The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Neroev V.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Astakhov Yu.S.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Korotkikh S.A.

Ural State Medical University

Bobykin E.V.

Ural State Medical University

Zaytseva O.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Lisochkina A.B.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Brovkina A.F.

Russian Medical Academy of Continuous Professional Education

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Gatsu M.V.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Grigoreva N.N.

N.N. Burdenko National Medical Research Center of Neurosurgery

Izmaylov A.S.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Karlova E.V.

Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky

Kovalevskaya M.A.

Voronezh State Medical Academy named after N.N. Burdenko

Nechiporenko P.A.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Panova I.E.

St. Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Ryabtseva A.A.

Moscow Regional Research and Clinical Institute (MONIKI)

Simonova S.V.

Research Institute for Healthcare and Medical Management of Moscow Healthcare Department

Tultseva S.N.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Fursova A.Zh.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Shadrichev F.E.

Saint Petersburg Regional Diabetology Center

Shishkin M.M.

Pirogov National Medical and Surgical Center

Kharlampidi M.P.

Helmholtz National Medical Research Center of Eye Diseases

Protocol of intravitreal drug delivery. Consensus of the Expert Counsil of Retina and Optic Nerve Diseases of the All-Russian Public Organasation «Association of Ophthalmologists»

Authors:

Neroev V.V., Astakhov Yu.S., Korotkikh S.A., Bobykin E.V., Zaytseva O.V., Lisochkina A.B., Brovkina A.F., Budzinskaya M.V., Gatsu M.V., Grigoreva N.N., Izmaylov A.S., Karlova E.V., Kovalevskaya M.A., Nechiporenko P.A., Panova I.E., Ryabtseva A.A., Simonova S.V., Tultseva S.N., Fursova A.Zh., Shadrichev F.E., Shishkin M.M., Kharlampidi M.P.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(6): 251‑263

DOI: 10.17116/oftalma2020136062251

Read: 10545 times

Download PDF (RU)
Contact the author
Table of contents

PROTOCOL OF INTRAVITREAL DRUG DELIVERY. CONSENSUS OF THE EXPERT COUNSIL OF RETINA AND OPTIC NERVE DISEASES OF THE ALL-RUSSIAN PUBLIC ORGANASATION «ASSOCIATION OF OPHTHALMOLOGISTS»
PROTOCOL OF INTRAVITREAL DRUG DELIVERY. CONSENSUS OF THE EXPERT COUNSIL OF RETINA AND OPTIC NERVE DISEASES OF THE ALL-RUSSIAN PUBLIC ORGANASATION «ASSOCIATION OF OPHTHALMOLOGISTS»

To cite this article:

Neroev VV, Astakhov YuS, Korotkikh SA, et al. . Protocol of intravitreal drug delivery. Consensus of the Expert Counsil of Retina and Optic Nerve Diseases of the All-Russian Public Organasation «Association of Ophthalmologists». Russian Annals of Ophthalmology. 2020;136(6):251‑263. (In Russ.)
https://doi.org/10.17116/oftalma2020136062251

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

Intravitreal drug administration is a procedure that has become widespread in modern ophthalmology. However, there is no global consensus on certain aspects of this manipulation, and practitioners feel the need for guidelines. In the Russian Federation, until now, such a document was not available. The expert council on diseases of the retina and optic nerve of All-Russian public organization «Association of Ophthalmologists», with participation of invited specialists, has studied and analyzed the existing foreign guidelines for performing intravitreal injections, as well as the regulatory framework in Russia. As a result, this Protocol was developed and approved for use in the healthcare system of the Russian Federation. The document regulates the requirements for specialists and organizations, the conditions for performing the procedure and the necessary material resources and presents an algorithm for performing intravitreal drug administration, a patient examination check-list for various conditions of the procedure, as well as parameters for evaluating and monitoring the quality of the procedure.

Keywords:

intravitreal administration/injection
protocol
requirements
procedure conditions
procedure algorithm
patient examination

Authors:

Neroev V.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Astakhov Yu.S.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Korotkikh S.A.

Ural State Medical University

Bobykin E.V.

Ural State Medical University

Zaytseva O.V.

Helmholtz National Medical Research Center of Eye Diseases;
A.I. Evdokimov Moscow State University of Medicine and Dentistry

Lisochkina A.B.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Brovkina A.F.

Russian Medical Academy of Continuous Professional Education

Budzinskaya M.V.

Krasnov Research Institute of Eye Diseases

Gatsu M.V.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Grigoreva N.N.

N.N. Burdenko National Medical Research Center of Neurosurgery

Izmaylov A.S.

Saint Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Karlova E.V.

Samara Regional Clinical Ophthalmological Hospital named after T.I. Eroshevsky

Kovalevskaya M.A.

Voronezh State Medical Academy named after N.N. Burdenko

Nechiporenko P.A.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Panova I.E.

St. Petersburg branch of S.N. Fyodorov National Medical Research Center «MNTK «Eye Microsurgery»

Ryabtseva A.A.

Moscow Regional Research and Clinical Institute (MONIKI)

Simonova S.V.

Research Institute for Healthcare and Medical Management of Moscow Healthcare Department

Tultseva S.N.

Pavlov First Saint Petersburg State Medical University (Pavlov University)

Fursova A.Zh.

Novosibirsk State Regional Clinical Hospital;
Novosibirsk State Medical University

Shadrichev F.E.

Saint Petersburg Regional Diabetology Center

Shishkin M.M.

Pirogov National Medical and Surgical Center

Kharlampidi M.P.

Helmholtz National Medical Research Center of Eye Diseases

Received:

17.07.2020

Accepted:

26.08.2020

Close metadata

References:

  1. Ramulu PY, Do DV, Corcoran KJ, Corcoran SL, Robin AL. Use of retinal procedures in medicare beneficiaries from 1997 to 2007. Arch Ophthalmol. 2010;128(10):1335-1340. https://doi.org/10.1001/archophthalmol.2010.224
  2. Peyman GA, Lad EM, Moshfeghi DM. Intravitreal injection of therapeutic agents. Retina. 2009;29(7):875-912.  https://doi. org/10.1097/IAE.0b013e3181a94f01
  3. Charles S. The Future of Surgical Retina in the Era of Medical Retina. Retin Physician. 2017;14:23-25. 
  4. Lee SS, Hughes PM, Robinson MR. Recent advances in drug delivery systems for treating ocular complications of systemic diseases. Curr Opin Ophthalmol. 2009;20(6):511-519.  https://doi. org/10.1097/ICU.0b013e328330ccb9
  5. Neroev VV. Russia’s nationwide epidemiological noninvasive study of patients with wet age-related macular degeneration. Rossiiskii oftal’mologicheskii zhurnal. 2011;4(2):4-9 (In Russ.).
  6. Okhotsimskaya TD, Zaitseva OV. Aflibercept for the therapy of retinal diseases. A review of clinical studies. Rossiiskii oftal’mologicheskii zhurnal. 2017;10(2):103-111. (In Russ.). https://doi.org/10.21516/2072-0076-2017-10-2-103-111
  7. Shadrichev FE, Grigoryeva NN, Rozhdestvenskaya ES. Antiangiogenic therapy of diabetic macular edema. Oftal’mologicheskie vedomosti. 2018;11(4):51-66. (In Russ.). https://doi.org/10.17816/OV11453-68
  8. Korotkikh SA, Bobykin EV, Nazarova NS, Melekhina EE. Long-term outcomes of anti-angiogenic therapy for macular neovascular disorders. Vestnik oftal’mologii. 2016;132(1):76-84. (In Russ.). https://doi.org/10.17116/oftalma2016132176-84
  9. Prikaz Minzdrava Rossii ot 13.10.2017 №804n (red. ot 05.03.2020) «Ob utverzhdenii nomenklatury medicinskih uslug». Accessed 12.06.2020 (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=349912&dst=1000000001&date=12.06.2020
  10. Korotkikh SA, Bobykin EV, Ekgardt VF, Malishevskaya TN, Kubareva IA, Akulevich TG, Morozova OV. Intravitreal injections in clinical practice: results of a survey of eye surgeons in the Ural federal district. Oftal’mologicheskie vedomosti. 2019;12(1):27-36. (In Russ.). https://doi.org/10.17816/OV12127-36
  11. Aiello LP, Brucker AJ, Chang S, Cunningham ET Jr, D’Amico DJ, Flynn HW Jr, Grillone LR, Hutcherson S, Liebmann JM, O’Brien TP, Scott IU, Spaide RF, Ta C, Trese MT. Evolving Guidelines for Intravitreous Injections. Retina. 2004;24(5 suppl):3-19.  https://doi.org/10.1097/00006982-200410001-00002
  12. Grzybowski A, Told R, Sacu S, Bandello F, Moisseiev E, Loewenstein A, Schmidt-Erfurth U, on behalf of the Euretina Board. 2018 Update on Intravitreal Injections: Euretina Expert Consensus Recommendations. Ophthalmologica. 2018;239(4):181-193.  https://doi.org/10.1159/000486145
  13. Avery RL, Bakri SJ, Blumenkranz MS, Brucker AJ, Cunningham ET Jr, DʼAmico DJ, Dugel PU, Flynn HW Jr, Freund KB, Haller JA, Jumper JM, Liebmann JM, McCannel CA, Mieler WF, Ta CN, Williams GA. Intravitreal injection technique and monitoring: updated guidelines of an expert panel. Retina. 2014;34(suppl 12):1-18.  https://doi.org/10.1097/IAE.0000000000000399
  14. Lai TY, Liu S, Das S, Lam DS. Intravitreal Injection — Technique and Safety. Asia Pac J Ophthalmol (Phila). 2015;4(6):321-328.  https://doi.org/10.1097/APO.0000000000000146
  15. Federal’nyj zakon ot 21.11.11 №323-FZ (red. ot 08.06.20) «Ob osnovah ohrany zdorov’ja grazhdan v Rossijskoj Federacii». Accessed 12.06.2020 (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=354521&dst=1000000001&date=12.06.2020
  16. Prikaz Minzdrava Rossii ot 12.11.12 №902n «Ob utverzhdenii Porjadka okazanija medicinskoj pomoshhi vzroslomu naseleniju pri zabolevanijah glaza, ego pridatochnogo apparata i orbity». Accessed 12.06.20 (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=139372&dst=1000000001&date=12.06.2020
  17. Prikaz Mintruda Rossii ot 05.06.17 №470n «Ob utverzhdenii professional’nogo standarta «Vrach-oftal’molog». Accessed 12.06.20. (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=219052&dst=1000000001&date=12.06.2020
  18. Kvalifikacionnye trebovanija k medicinskim i farmacevticheskim rabotnikam so srednim medicinskim i farmacevticheskim obrazovaniem. Prilozhenie k prikazu Ministerstva zdravoohranenija RF ot 10 fevralja 2016 g. №83n. Accessed 11.07.20. (In Russ.). https://ivo.garant.ru/#/document/71348254/paragraph/3:0
  19. Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 18.05.10 №58 (red. ot 10.06.16) «Ob utverzhdenii SanPiN 2.1.3.2630-10 «Sanitarno-jepidemiologicheskie trebovanija k organizacijam, osushhestvljajushhim medicinskuju dejatel’nost’» (vmeste s «SanPiN 2.1.3.2630-10. Sanitarno-jepidemiologicheskie pravila i normativy...»). Accessed 12.06.20. (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=200185&dst=23%2C1&date=12.06.2020
  20. Nacional’nyj standart RF GOST R 57525-2017 «Kliniko-jekonomicheskie issledovanija. Obshhie trebovanija» (Utverzhdjon i vvedjon v dejstvie prikazom Federal’nogo agentstva po tehnicheskomu regulirovaniju i metrologii ot 6 ijulja 2017 g. №655-st). Accessed 11.07.20. (In Russ.). https://docs.cntd.ru/document/1200146142
  21. Prikaz Minzdrava SSSR ot 4 oktjabrja 1980 g. №1030 «Ob utverzhdenii form pervichnoj medicinskoj dokumentacii uchrezhdenij zdravoohranenija» (s izmenenijami na 31 dekabrja 2002 g.). Accessed 11.07.20. (In Russ.). https://docs.cntd.ru/document/9042149
  22. Prikaz Minzdravsocrazvitija RF ot 29.12.08 №786n (red. ot 07.12.09) «O porjadke formirovanija i utverzhdenii gosudarstvennogo zadanija na okazanie v 2009 g. vysokotehnologichnoj medicinskoj pomoshhi grazhdanam Rossijskoj Federacii za schet assignovanij federal’nogo bjudzheta» (vmeste s «Porjadkom napravlenija grazhdan v medicinskie uchrezhdenija dlja okazanija vysokotehnologichnoj medicinskoj pomoshhi v ramkah gosudarstvennogo zadanija na okazanie v 2009 g. vysokotehnologichnoj medicinskoj pomoshhi grazhdanam Rossijskoj Federacii za schet assignovanij federal’nogo bjudzheta»). Accessed 12.06.20. (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=97002&dst=730&date=12.06.2020
  23. Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 28.02.08 №14 «Ob utverzhdenii sanitarno-jepidemiologicheskih pravil SP 3.1.1.2341-08» (vmeste s «SP 3.1.1.2341-08. Profilaktika virusnogo gepatita B. Sanitarno-jepidemiologicheskie pravila»). Accessed 12.06.20. (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=75983&dst=1000000001&date=12.06.2020
  24. Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 22.10.13 №58 «Ob utverzhdenii sanitarno-jepidemiologicheskih pravil SP 3.1.3112-13 «Profilaktika virusnogo gepatita C» (vmeste s «SP 3.1.3112-13. Sanitarno-jepidemiologicheskie pravila...»). Accessed 12.06.20. (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=160657&dst=100005&date=12.06.2020
  25. Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 11.01.11 №1 (red. ot 21.07.16) «Ob utverzhdenii SP 3.1.5.2826-10 «Profilaktika VICh-infekcii» (vmeste s «SP 3.1.5.2826-10. Sanitarno-jepidemiologicheskie pravila...»). Accessed 12.06.20. (In Russ.). https://login.consultant.ru/link/?req=doc&base=RZR&n=206291&dst=100004%2C1&date=12.06.2020
  26. Standartizacija v zdravoohranenii. Uchebnoe posobie. Sost. Ignatova O.A., Men’shikova L.I., D’jachkova M.G. Arhangel’sk: Izd-vo Severnogo gosudarstvennogo medicinskogo universiteta; 2018. (In Russ.).
  27. GOST R 52623.4—2015 Tehnologii vypolnenija prostyh medicinskih uslug invazivnyh vmeshatel’stv. Utverzhdjon i vvedjon v dejstvie Prikazom Federal’nogo agentstva po tehnicheskomu regulirovaniju i metrologii Rossijskoj Federacii ot 31 marta 2015 g. №200-st. Accessed 11.07.20. (In Russ.). https://docs.cntd.ru/document/1200119182
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.