Scientific legacy of Professor A.A. Kasparov. Inductor of endogenous interferon Poludan in the treatment of ocular herpes and other corneal diseases

Kasparova El.A.; Kasparova Evg.A.

doi:https://doi.org/10.17116/oftalma2023139061183

Kasparova El.A.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0003-3372-7989

Kasparova Evg.A.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-8594-2395

Scientific legacy of Professor A.A. Kasparov. Inductor of endogenous interferon Poludan in the treatment of ocular herpes and other corneal diseases

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Kasparova El.A., Kasparova Evg.A.

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Journal: Russian Annals of Ophthalmology. 2023;139(6): 183‑192

DOI: 10.17116/oftalma2023139061183

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To cite this article:

Kasparova ElA, Kasparova EvgA. Scientific legacy of Professor A.A. Kasparov. Inductor of endogenous interferon Poludan in the treatment of ocular herpes and other corneal diseases. Russian Annals of Ophthalmology. 2023;139(6):183‑192. (In Russ.)
https://doi.org/10.17116/oftalma2023139061183

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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Abstract:

This article presents a retrospective analysis of the research findings by professor A.A. Kasparov, who developed and implemented a novel approach to treating ocular herpes. The treatment system is fundamentally different from the conventional chemotherapeutic approach and revolves around non-specific immunotherapy using an endogenous interferon inducer — a biosynthetic complex of polyriboadenylic and polyribouridylic acids, known as Poludan. This approach also incorporates personalized cell therapy based on Poludan, along with herpes vaccine aimed at preventing recurrence. The regenerative and antiviral properties of this approach have proven successful in treating other corneal conditions such as adenovirus infections, early postoperative bullous keratopathy, as well as in stimulation of epithelialization after refractive surgeries (photorefractive keratectomy, phototherapeutic keratectomy).

Keywords:

interferon inducer

Poludan

PolyA:PolyU

herpes simplex keratitis

adenoviral keratoconjunctivitis

cell technologies

herpes vaccine

Authors:

Kasparova El.A.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0003-3372-7989

Kasparova Evg.A.

Krasnov Research Institute of Eye Diseases

ORCID: 0000-0001-8594-2395

Received:

28.07.2023

Accepted:

04.08.2023

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References:

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