Objective. To assess the prognostic value of erythrocyte membrane adrenoreceptor activity in the peripheral blood in the acute phase of ischemic stroke (II). Material and methods. We studied 89 patients with hemispheric atherothrombotic stroke, 49 women and 40 men, aged from 40 to 87 years (mean age 66.69±13.64 years). Results and conclusion. The prospective six-month trial established that the most significant predictors of poor stoke outcome were: age more than 71, severity of stroke in acute phase (IV-V Rankin scale degree), erythrocyte membrane beta-adrenoreception level (EMBR) more than 50 RVU in the acute phase and high EMBR (>40 RVU) in 7-10 days after stroke. Erythrocyte membrane beta-adrenoreception level (EMBR) more than 50 RVU was associated with mortality during the first 6 months after stroke (р=0.0017). Prediction model of stroke based on EMBR level was suggested.