Objective. To identify the most informative predictors of delirium tremens severity. Material and methods. A total of 105 patients from a department of urgent drug addiction help of the Chelyabinsk regional addiction hospital were examined. To find the most informative predictors of delirium tremens severity, we studied a relationship between biogenic amine metabolism and changes in cortisol levels in dependence of patients’ condition. The level of catecholamines (adrenaline, noradrenaline, dopamine) and their precursor 3’4-dioxyphenylalanine in blood and daily urine, serotonin and histamine content, thrombocyte monoamine oxidase B activity, urinary tribulin activity, and serum cortisol levels of the patients with different severity of delirium tremens were assessed. Results and conclusion. A prognostic significance of cortisol and blood serotonin levels, and thrombocyte monoamine oxidase activity was demonstrated. A decrease in cortisol levels was the most negative predictor.