The role of CXC and CC chemokines in patients with uveal melanoma

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Myakoshina E.B.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-2087-7155

Kulikova I.G.

Helmholtz National Medical Research Center of Eye Diseases

Balatskaya N.V.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-8007-6643

Katargina L.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-4857-0374

Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-8591-428X

The role of CXC and CC chemokines in patients with uveal melanoma

Authors:

Myakoshina E.B., Kulikova I.G., Balatskaya N.V., Katargina L.A., Saakyan S.V.

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Journal: Russian Annals of Ophthalmology. 2021;137(4): 31‑37

DOI: 10.17116/oftalma202113704131

Views: 1359

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To cite this article:

Myakoshina EB, Kulikova IG, Balatskaya NV, Katargina LA, Saakyan SV. The role of CXC and CC chemokines in patients with uveal melanoma. Russian Annals of Ophthalmology. 2021;137(4):31‑37. (In Russ.)
https://doi.org/10.17116/oftalma202113704131

Подписка 2025 (Russian Annals of Ophthalmology)

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Uveal melanoma is a malignant neoplasm with high metastatic potential; its pathogenesis is currently being studied. Chemokines play a key role not only in the inflammatory response, but also in enhancing angiogenesis, tumor invasiveness, increasing proliferative potential and metastasis.

PURPOSE

To study the role of chemokines of classes CXC and CC in blood serum and tear fluid of patients with uveal melanoma.

MATERIAL AND METHODS

The study included 118 people aged 53.7±12.2 years, among them 80 patients with uveal melanoma and 38 healthy donors. Group 1 included 32 patients with small tumors, group 2 (medium-sized tumors) — 26 patients; group 3 (large tumors) was comprised of 22 patients. Chemokines of classes CC (CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL11/Eotaxin) and CXC (CXCL1/GRO-α, CXCL8/IL-8, CXCL10/IP-10, CXCL12/SDF-1α) were determined by multiplex analysis of the blood serum and tear fluid. Statistical processing: Student’s t-test, Fisher criteria, and Pierson’s chi-squared test (χ2), differences were considered significant at p<0.05.

RESULTS

Significantly increased level of chemokines with pro-inflammatory (CCL5/RANTES), proliferative (CXCL10/IP-10) and pro-angiogenic (CXCL12/SDF-1α) effects was found in the blood serum of patients with small-sized uveal melanoma in comparison with healthy donors. Concentration of all studied pro-inflammatory, proliferative, and pro-angiogenic chemokines in the lacrimal fluid was found to be significantly elevated in both the affected and the paired “healthy” eyes in all 3 groups of patients, with the maximum content seen in the large tumor group.

CONCLUSION

The obtained data indicates that early local and systemic immune imbalance can be observed in uveal melanoma, and detection of chemokines can serve as a good reason for developing targeted therapy for small uveal melanoma.

Keywords:

uveal melanoma

chemokines in blood serum and tear fluid

Authors:

Myakoshina E.B.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-2087-7155

Kulikova I.G.

Helmholtz National Medical Research Center of Eye Diseases

Balatskaya N.V.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-8007-6643

Katargina L.A.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0002-4857-0374

Saakyan S.V.

Helmholtz National Medical Research Center of Eye Diseases

ORCID: 0000-0001-8591-428X

Received:

24.06.2020

Accepted:

06.09.2020

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