Phage therapy of purulent-inflammatory pathology of the outer and middle ear

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The steady growth of antibiotic resistance of bacteria and, as a result, difficulties in selecting effective drugs determine the search for an alternative strategy for the use of antimicrobials, and therapy based on the use of bacteriophages is such. Phage therapy in otorhinolaryngology is actively used for the treatment of rhinosinusitis, diseases of the pharynx and larynx. However, it should be noted that the use of this group of drugs in the treatment of ear diseases is not sufficiently covered. Currently, institutes and clinics around the world are undergoing many large multicenter studies aimed not only at finding effective bacteriophages against antibiotic-resistant bacteria, but also at isolating their enzymes (lysines), expression of transport proteins, genetic modifications that lead to the restoration of the sensitivity of bacteria to antimicrobial drugs. In this review, we sought to highlight modern works concerning the treatment of inflammatory ear diseases with bacteriophage preparations, the results of microbiological studies conducted in vitro, the main purpose of which was to combat multi-resistant strains of microorganisms — pathogens of purulent-inflammatory diseases of the outer and middle ear.

Keywords:

phage therapy

bacteriophages

otitis

Authors:

Gurov A.V.

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia;
Sverzhevsky Research Institute of Clinical Otorhinolaryngology

ORCID: 0000-0001-9811-8397

Lapenko E.G.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology

Kryukov A.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-0149-0676

Received:

14.10.2021

Accepted:

08.02.2022

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