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Nevinitsyna T.A.
FGBU "NII glaznykh bolezneĭ"
Sheremet N.L.
FGBU "NII glaznykh bolezneĭ" RAMN
Molecular mechanisms and pathogenetic treatment of mitochondrial optic neuropathies
Journal: Russian Annals of Ophthalmology. 2016;132(1): 91‑96
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To cite this article:
Nevinitsyna TA, Sheremet NL. Molecular mechanisms and pathogenetic treatment of mitochondrial optic neuropathies. Russian Annals of Ophthalmology.
2016;132(1):91‑96. (In Russ.)
https://doi.org/10.17116/oftalma2016132191-96
The article presents a review of literature on inherited optic neuropathies (ION), namely, Leber`s hereditary optic neuropathy and autosomal dominant optic neuropathy. Their molecular genetic characteristics and pathogenetic mechanisms such as mitochondrial respiratory chain deficiency, oxidative stress, mitochondrial dynamics, and biogenesis are covered. Prospects of ION treatment are described.
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Authors:
Nevinitsyna T.A.
FGBU "NII glaznykh bolezneĭ"
Sheremet N.L.
FGBU "NII glaznykh bolezneĭ" RAMN
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