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Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Kunel’skaya N.L.

N.I. Pirogov Russian National Research Medical University, Moscow, Russia, 117997;
L.I. Sverzhevsky Moscow Research and Practical Centre of Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152

Abramov V.Yu.

N.V. Sklifosovsky Research Institute of Emergency Medical Aid, Moscow Health Department, Moscow, Russia, 107045

Temnov A.A.

N.V. Sklifosovsky Research Institute of Emergency Medical Aid, Moscow Health Department, Moscow, Russia, 107045

Levina Iu.V.

Kafedra otorinolaringologii lechebnogo fakul'teta RNIMU Minzdrava RF, Moskva

Kudeeva Ia.Iu.

Kafedra otorinolaringologii lechebnogo fakul'teta RNIMU im. N.I. Pirogova, Moskva

Baybakova E.V.

GBUZ "Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii im. L.I. Sverzhevskogo", Moskva

Chugunova M.A.

GBUZ "Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii im. L.I. Sverzhevskogo", Moskva

The ototoxic action of cisplatin on the middle ear

Authors:

Krukov A.I., Kunel’skaya N.L., Abramov V.Yu., Temnov A.A., Levina Iu.V., Kudeeva Ia.Iu., Baybakova E.V., Chugunova M.A.

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Journal: Russian Bulletin of Otorhinolaryngology. 2015;80(1): 21‑24

DOI: 10.17116/otorino201580121-24

Views: 3134

Downloaded: 58

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To cite this article:

Krukov AI, Kunel’skaya NL, Abramov VYu, et al. . The ototoxic action of cisplatin on the middle ear. Russian Bulletin of Otorhinolaryngology. 2015;80(1):21‑24. (In Russ.)
https://doi.org/10.17116/otorino201580121-24

Подписка 2025 (Russian Bulletin of Otorhinolaryngology)
 
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The objective of the present study was to elucidate the mechanisms underlying the ototoxic action of cisplatin after its single administration using an experimental model (white mice). Short latency acoustically evoked potentials (SAEP) and distortion-product otoacoustic emissions (DPOAE) were recorded for the purpose. The results of the study confirm the possibility of using the proposed model for the estimation of the cisplatin-induced loss of hearing. It was shown that a single cisplatin dose causes hearing impairment in the mice within 7 days after its administration; with the maximum effect becoming apparent on day 30.

Keywords:

cisplatin
sensorineural impairment of hearing
SAEP
DPOAE

Authors:

Krukov A.I.

Sverzhevsky Moscow Scientific and Practical Othorhinolaryngology Center, Moscow

Kunel’skaya N.L.

N.I. Pirogov Russian National Research Medical University, Moscow, Russia, 117997;
L.I. Sverzhevsky Moscow Research and Practical Centre of Otorhinolaryngology, Moscow Health Department, Moscow, Russia, 117152

Abramov V.Yu.

N.V. Sklifosovsky Research Institute of Emergency Medical Aid, Moscow Health Department, Moscow, Russia, 107045

Temnov A.A.

N.V. Sklifosovsky Research Institute of Emergency Medical Aid, Moscow Health Department, Moscow, Russia, 107045

Levina Iu.V.

Kafedra otorinolaringologii lechebnogo fakul'teta RNIMU Minzdrava RF, Moskva

Kudeeva Ia.Iu.

Kafedra otorinolaringologii lechebnogo fakul'teta RNIMU im. N.I. Pirogova, Moskva

Baybakova E.V.

GBUZ "Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii im. L.I. Sverzhevskogo", Moskva

Chugunova M.A.

GBUZ "Moskovskiĭ nauchno-prakticheskiĭ tsentr otorinolaringologii im. L.I. Sverzhevskogo", Moskva

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