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Skalny A.V.

Peoples Friendship University of Russia, Moscow, Russia;
Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia;
Yaroslavl State University, Yaroslavl, Russia;
Trace Element Institute of UNESCO, Lyon, France

Simashkova N.V.

Scientific center of mental health, Moscow, Russia

Skalnaya M.G.

RUDN University, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

Chernova L.N.

Peoples Friendship University of Russia, Moscow, Russia

Tinkov A.A.

RUDN University, Moscow, Russia;
P.G. Demidov State University of Yaroslavl, Yaroslavl, Russia

Mercury and autism spectrum disorders

Authors:

Skalny A.V., Simashkova N.V., Skalnaya M.G., Klyushnik T.P., Chernova L.N., Tinkov A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5‑2): 75‑79

DOI: 10.17116/jnevro20181185275

Read: 5194 times

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Table of contents

MERCURY AND AUTISM SPECTRUM DISORDERS
MERCURY AND AUTISM SPECTRUM DISORDERS

To cite this article:

Skalny AV, Simashkova NV, Skalnaya MG, Klyushnik TP, Chernova LN, Tinkov AA. Mercury and autism spectrum disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(5‑2):75‑79. (In Russ.)
https://doi.org/10.17116/jnevro20181185275

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

The authors present a review of literature on the involvement of perinatal and postnatal mercury exposure in the pathogenesis of autistic spectrum disorders (ASD). A number of studies have shown a reliable association between perinatal and postnatal exposure to mercury and ASD development aa well as clinical and laboratory markers of the severity of these disorders. However the association was not confirmed in other studies. Such contradictions may be explained by differences in the composition of study groups, including geographical characteristics, and the influence of the factors related to mercury neurotoxicity.

Keywords:

mercury
autism spectrum disorders
biological substrates for mercury determination
mercury neurotoxicity

Authors:

Skalny A.V.

Peoples Friendship University of Russia, Moscow, Russia;
Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russia;
Yaroslavl State University, Yaroslavl, Russia;
Trace Element Institute of UNESCO, Lyon, France

Simashkova N.V.

Scientific center of mental health, Moscow, Russia

Skalnaya M.G.

RUDN University, Moscow, Russia

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

Chernova L.N.

Peoples Friendship University of Russia, Moscow, Russia

Tinkov A.A.

RUDN University, Moscow, Russia;
P.G. Demidov State University of Yaroslavl, Yaroslavl, Russia

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References:

  1. Simashkova NV, Makushkin EV. Rasstroistva autisticheskogo spektra: diagnostika, lechenie, nablyudenie: Klinicheskie rekomendatsii (protokol lecheniya). M.: Federal’nyi meditsinskii issledovatel’skii tsentr psikhiatrii i narkologii im. V.P. Serbskogo, Nauchnyi tsentr psikhicheskogo zdorov’ya, Rossiiskoe obshchestvo psikhiatrov; 2015. (In Russ.)
  2. Fombonne E. The epidemiology of autism: a review. Psychol Med. 1999;29:769-786. https://doi.org/10.1017/S0033291799008508
  3. Zablotsky B, Black LI, Maenner MJ, Schieve LA, Blumberg SJ. Estimated prevalence of autism and other developmental disabilities following questionnaire changes in the 2014 National Health Interview Survey. Natl Health Stat Report. 2015;87:1-20.
  4. Hertz-Picciotto I, Delwiche L. The rise in autism and the role of age at diagnosis. Epidemiology. 2009;20(1):84-90. https://doi.org/10.1097/EDE.0b013e3181902d15
  5. Matelski L, Van de Water J. Risk factors in autism: Thinking outside the brain. J Autoimmun. 2015;67:1-7. https://doi.org/10.1016/j.jaut.2015.11.003
  6. Kalkbrenner AE, Windham GC, Serre ML, Akita Y, Wang X, Hoffman K, Daniels JL. Particulate matter exposure, prenatal and postnatal windows of susceptibility, and autism spectrum disorders. Epidemiology. 2015;26(1):30-42. https://doi.org/10.1097/EDE.0000000000000173
  7. Kern JK, Geier DA, Sykes LK, Haley BE, Geier M.R. The relationship between mercury and autism: A comprehensive review and discussion. J Trace Elem Med Biol. 2016;37:8-24. https://doi.org/10.1016/j.jtemb.2016.06.002
  8. Bernard S, Enayati A, Redwood L, Roger H, Binstock T. Autism: a novel form of mercury poisoning. Medical Hypotheses. 2001;56(4):462-471. https://doi.org/10.1054/mehy.2000.1281
  9. Kern JK, Geier DA, Audhya T, King PG, Sykes LK, Geier MR. Evidence of parallels between mercury intoxication and the brain pathology in autism. Acta Neurobiol Exp. 2012;72:113-153. https://doi.org/10.1016/j.jtemb.2016.06.002
  10. Ye BS, Leung AOW, Wong MH. The association of environmental toxicants and autism spectrum disorders in children. Environ Pollut. 2017;227:234-242. https://doi.org/10.1016/j.envpol.2017.04.039
  11. Morris G, Puri BK, Frye RE, Maes M. The putative role of environmental mercury in the pathogenesis and pathophysiology of autism spectrum disorders and subtypes. Mol Neurobiol. 2018;55(6):4834-4856. https://doi.org/10.1007/s12035-017-0692-2
  12. Geier DA, Kern JK, Geier MR. Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink. J Trace Elem Med Biol. 2017;42:18-24. https://doi.org/10.1016/j.jtemb.2017.03.005
  13. Geier DA, Kern JK, Geier MR. A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity. Acta Neurobiol Exp (Wars). 2009;69(2):189-197.
  14. Ryu J, Ha EH, Kim BN, Ha M, Kim Y, Park H, Hong YC, Kim KN. Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5years of age: The Mothers and Children’s Environmental Health (MOCEH) study. Sci Total Environ. 2017;605-606:251-257. https://doi.org/10.1016/j.scitotenv.2017.06.227
  15. Palmer RF, Blanchard S, Wood R. Proximity to point sources of environmental mercury release as a predictor of autism prevalence. Health & place. 2009;15(1):18-24. https://doi.org/10.1016/j.healthplace.2008.02.001
  16. Dickerson AS, Rahbar MH, Han I, Bakian AV, Bilder DA, Harrington RA, Tian LH. Autism spectrum disorder prevalence and proximity to industrial facilities releasing arsenic, lead or mercury. Science of the Total Environment. 2015;536:245-251. https://doi.org/10.1016/j.scitotenv.2015.07.024
  17. Fido A, Al-Saad S. Toxic trace elements in the hair of children with autism. Autism. 2005;9(3):290-298. https://doi.org/10.1177/1362361305053255
  18. Al-Ayadhi LY. Heavy metals and trace elements in hair samples of autistic children in central Saudi Arabia. Neurosciences (Riyadh). 2005;10:213-218.
  19. El-Baz F, Elhossiny RM, Elsayed AB, Gaber GM. Hair mercury measurement in Egyptian autistic children. Egypt J Med Human Genet. 2010;11:135-141. https://doi.org/10.1016/j.ejmhg.2010.10.007
  20. Yassa HA. Autism: A form of lead and mercury toxicity. Environ Toxicol Pharmacol. 2014;38:1016-1024. https://doi.org/10.1016/j.etap.2014.10.005
  21. Mohamed FE, Zaky EA, El-Sayed AB, Elhossieny RM, Zahra SS, Salah Eldin W, Youssef WY, Khaled RA, Youssef AM. Assessment of hair aluminum, lead, and mercury in a sample of autistic Egyptian children: environmental risk factors of heavy metals in autism. Behav Neurol. 2015;545-674. https://doi.org/10.1155/2015/545674
  22. Hodgson NW, Waly MI, Al-Farsi YM, Al-Sharbati MM, Al-Farsi O, Ali A, Ouhtit A, Zang T, Zhou ZS, Deth RC. Decreased glutathione and elevated hair mercury levels are associated with nutritional deficiency-based autism in Oman. Exp Biol Med. (Maywood). 2014;239:697-706. https://doi.org/10.1177/1535370214527900
  23. Priya MDL, Geetha A. Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism. Biological trace element research. 2011;142(2):148-158. https://doi.org/10.1007/s12011-010-8766-2
  24. Geier DA, Kern JK, King PG, Sykes LK, Geier MR. Hair toxic metal concentrations and autism spectrum disorder severity in young children. International Journal of Environmental Research and Public Health. 2012;9(12):4486-4497. https://doi.org/10.3390/ijerph9124486
  25. Adams JB, Romdalvik J, Ramanujam VS, Legator MS. Mercury, lead, and zinc in baby teeth of children with autism versus controls. Journal of Toxicology and Environmental Health. 2007;70(12):1046-1051. https://doi.org/10.1080/15287390601172080
  26. Li H, Li H, Li Y, Liu Y, Zhao, Z. Blood Mercury, Arsenic, Cadmium, and Lead in Children with Autism Spectrum Disorder. Biol Trace Elem Res. 2018;181:31-37. https://doi.org/10.1007/s12011-017-1002-6
  27. El-Ansary A, Bjørklund G, Tinkov AA, Skalny AV, Al Dera H. Relationship between selenium, lead, and mercury in red blood cells of Saudi autistic children. Metabolic brain disease. 2017;32(4):1073-1080. https://doi.org/10.1007/s11011-017-9996-1
  28. Mostafa GA, Refai TM. Antineuronal antibodies in autistic children: relation to blood mercury. Egypt J Pediatr Allergy Immunol. 2007;5:21-30.
  29. Mostafa GA, Al-Ayadhi LY. The possible association between elevated levels of blood mercury and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children. J Clin Cell Immunol. 2015;6(2): 310. https://doi.org/10.4172/2155-9899.1000310
  30. Mostafa GA, Bjørklund G, Urbina MA, AL-Ayadhi LY. The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder. Metab Brain Dis. 2016;31:593-599. https://doi.org/10.1007/s11011-015-9784-8
  31. Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R, Van de Water J. Correlations between gene expression and mercury levels in blood of boys with and without autism. Neurotox Res. 2011;19:31-48. https://doi.org/10.1007/s12640-009-9137-7
  32. Blaurock-Busch E, Amin OR, Rabah T. Heavy metals and trace elements in hair and urine of a sample of arab children with autistic spectrum disorder. Maedica. 2011;6(4):247.
  33. Bradstreet J, Geier DA, Kartzinel JJ, Adams JB, Geier MR. A case-control study of mercury burden in children with autistic spectrum disorders. J Am Phys Surg. 2003;8(3):76-79.
  34. Geier DA, Geier MR. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. Journal of Toxicology and Environmental Health, Part A. 2007;70(20):1723-1730. https://doi.org/10.1080/15287390701457712
  35. Adams J, Howsmon DP, Kruger U, Geis E, Gehn E, Fimbres V, Quig D. Significant association of urinary toxic metals and autism-related symptoms A nonlinear statistical analysis with cross validation. PloS one. 2017;12(1): 0169526. https://doi.org/10.1371/journal.pone.0169526
  36. Geier DA, Geier M.R. A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure. Neurotox Res. 2006;10:57-64. https://doi.org/10.1007/BF03033334
  37. Khaled EM, Meguid NA, Bjørklund G, Gouda A, Bahary MH, Hashish A, Sallam NM, Chirumbolo, S., El-Bana, M.A. Altered urinary porphyrins and mercury exposure as biomarkers for autism severity in Egyptian children with autism spectrum disorder. Metabol Brain Dis. 2016;31:1419-1426. https://doi.org/10.1007/s11011-016-9870-6
  38. Jafari T, Rostampour N, Fallah AA, Hesami A. The association between mercury levels and autism spectrum disorders: A systematic review and meta-analysis. J Trace Elem Med Biol. 2017;44:289-297. https://doi.org/10.1016/j.jtemb.2017.09.002
  39. Saghazadeh A, Rezaei N. Systematic review and meta-analysis links autism and toxic metals and highlights the impact of country development status: Higher blood and erythrocyte levels for mercury and lead, and higher hair antimony, cadmium, lead, and mercury. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2017;79:340-368. https://doi.org/10.1016/j.pnpbp.2017.07.011
  40. McKean SJ, Bartell SM, Hansen RL, Barfod GH, Green PG, Hertz-Picciotto I. Prenatal mercury exposure, autism, and developmental delay, using pharmacokinetic combination of newborn blood concentrations and questionnaire data: a case control study. Environ Health. 2015;14:62. https://doi.org/10.1186/s12940-015-0045-4
  41. Holmes AS, Blaxill MF, Haley BE. Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol. 2003;22:277-285. https://doi.org/10.1080/10915810305120
  42. Adams JB, Romdalvik J, Levine KE, Hu LW. Mercury in first-cut baby hair of children with autism versus typically-developing children. Toxicol Environ Chem. 2008;90:739-753. https://doi.org/10.1080/02772240701699294
  43. Skalny AV, Simashkova NV, Klyushnik TP, Grabeklis AR, Bjørklund G, Skalnaya MG, Nikonorov AA, Tinkov A.A. Hair toxic and essential trace elements in children with autism spectrum disorder. Metab Brain Dis. 2017;32:195-202. https://doi.org/10.1007/s11011-016-9899-6
  44. Skalny AV, Simashkova NV, Klyushnik TP, Grabeklis AR, Radysh IV, Skalnaya MG, Tinkov AA. Analysis of hair trace elements in children with autism spectrum disorders and communication disorders. Biol Trace Elem Res. 2017;177:215-223. https://doi.org/10.1007/s12011-016-0878-x
  45. Adams JB, Holloway CE, George F, Quig D. Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers. Biological trace element research. 2006;110(3):193-209. https://doi.org/10.1385/BTER:110:3:193
  46. Majewska MD, Urbanowicz E, Rok-Bujko P, Namyslowska I, Mierzejewski P. Age-dependent lower or higher levels of hair mercury in autistic children than in healthy controls. Acta neurobiologiae experimentalis. 2010;70(2):196-208.
  47. Ip P, Wong V, Ho M, Lee J, Wong W. Mercury exposure in children with autistic spectrum disorder: case-control study. J Child Neurol. 2004;19:431-434. https://doi.org/10.1177/088307380401900606
  48. DeSoto MC, Hitlan RT. Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set. Journal of Child Neurology. 2007;22(11):1308-1311. https://doi.org/10.1177/0883073807307111
  49. Hertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah IN. Blood mercury concentrations in CHARGE Study children with and without autism. Environmental Health Perspectives. 2010;118(1):161. https://doi.org/10.1289/ehp.0900736
  50. Rahbar MH, Samms-Vaughan M, Loveland KA, Ardjomand-Hessabi M, Chen Z, Bressler J, Lalor GC. Seafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders. Neurotoxicity research. 2013;23(1):22-38. https://doi.org/10.1007/s12640-012-9321-z
  51. Yau VM, Green PG, Alaimo CP, Yoshida CK, Lutsky M, Windham GC, Croen LA. Prenatal and neonatal peripheral blood mercury levels and autism spectrum disorders. Environmental research. 2014;133:294-303. https://doi.org/10.1016/j.envres.2014.04.034
  52. Wright B, Pearce H, Allgar V, Miles J, Whitton C, Leon I, Lewis J. A comparison of urinary mercury between children with autism spectrum disorders and control children. PLoS One. 2012;7(2):29547. https://doi.org/10.1371/journal.pone.0029547
  53. Soden SE, Lowry JA, Garrison CB, Wasserman GS. 24-hour provoked urine excretion test for heavy metals in children with autism and typically developing controls, a pilot study. Clinical Toxicology. 2007;45(5):476-481. https://doi.org/10.1080/15563650701338195
  54. Dickerson AS, Rotem RS, Christian MA, Nguyen VT, Specht AJ. Potential Sex Differences Relative to Autism Spectrum Disorder and Metals. Current environmental health reports. 2017;4(4):405-414. https://doi.org/10.1007/s40572-017-0164-x
  55. Kern JK, Geier DA, Deth RC, Sykes LK, Hooker BS, Love JM, Geier MR. Systematic Assessment of Research on Autism Spectrum Disorder (ASD) and Mercury Reveals Conflicts of Interest and the Need for Transparency in Autism Research. Science and engineering ethics. 2017;23(6):1691-1718. https://doi.org/10.1007/s11948-017-9983-2
  56. Kern JK, Grannemann BD, Trivedi MH, Adams JB. Sulfhydryl-reactive metals in autism. Journal of Toxicology and Environmental Health, Part A. 2007;70(8):715-721. https://doi.org/10.1080/15287390601188060
  57. Vergilio CS, Carvalho CEV, Melo EJT. Mercury-induced dysfunctions in multiple organelles leading to cell death. Toxicol In Vitro. 2015;29:63-71. https://doi.org/10.1016/j.tiv.2014.09.006
  58. Curtis JT, Chen Y, Buck DJ, Davis RL. Chronic inorganic mercury exposure induces sex-specific changes in central TNFα expression: Importance in autism? Neurosci Lett. 2011;504:40-44. https://doi.org/10.1016/j.neulet.2011.08.053
  59. Zhang Y, Gao D, Bolivar VJ, Lawrence DA. Induction of autoimmunity to brain antigens by developmental mercury exposure. Toxicol Sci. 2010;119:270-280. https://doi.org/10.1093/toxsci/kfq334
  60. Kempuraj D, Asadi S, Zhang B, Manola A, Hogan J, Peterson E, Theoharides TC. Mercury induces inflammatory mediator release from human mast cells. J Neuroinflammation. 2010;7:20. https://doi.org/10.1186/1742-2094-7-20
  61. Bjørklund G, Aaseth J, Ajsuvakova OP, Nikonorov AA, Skalny AV, Skalnaya MG, Tinkov AA. Molecular interaction between mercury and selenium in neurotoxicity. Coord Chem Rev. 2017;332:30-37. https://doi.org/10.1016/j.ccr.2016.10.009
  62. El-Ansary A, Al-Ayadhi L. GABAergic/glutamatergic imbalance relative to excessive neuroinflammation in autism spectrum disorders. J Neuroinflammation. 2014;11:189. https://doi.org/10.1186/s12974-014-0189-0
  63. Chang JY. Methylmercury causes glial IL-6 release. Neurosci Lett. 2007;416:217-220. https://doi.org/10.1016/j.neulet.2007.01.076
  64. Farina M, Avila DS, Da Rocha JBT, Aschner M. Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury. Neurochem Int. 2013;62:575-594. https://doi.org/10.1016/j.neuint.2012.12.006
  65. Branco V, Canário J, Lu J, Holmgren A, Carvalho C. Mercury and selenium interaction in vivo: effects on thioredoxin reductase and glutathione peroxidase. Free Radic Biol Med. 2012;52:781-793. https://doi.org/10.1016/j.freeradbiomed.2011.12.002
  66. Aguado A, Galán M, Zhenyukh O, Wiggers GA, Roque FR, Redondo S, Tejerina T. Mercury induces proliferation and reduces cell size in vascular smooth muscle cells through MAPK, oxidative stress and cyclooxygenase-2 pathways. Toxicology and applied pharmacology. 2013;268(2):188-200. https://doi.org/10.1016/j.taap.2013.01.030
  67. Carratù MR, Signorile A. Methyl mercury injury to CNS: Mitochondria at the core of the matter? Open Acc Toxicol. 2015;1:555551. https://doi.org/10.19080/OAJT.2015.01.555551
  68. Lu TH, Hsieh SY, Yen CC, Wu HC, Chen KL, Hung DZ, Liu SH. Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury. Toxicol Lett. 2011;204:71-80. https://doi.org/10.1016/j.toxlet.2011.04.013
  69. Xu F, Farkas S, Kortbeek S, Zhang FX, Chen L, Zamponi GW, Syed NI. Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-D-Aspartate receptors. Molecular brain. 2012;5(1):30. https://doi.org/10.1186/1756-6606-5-30
  70. Fitsanakis VA, Aschner M. The importance of glutamate, glycine, and γ-aminobutyric acid transport and regulation in manganese, mercury and lead neurotoxicity. Toxicol Appl Pharmacol. 2005;204:343-354. https://doi.org/10.1016/j.taap.2004.11.013
  71. Pierozan P, Biasibetti H, Schmitz F, Ávila H, Fernandes CG, Pessoa-Pureur R, Wyse AT. Neurotoxicity of methylmercury in isolated astrocytes and neurons: the cytoskeleton as a main target. Mol Neurobiol. 2017;54:5752-5767. https://doi.org/10.1007/s12035-016-0101-2
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