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Kvachakhiya L.L.

Kursk State Medical University

Shormanov V.K.

Kursk State Medical University of Ministry of Health of Russia

Lercanidipine distribution in warm-blooded animals

Authors:

Kvachakhiya L.L., Shormanov V.K.

More about the authors

Journal: Forensic Medical Expertise. 2023;66(5): 47‑52

DOI: 10.17116/sudmed20236605147

Read: 2391 times

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Table of contents

LERCANIDIPINE DISTRIBUTION IN WARM-BLOODED ANIMALS
LERCANIDIPINE DISTRIBUTION IN WARM-BLOODED ANIMALS

To cite this article:

Kvachakhiya LL, Shormanov VK. Lercanidipine distribution in warm-blooded animals. Forensic Medical Expertise. 2023;66(5):47‑52. (In Russ.)
https://doi.org/10.17116/sudmed20236605147

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

THE AIM OF THE STUDY

Is to investigate the lercadipine distribution in warm-blooded animals (rats). The experimental study used rats of Wistar race. TLC, GC-MS and UV-spectrophotometry methods were used for physical and chemical analysis. Semilethal (890 mg/kg) dose of lercadipine, previously suspended in water, was injected into stomach of laboratory animals. Examined substance was isolated from the thick tissues and animals’ blood by acetone, cleaned with a change of solvent and macrocolumn chromatography using 30 µm «Silasorb S-18» sorbent and acetonitrile-water (8:2) polar eluent. The analyte was identified by chromatographic behavior in the thin sorbent layer, retention time and set of positive ions in its mass spectrum, as well as by UV-spectrum. The analyte was determined quantitatively in bioactive matrix using UV-spectrophotometry. The methods were validated by criteria of linearity, selectivity, accuracy, precision, detection limits and quantitative determination. The main content of lercanidipine (mg/100 g) was determined in the stomach content (198.183±29.541), the stomach (195.312±21.579), the small intestine (47.096±3.947), the spleen (38.952±3.532) and the liver (26.211±2.232).

Keywords:

lercanidipine
distribution in vivo
warm-blooded animals
chemical toxicology screening

Authors:

Kvachakhiya L.L.

Kursk State Medical University

Shormanov V.K.

Kursk State Medical University of Ministry of Health of Russia

Received:

08.06.2022

Accepted:

28.06.2022

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References:

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  22. Receiver 08.06.2022 
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