The use of laser Doppler flowmetry for the estimation of the influence of intranasal medications on microcirculation in nasal cavity mucosa

Svistunov A.A.; Mareev O.V.; Mareev G.O.; Bukreev I.S.

doi:https://doi.org/

Svistunov A.A.

Federal State Autonomous Educational Institution of Higher Education «I.M. Sechenov First Moscow State Medical University» of the Ministry of Healthcare of the Russia Department of Polyclinic Therapy of the Faculty of Medicine, Moscow, Russia

Mareev O.V.

Kafedra otorinolaringologii Saratovskogo gosudarstvennogo meditsinskogo universiteta im. V.I. Razumovskogo

Mareev G.O.

Kafedra otorinolaringologii Saratovskogo gosudarstvennogo meditsinskogo universiteta im. V.I. Razumovskogo

Bukreev I.S.

Kafedra otorinolaringologii Saratovskogo gosudarstvennogo meditsinskogo universiteta im. V.I. Razumovskogo

The use of laser Doppler flowmetry for the estimation of the influence of intranasal medications on microcirculation in nasal cavity mucosa

Authors:

Svistunov A.A., Mareev O.V., Mareev G.O., Bukreev I.S.

More about the authors

Journal: Russian Bulletin of Otorhinolaryngology. 2012;77(3): 34‑38

Read: 1847 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Svistunov AA, Mareev OV, Mareev GO, Bukreev IS. The use of laser Doppler flowmetry for the estimation of the influence of intranasal medications on microcirculation in nasal cavity mucosa. Russian Bulletin of Otorhinolaryngology. 2012;77(3):34‑38. (In Russ.)

Подписка 2026 Вестник оториноларингологии (Russian Bulletin of Otorhinolaryngology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Comparative analysis of the state of the microvasculature of the oral mucosa in persons with metabolic syndrome in the aspect of orthopedic dental rehabilitation. Stomatology. 2024;(6-2):15-22

Significance of Local Microcirculation Parameters in Predicting the Results of Surgical Treatment of Varicose Veins with Trophic Disorders. Journal of Venous Disorders. 2025;(1):6-14

Possibilities of applying laser-induced fluorescence spectroscopy and Doppler flowmetry methods in the case of plaque morphea. Russian Journal of Clinical Dermatology and Venereology. 2025;(5):616-624

Abstract:

Aim of the study: to investigate the influence of various intranasal medications on the microcirculatory bed in nasal cavity mucosa using the original method of laser Doppler flowmetry. Methods: this comprehensive study of the influence of intranasal medicines on nasal cavity mucosa using laser Doppler flowmetry was designed to evaluate the mucociliary clearance, breathing efficiency of the nose, and subjective symptoms of its impairment. The outcomes of a single application of intranasal medications were estimated in 90 rhinologically healthy subjects; in 15 of them, the micrcirculatory blood flow in the nasal cavity was investigated in the early postoperative period with the use of intranasal decongestants and irrigation products. Results: this study has demonstrated the relationship between the changes in the microcirculatory bed and the application of intranasal medications acting on nasal mucosa. Moreover, these agents were shown to affect intranasal mucosa and its microcirculatory bed following rhinological surgical interventions. Tachyphylaxis of the microcirculatory bed after the administration of the decongestants developed earlier than previously thought. At the came time, irrigation therapy exerted the beneficial effect on the state of the intranasal microcirculatory bed in the postoperative period.

Keywords:

intranasal medications

microcirculation in the nasal cavity

laser Doppler flowmetry

Authors:

Svistunov A.A.

Mareev O.V.

Kafedra otorinolaringologii Saratovskogo gosudarstvennogo meditsinskogo universiteta im. V.I. Razumovskogo

Mareev G.O.

Kafedra otorinolaringologii Saratovskogo gosudarstvennogo meditsinskogo universiteta im. V.I. Razumovskogo

Bukreev I.S.

Kafedra otorinolaringologii Saratovskogo gosudarstvennogo meditsinskogo universiteta im. V.I. Razumovskogo

Close metadata

References:

Mareev O.V., Mareev G.O., Fedosov I.V. Ispol'zovanie lazera dlya opredeleniya ob''emnoi skorosti krovotoka v LOR-organakh. V sb.: Novye tekhnologii v meditsine. Saratov 2001; 170-171.
Lopatin A.S., Shempelev O.A. Vliyanie razlichnykh metodov khirurgicheskogo vozdeistviya na mikrotsirkulyatsiyu slizistoi obolochki nizhnei nosovoi rakoviny po dannym lazernoi dopplerovskoi floumetrii. Vestn otorinolar 2009; 4: 31-35.
Lopatin A.S., Shempelev O.A. Lazernaya dopplerovskaya floumetriya v otsenke vliyaniya razlichnykh metodov khirurgicheskogo vozdeistviya na mikrotsirkulyatsiyu slizistoi obolochki nizhnei nosovoi rakoviny. Vestn otorinolar 2008; 5 (prilozhenie): 181-182.
Mareev O.V., Lutsevich S.I., Mareev G.O. Issledovanie mikrotsirkulyatsii slizistoi nosa s pomoshch'yu beskontaktnoi lazernoi dopplerovskoi floumetrii. Ros rinolar 2006; 2: 23-24.
Anyutin R.G., Ivkina S.V. Vozmozhnosti lazernoi dopplerovskoi floumetrii v izuchenii mikrotsirkulyatsii krovi v slizistoi obolochke polosti nosa u bol'nykh gnoinym gaimoritom. Lazer med 2005; 2: 39-42.
Anyutin R.G., Ivkina S.V., Apraksin M.A. Normativnye znacheniya parametrov mikrotsirkulyatsii krovi v slizistoi obolochke polosti nosa i rotoglotki po dannym lazernoi dopplerovskoi floumetrii. Region krovoobr i mikrotsirkulyatsiya 2008; 3: 23-27.
Vasina L.A. Vliyanie mestnykh dekongestantov, soderzhashchikh rastvor ksilometazolina, na tsiliarnuyu aktivnost' resnitchatykh kletok. Ros rinolar 2008; 3: 14-16.
Vasina L.A., Karabaeva G.S. Vliyanie preparata akva maris na tsiliarnuyu aktivnost' mertsatel'nykh kletok slizistoi obolochki nosa u bol'nykh polipoznym rinosinusitom. Kreml med 2008; 1: 13-15.
Lopatin A.S. Irrigatsionnaya terapiya v rinologii. Ros rinolar 2004; 3: 25-30.
Akulich I.I., Lopatin A.S. Otsenka effektivnosti primeneniya preparata "AkvaMaris" posle khirurgicheskikh vmeshatel'stv v polosti nosa. Ros rinolar 2003; 1: 43-46.
Luchikhin L.A., Pal'chun V.T., Belyakova L.V., Kononova N.A. Effektivnost' spreya fiziomer v posleoperatsionnyi period pri endonazal'nykh khirurgicheskikh vmeshatel'stvakh. Vestn otorinolar 2004; 3: 45-47.
Vasina L.A. Vliyanie preparata akva maris na techenie posleoperatsionnogo perioda u bol'nykh s iskrivleniem nosovoi peregorodki i khronicheskim gipertroficheskim rinitom. Ros rinol 2008; 3: 17-20.
Grudemo H., Juto J.E. Rhinostereometry and laser Doppler flowmetry in human nasal mucosa: changes in congestion andmicrocirculation during intranasal histamine challenge. J Otolaryngol Relat Spec 1997; 59: 50-56.
Grudemo H., Juto J.E. Studies of spontaneous fluctuations in congestion and nasal mucosal microcirculation and the effects of oxymetazoline using rhinostereometry and micromanipula- tor guided laser-doppler flowmetry. Am J Rhinol 1999; 13: 1-6.
Graf P., Juto J.E. Sustained use of xylometazoline nasal spray shortens the decongestive response and induces rebound swelling. Rhinology 1995; 33: 14-17.
Graf P., Juto J.E. Correlation between objective nasal mucosal swelling and estimated stuffiness during long-term use of vasoconstrictors. J Otorhinolaryngol Relat Spec 1994; 56: 3: 34-39.