The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Prakhova L.N.

Il'ves A.G.

Savintseva Zh.I.

Bekhtereva Institute of Human Brain, St. Petersburg, Russia

Mineev K.K.

FGBU "Institut mozga cheloveka im. N.P. Bekhterevoĭ" RAN, Sankt-Peterburg

Nikiforova I.G.

Institut mozga cheloveka imeni N.P. Bekhterevoĭ RAN, Sankt-Peterburg

Rubanik K.S.

Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia

Kataeva G.V.

Institut mozga cheloveka im. N.P. Bekhterevoĭ RAN, Sankt-Peterburg

Neuroprotection therapy of multiple sclerosis with high doses of ethylmethylhydroxypyridine succinate

Authors:

Prakhova L.N., Il'ves A.G., Savintseva Zh.I., Mineev K.K., Nikiforova I.G., Rubanik K.S., Kataeva G.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10‑2): 73‑78

DOI: 10.17116/jnevro201611610273-78

Read: 3553 times

Download PDF (RU)
Contact the author
Table of contents

NEUROPROTECTION THERAPY OF MULTIPLE SCLEROSIS WITH HIGH DOSES OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE
NEUROPROTECTION THERAPY OF MULTIPLE SCLEROSIS WITH HIGH DOSES OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE

To cite this article:

Prakhova LN, Il'ves AG, Savintseva ZhI, Mineev KK, Nikiforova IG, Rubanik KS, Kataeva GV. Neuroprotection therapy of multiple sclerosis with high doses of ethylmethylhydroxypyridine succinate. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(10‑2):73‑78. (In Russ.)
https://doi.org/10.17116/jnevro201611610273-78

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Inte­rnational multicenter randomized double-blind placebo-controlled study asse­ssing the effi­cacy and safety of sequential therapy with Mexi­dol and Mexi­dol FORTE 250 in patients with chro­nic brain ischemia (MEMO): suba­nalysis in patients with arte­rial hype­rtension. Russian Journal of Preventive Medi­cine. 2024;(10):72-83
Low-level laser therapy in multiple scle­rosis: justification and opti­mization methods of application. (Literature review). Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(5):45-56
Obje­ctive stru­ctural and functional moni­toring of poly­peptide reti­nal neuroprotective therapy in diabetic reti­nopathy. Russian Annals of Ophthalmology. 2024;(5):97-104
A pilot study of asso­ciations of markers of glial and neuronal dege­neration with executive functions in alco­hol use diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):74-79
Glial fibrillary acidic protein: is there a rela­tionship with the course of multiple scle­rosis and traumatic brain injury before the onset of multiple scle­rosis?. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):80-84
An indi­vidual approach to the diagnosis and treatment of an acute psychotic condition in a patient with a multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):97-102
Surgical treatment of seco­ndary trigeminal neuralgia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):203-209
Neuroprotective therapy for age-related macu­lar dege­neration. Russian Annals of Ophthalmology. 2024;(6):152-158
Quality of life of patients with multiple scle­rosis in the Smolensk region. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):36-40
Motor beha­vior in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mice model of Parkinson’s disease treated with reco­mbinant spidroin rS1/9 microgel. Mole­cular Gene­tics, Microbiology and Viro­logy. 2024;(4):12-17
Abstract:

Objective. To study the therapeutic action of ethylmethylhydroxypyridine succinate (mexidol) on the neurodegeneration in multiple sclerosis (MS). Material and methods. Fifty-two MS patients and 24 healthy controls were examined using DTI MRI with tractography. Results and conclusion. Ethylmethylhydroxypyridine succinate can prevent the progression of neurodegenerative processes in MS. However, further clinical trials are needed to confirm the results obtained in this study.

Keywords:

multiple sclerosis
neurodegeneration
ethylmethylhydroxypyridine succinate
DTI MRI with tractography

Authors:

Prakhova L.N.

Il'ves A.G.

Savintseva Zh.I.

Bekhtereva Institute of Human Brain, St. Petersburg, Russia

Mineev K.K.

FGBU "Institut mozga cheloveka im. N.P. Bekhterevoĭ" RAN, Sankt-Peterburg

Nikiforova I.G.

Institut mozga cheloveka imeni N.P. Bekhterevoĭ RAN, Sankt-Peterburg

Rubanik K.S.

Bechtereva Institute of Human Brain of Russian Academy of Sciences, St. Petersburg, Russia

Kataeva G.V.

Institut mozga cheloveka im. N.P. Bekhterevoĭ RAN, Sankt-Peterburg

Close metadata

References:

  1. Shmidt TE. Neurodegeneration in multiple sclerosis and the neuroprotective effect of glatiramer acetate: a literature review. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012;9:2:123-128.
  2. Mahad DH, Trapp BD, Lassmann H. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015;14:183-193. Ortiz Genaro G, Pacheco-Moisés Fermín P, Bitzer-Quintero Oscar K, Ramírez-Anguiano Ana C, Flores-Alvarado Luis J, Ramírez-Ramírez Viridiana, Macias-Islas Miguel A, Torres-Sánchez1 Erandis D. Review Article. Immunology and Oxidative Stress in Multiple Sclerosis: Clinical and Basic Approach. Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2013, Article ID 708659, 14 pages. doi: 10.1155/2013/708659
  3. Camara AKS, Lesnefsky EJ, Stowe DF. Potential therapeutic benefits of strategies directed to mitochondria. Antioxid. Redox Signal. 2013;13:279-347. doi: 10.1089/ars.2009.2788
  4. Magonov EP, Prakhova LN, Ilves AG, Kataeva GV, Trofimova TN. Automatic segmentation of brain MRI images: methods and software. HIV Infection and Immunosuppressive Disorders. 2014;6:3:73-77.
  5. Signoretti S, Marmarou A, Tavazzi B. et al. N-acetylaspartate reduction as a measure of injury severity and mitochondrial dysfunction following diffuse traumatic brain injury. J Neurotrauma. 2001;18:977-991. doi: 10.1089/08977150152693683
  6. Bogdan AA, Ilves AG, Kataeva GV, Prakhova LN, Trofimova TN, Stolyarov ID. Regional metabolic changes of supraventricular tissue in patients with relapsing-remitting and secondary-progressive multiple sclerosis. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2015;8:14-17. doi: 10.17116/jnevro20151158214-17
  7. Gonen T, Catalaa II, Babb JS et al. otal brain N-acetylaspartate: a new measure of disease load in MS. Neurology. 2000;54(1):15-19. Adalsteinsson E. et al. 2003. doi: 10.1212/wnl.54.1.15
  8. Корниенко В.Н., Пронин И.Н. Диагностическая нейрорадиология. М.: Издательство «Андреева Т.М.»; 2006.
  9. Sijens PE, Irwan R, Potze JH. Relationships between brain water content and diffusion tensor imaging parameters (apparent diffusion coefficient and fractional anisotropy) in multiple sclerosis. Eur Radiol. 2006;16(4):898-904. doi: 10.1007/s00330-005-0033-0
  10. Mahad DH, Trapp BD, Lassmann H. Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015;14:183-193. doi: doi: 10.1016/S1474-4422(14)70256-X
  11. Voronina TA. Mexidol: the spectrum of pharmacological effects. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012;12:86-90.
  12. Popova NF, Orlova EV, Paschenkov MA, Boiko AN. Clinical-immunological aspects of multiple sclerosis treatment with ethylmethylhydroxypyridine succinate. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2011;8:68-71.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.