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Shevchenko A.V.

Research Institute — Ochapovsky Regional Clinical Hospital of Healthcare Ministry of the Krasnodar Territory, Department of Traumatology and Orthopedics №1, Krasnodar, Russia

Prokof’ev V.F.

Research Institute of Clinical and Experimental Lymрhology, 2 Timakova St., Novosibirsk, Russian Federation, 630060

Korolev M.A.

FGBU "NII klinicheskoĭ i éksperimental'noĭ limfologii" SO RAMN, Novosibirsk

Banshchikova N.E.

Research Institute of Clinical and Experimental Lymрhology, Novosibirsk, Russia

Konenkov V.I.

NII klinicheskoĭ i éksperimental'noĭ limfologii Sibirskogo otdeleniia RAMN, Novosibirsk

Polymorphism in the regulatory regions –С2578A and +C936T of the vascular endothelial growth factor (VEGF-A) gene in Russian women with rheumatoid arthritis

Authors:

Shevchenko A.V., Prokof’ev V.F., Korolev M.A., Banshchikova N.E., Konenkov V.I.

More about the authors

Journal: Therapeutic Archive. 2017;89(5): 60‑64

DOI: 10.17116/terarkh201789560-64

Read: 2671 times

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Table of contents

POLYMORPHISM IN THE REGULATORY REGIONS –С2578A AND +C936T OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF-A) GENE IN RUSSIAN WOMEN WITH RHEUMATOID ARTHRITIS
POLYMORPHISM IN THE REGULATORY REGIONS –С2578A AND +C936T OF THE VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF-A) GENE IN RUSSIAN WOMEN WITH RHEUMATOID ARTHRITIS

To cite this article:

Shevchenko AV, Prokof’ev VF, Korolev MA, Banshchikova NE, Konenkov VI. Polymorphism in the regulatory regions –С2578A and +C936T of the vascular endothelial growth factor (VEGF-A) gene in Russian women with rheumatoid arthritis. Therapeutic Archive. 2017;89(5):60‑64. (In Russ.)
https://doi.org/10.17116/terarkh201789560-64

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Abstract:

Aim. To analyze polymorphism in the regulatory regions of the vascular endothelial growth factor (VEGF) gene in female patients with rheumatoid arthritis (RA). Subjects and methods. The investigation enrolled 257 female patients with RA. A control group consisted of 297 women without chronic diseases. The investigators examined the single-nucleotide polymorphism of VEGF-А2578С in the promoter region (rs699947) and that of VEGF+С936Т 3 in the retranslated region (rs3025039) of the gene. Genotyping was performed by restriction fragment length polymorphism analysis. Results. There was an increase in the frequency of VEGF+936 CT and a reduction in that of the VEGF+936СС genotypes in the seronegative patients as compared to the healthy women. The VEGF+936СС genotype frequency was higher in the patients with seropositive RA than in the subgroup of seronegative patients. The frequency of the VEGF-2578СС genotype was increased in the patients with RA and rheumatoid nodules, as compared to the healthy women. Conclusion. The data presented suggest that the presence of certain VEGF gene variants located in the regulatory regions may reflect the nature of immunopathological mechanisms in RA.

Keywords:

rheumatoid arthritis
gene polymorphism
vascular endothelial growth factor (VEGF)

Authors:

Shevchenko A.V.

Research Institute — Ochapovsky Regional Clinical Hospital of Healthcare Ministry of the Krasnodar Territory, Department of Traumatology and Orthopedics №1, Krasnodar, Russia

Prokof’ev V.F.

Research Institute of Clinical and Experimental Lymрhology, 2 Timakova St., Novosibirsk, Russian Federation, 630060

Korolev M.A.

FGBU "NII klinicheskoĭ i éksperimental'noĭ limfologii" SO RAMN, Novosibirsk

Banshchikova N.E.

Research Institute of Clinical and Experimental Lymрhology, Novosibirsk, Russia

Konenkov V.I.

NII klinicheskoĭ i éksperimental'noĭ limfologii Sibirskogo otdeleniia RAMN, Novosibirsk

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