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Gan'kina O.A.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Vasenina E.E.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Pokhabov D.D.

Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia;
Siberian Research and Clinical Centre, Krasnoyarsk, Russia

Voronov D.B.

Regional Clinical and Diagnostic Center, Rostov-on-Don, Russia

Zhukova I.A.

Siberian State Medical University, Tomsk

Bajtimerov A.R.

RB City Hospital №21, Ufa, Russia

Radiuk M.A.

GBOU VPO "Volgogradskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii, Volgograd

Bojenkina T.V.

Federal Sibirian Research Center, Krasnoyarsk, Russia

Razdorskaya V.V.

Razumovsky Saratov State Medical University, Saratov, Russia

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

Possibilities of retention of work capacity in patients with Parkinson’s disease

Authors:

Gan'kina O.A., Vasenina E.E., Pokhabov D.D., Voronov D.B., Zhukova I.A., Bajtimerov A.R., Radiuk M.A., Bojenkina T.V., Razdorskaya V.V., Levin O.S.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6‑2): 95‑98

DOI: 10.17116/jnevro201811806295

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Table of contents

POSSIBILITIES OF RETENTION OF WORK CAPACITY IN PATIENTS WITH PARKINSON’S DISEASE
POSSIBILITIES OF RETENTION OF WORK CAPACITY IN PATIENTS WITH PARKINSON’S DISEASE

To cite this article:

Gan'kina OA, Vasenina EE, Pokhabov DD, et al. . Possibilities of retention of work capacity in patients with Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6‑2):95‑98. (In Russ.)
https://doi.org/10.17116/jnevro201811806295

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
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Objective. To study the efficacy of replacement of the single daily dose of two-component levodopa by three-component levodopa in work capable patients with Parkinson’s disease with motor fluctuations during the most active working hours. Material and methods. The study included 157 patients from 19 Russian centers specialized in extrapyramidal pathology. The period of highest working activity was analyzed in all patients. In these patients, the previous treatment with two-component levodopa was replaced by three-component levodopa in the equivalent dose. Other antiparkinsonian treatment remained unchanged during the study period. The duration of the study was 1 month. Results and conclusion. The single replacement of two-component levodopa by stalevo allows increasing the optimal working activity by 19% and improving patient’s state.

Keywords:

Parkinson’s disease
L-DOPA
stalevo

Authors:

Gan'kina O.A.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Vasenina E.E.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Pokhabov D.D.

Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia;
Siberian Research and Clinical Centre, Krasnoyarsk, Russia

Voronov D.B.

Regional Clinical and Diagnostic Center, Rostov-on-Don, Russia

Zhukova I.A.

Siberian State Medical University, Tomsk

Bajtimerov A.R.

RB City Hospital №21, Ufa, Russia

Radiuk M.A.

GBOU VPO "Volgogradskiĭ gosudarstvennyĭ meditsinskiĭ universitet" Minzdrava Rossii, Volgograd

Bojenkina T.V.

Federal Sibirian Research Center, Krasnoyarsk, Russia

Razdorskaya V.V.

Razumovsky Saratov State Medical University, Saratov, Russia

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

List of references:

  1. Levin OS, Fedorova NV. Parkinsons disease. M.: MEDpress-inform; 2016. (In Russ.)
  2. Sapronova MR, Shnaider NA. The epidemiological, clinical, and genetic characteristics of Parkinson’s disease (in case of Zheleznogorsk). Neurology, Neuropsychiatry, Psychosomatics. 2014;6(4):59-64. (In Russ.) https://doi.org/10.14412/2074-2711-2014-4-59-64
  3. Vasenina EE, Gankina OA, Kulua TK, Levin OS. Optimisation of parkinsons disease treatment in period of maximum days activity. Eldery patient. 2016;2(6):56-62. (In Russ.)
  4. Postuma R, Berg D, Stern M, Poewe W, Olanow C, Oertel W, Obeso J, Marek K, Litvan I, Lang A, Halliday G, Goetz C, Gasser T, Dubois B, Chan P, Bloem B, Adler C and Deuschl G. MDS clinical diagnostic criteria for Parkinson’s disease. Movement Disorders. 2015;30(12):1591-1601. https://doi.org/10.1002/mds.26424
  5. Trudelle P. Unified Parkinson Disease Rating Scale (UPDRS). Kinésithérapie, la Revue. 2006;6(51):20-24. https://doi.org/10.1016/s1779-0123(06)74622-8
  6. Kleiner-Fisman G, Martine R, Lang A, Stern M. Development of a Non-Motor Fluctuation Assessment Instrument for Parkinson Disease. Parkinson’s Disease. 2011;292719:1-13. https://doi.org/10.4061/2011/292719
  7. Koerts J, König M, Tucha L, Tucha O. Working capacity of patients with Parkinson’s disease — A systematic review. Parkinsonism & Related Disorders. 2016;27:9-24. https://doi.org/10.1016/j.parkreldis.2016.03.017
  8. Martikainen K, Luukkaala T, Marttila R. Parkinson’s disease and working capacity. Movement Disorders. 2006;21(12):2187-2191. https://doi.org/10.1002/mds.21171
  9. Keränen T, Kaakkola S, Sotaniemi K, Laulumaa V, Haapaniemi T, Jolma T, Kola H, Ylikoski A, Satomaa O, Kovanen J, Taimela E, Haapaniemi H, Turunen H, Takala A. Economic burden and quality of life impairment increase with severity of PD. Parkinsonism & Related Disorders. 2003;9(3):163-168. https://doi.org/10.1016/s1353-8020(02)00097-4
  10. Murphy R, Tubridy N, Kevelighan H, O’Riordan S. Parkinson’s disease: how is employment affected? Irish Journal of Medical Science. 2013;182(3):415-419. https://doi.org/10.1007/s11845-013-0902-5
  11. Løvereide L, Hagell P. Measuring Life Satisfaction in Parkinson’s Disease and Healthy Controls Using the Satisfaction With Life Scale. PLOS ONE. 2016;11(10):e0163931. https://doi.org/10.1371/journal.pone.0163931
  12. Banks P, Lawrence M. The Disability Discrimination Act, a necessary, but not sufficient safeguard for people with progressive conditions in the workplace? The experiences of younger people with Parkinson’s disease. Disability and Rehabilitation. 2006;28(1):13-24. https://doi.org/10.1080/09638280500165120
  13. Jasinska-Myga B, Heckman M, Wider C, Putzke J, Wszolek Z, Uitti R. Loss of ability to work and ability to live independently in Parkinson’s disease. Parkinsonism & Related Disorders. 2012;18(2):130-135. https://doi.org/10.1016/j.parkreldis.2011.08.022
  14. Armstrong M, Gruber-Baldini A, Reich S, Fishman P, Lachner C, Shulman L. Which features of Parkinson’s disease predict earlier exit from the workforce? Parkinsonism & Related Disorders. 2014;20(11):257-1259. https://doi.org/10.1016/j.parkreldis.2014.08.005
  15. Johnson S, Davis M, Kaltenboeck A, Birnbaum H, Grubb E, Tarrants M, Siderowf A. Early Retirement and Income Loss in Patients with Early and Advanced Parkinsonʼs Disease. Applied Health Economics and Health Policy. 2011;9(6):367-376. https://doi.org/10.2165/11596900-000000000-00000
  16. Gilbert F. Deep Brain Stimulation: From Parkinson treatment to personality enhancement? CyberTherapy &Rehabilitation Magazine. 2010;2:17-18. https://doi.org/10.1037/e530522011-004
  17. Korchounov A, Bogomazov G. Employment, medical absenteeism, and disability perception in Parkinson’s disease: A pilot double-blind, randomized, placebo-controlled study of entacapone adjunctive therapy. Movement Disorders. 2006:21(12):2220-2224. https://doi.org/10.1002/mds.21123

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