gorbachev VI. Hypoxic-ischemic brain damage in premature newborns. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(8‑2):63‑69. (In Russ.)
https://doi.org/10.17116/jnevro201911908263

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

One of the main causes of cerebral dysfunction in premature newborns is hypoxia. High mortality and lifelong morbidity in these children is a frequent result of neonatal hypoxic brain damage. The article presents some data on the prevalence of neurological diseases that have arisen in the perinatal period, and highlights the key etiological factors leading to hypoxia in both the intranatal and early postnatal periods. The pathogenesis of hypoxic-ischemic brain lesions in premature infants is described in detail. At the same time, more careful consideration is given to the glutathione system, which protects against lipid peroxidation, the glutamate-calcium cascade, and the excitotoxicity mediated by it, as well as the processes of necrosis and apoptosis of nerve cells. The advantages and disadvantages of modern methods for diagnosing cerebral lesions are noted, and the principles of treatment of these disorders are analyzed.

Keywords:

hypoxic-ischemic encephalopathy
premature newborns
cerebral disorders
hypoxia

Authors:

Anuriev A.M.

Irkutsk State Medical Academy of Postgraduate Education — Branch Campus of the Russian Medical Academy of Continuing Professional Education, Irkutsk, Russia

Gorbachev V.I.

Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia, Irkutsk, Russia

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