The article presents the results of the evaluation of the effectiveness of anti-inflammatory therapy in the perioperative period in patients with pathology of the paranasal sinuses. The study included patients (n=150) who underwent endoscopic surgery on the paranasal sinuses. All patients were divided into 3 groups. In the first (control) group (n=50) in the postoperative period, patients received standard therapy, which included antibiotic therapy and irrigation of the nasal cavity with saline. In the second comparison group (n=50), in addition to the standard treatment in the postoperative period, the preparation Erespal was added to 2 tab/day for 1 month. The third comparison group (n=50) started taking Erespal 2 tab/day 7 days before the surgery, and in the postoperative period the treatment continued in the same way as in the 2nd group (standard therapy and Erespal 2 tab/day after the operation for 1 month). The study showed that Erespal’s effectiveness after endoscopic operations on the paranasal sinuses makes it possible to accelerate the recovery period of patients, leading subjectively to the normalization of well-being and objective positive changes from the mucous membrane of the nasal cavity (decrease in edema, hyperemia, smaller changes in postoperative CT of the ONP).