Long-term outcomes of treating rhegmatogenous retinal detachment with macular hole using platelet-rich blood plasma

Malyugin B.E.; Shkvorchenko D.O.; Khurdaeva A.G.

doi:https://doi.org/10.17116/oftalma20231390216

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-5666-3493

Shkvorchenko D.O.

S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Khurdaeva A.G.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

ORCID: 0000-0003-3293-5487

Long-term outcomes of treating rhegmatogenous retinal detachment with macular hole using platelet-rich blood plasma

Authors:

Malyugin B.E., Shkvorchenko D.O., Khurdaeva A.G.

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Journal: Russian Annals of Ophthalmology. 2023;139(2): 6‑10

DOI: 10.17116/oftalma20231390216

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To cite this article:

Malyugin BE, Shkvorchenko DO, Khurdaeva AG. Long-term outcomes of treating rhegmatogenous retinal detachment with macular hole using platelet-rich blood plasma. Russian Annals of Ophthalmology. 2023;139(2):6‑10. (In Russ.)
https://doi.org/10.17116/oftalma20231390216

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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PURPOSE

The study analyzed the long-term outcomes of surgical treatment of rhegmatogenous retinal detachment (RRD) complicated by macular hole (MH) using platelet-rich plasma (PRP) and local staining of the internal limiting membrane (ILM).

MATERIAL AND METHODS

This prospective open-label study included 27 patients (15 females and 12 males) aged 57 to 65 (59.2±7.2) years. In all studied cases, RRD complicated by MH was determined. The best corrected visual acuity (BCVA) before surgery was 0.05±0.01 (from 0.02 to 0.08). The average MH diameter measured with OCT was 576.3±150.4 μm (409 μm to 944 μm). After vitrectomy, a perfluororganic compound (PFOC) was injected into the MH area in amount of 2—3 optic nerve head diameters to prevent the ingress of dye under the retina, then the internal limiting membrane (ILM) was stained and removed. After sequential PFOC/air replacement, PRP was injected into the macular hole site.

RESULTS AND DISCUSSION

An increase in BCVA from 0.05±0.01 to 0.09±0.03 was observed in the preoperative period one month after surgery, with a further increase to 0.35±0.11 at the maximum follow-up time (two years). The MH was blocked and a glial scar was present in all cases according to OCT data. 1—2 years after the operation, all patients showed a favorable anatomical effect according to OCT data. According to computer microperimetry data, mean macular photosensitivity was 23.8±1.3 dB two years after the surgery.

CONCLUSIONS

This study shows a favorable anatomical and functional effect in patients with RRD and MH within a 2-year follow-up. A comparative study involving a larger cohort of patients is required to clarify the indications and contraindications for the use of the studied technique.

Keywords:

rhegmatogenous retinal detachment

macular hole

platelet-rich blood plasma

Authors:

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

ORCID: 0000-0001-5666-3493

Shkvorchenko D.O.

S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Khurdaeva A.G.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

ORCID: 0000-0003-3293-5487

Received:

17.09.2021

Accepted:

09.01.2022

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