The role of central histamine receptor blockers in the treatment of insomnia

Strigin K.N.

Sechenov First Moscow State Medical University, Moscow, Russia

Authors:

Strigin K.N.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4‑2): 73‑82

DOI: 10.17116/jnevro20181184273

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To cite this article:

Strigin KN. The role of central histamine receptor blockers in the treatment of insomnia. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(4‑2):73‑82. (In Russ.)
https://doi.org/10.17116/jnevro20181184273

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The article analyzes the anatomy, morphological and neurochemical connections and functions of the brain histaminergic system, one of the leading systems in the mechanism maintaining wakefulness. The possibilities of histaminergic system modulating for the treatment of various sleep/wake cycle disorders are discussed. The data of clinical trials on the influence of the histamine H1 receptor antagonist doxylamine on sleep in healthy volunteers and patients with insomnia are considered. The evidence-based efficacy of the drug in sleep disorders is discussed.

Keywords:

sleep

histamine

doxylamine

donormyl

insomnia

Authors:

Strigin K.N.

Sechenov First Moscow State Medical University, Moscow, Russia

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accessed May 22, 2018]. https://www.researchgate.net/publication/236599819 (In Russ.)

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