The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Shchegolev A.I.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Tumanova U.N.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Savva O.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov;
Bureau of Forensic Medicine named after D.I. Mastbaum

Characteristics of histochemical, molecular genetic and radiation-induced liver changes depending on the postmortem interval

Authors:

Shchegolev A.I., Tumanova U.N., Savva O.V.

More about the authors

Journal: Forensic Medical Expertise. 2023;66(3): 59‑63

DOI: 10.17116/sudmed20236603159

Read: 1522 times

Download PDF (RU)
Contact the author
Table of contents

CHARACTERISTICS OF HISTOCHEMICAL, MOLECULAR GENETIC AND RADIATION-INDUCED LIVER CHANGES DEPENDING ON THE POSTMORTEM INTERVAL
CHARACTERISTICS OF HISTOCHEMICAL, MOLECULAR GENETIC AND RADIATION-INDUCED LIVER CHANGES DEPENDING ON THE POSTMORTEM INTERVAL

To cite this article:

Shchegolev AI, Tumanova UN, Savva OV. Characteristics of histochemical, molecular genetic and radiation-induced liver changes depending on the postmortem interval. Forensic Medical Expertise. 2023;66(3):59‑63. (In Russ.)
https://doi.org/10.17116/sudmed20236603159

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Characteristics of postmortem changes in the brain. Fore­nsic Medi­cal Expe­rtise. 2024;(6):56-61
Mathematical programming in asse­ssment of the postmortem inte­rval under conditions of linearly varying exte­rnal temperature. Fore­nsic Medi­cal Expe­rtise. 2025;(4):34-39
Accountance of instrumental error in measuring corpse’s temperature when dete­rmining postmortem inte­rval (a case from practice). Fore­nsic Medi­cal Expe­rtise. 2025;(5):53-57
Textbook outcome for liver rese­ction. Survey of respondents in national centers. Piro­gov Russian Journal of Surgery. 2025;(4):5-11
Liver invo­lvement in Gaucher disease in children: A lite­rature review and clinical obse­rvations. Russian Journal of Evidence-Based Gastroenterology. 2025;(2):78-93
Abstract:

The aim of this study is to analyze literature data on postmortem changes in the liver and their use in determination of postmortem interval. Biological death expectedly causes the development of postmortem disorders not only in the liver structure, but also changes in its biochemical and histochemical parameters. Literature data about changes of histochemical, immunohistochemical and biomolecular characteristics of liver tissue, as well as bacterial migration to the liver depending on the duration of postmortem period, are presented. The effectiveness of radiology for visualization of postmortem changes and, accordingly, for determining the postmortem interval is noted.

Keywords:

liver
postmortem changes
autolysis
postmortem interval

Authors:

Shchegolev A.I.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Tumanova U.N.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Savva O.V.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov;
Bureau of Forensic Medicine named after D.I. Mastbaum

Received:

01.06.2022

Accepted:

23.06.2022

Close metadata

References:

  1. Shchegolev AI, Tumanova UN, Savva OV. Characteristics of liver changes depending on the time after death. Sudebno-meditsinskaya ekspertiza. 2023;66(1):50-54. (In Russ.). https://doi.org/10.17116/sudmed20236601150
  2. Lesnikova I, Schreckenbach MN, Kristensen MP, Papanikolaou LL, Hamilton-Dutoit S. Usability of immunohistochemistry in forensic samples with varying decomposition. Am J Forensic Med Pathol. 2018;39(3):185-191.  https://doi.org/10.1097/PAF.0000000000000408
  3. Madea B, Henssge C, Reibe S, Tsokos M, Kernbach-Wighton G. Postmortem changes and time since death. In. Handbook of forensic medicine. UK: Wiley-Blackwell; 2014.
  4. Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35(4):495-516.  https://doi.org/10.1080/01926230701320337
  5. Jin Z, El-Deiry WS. Overview of cell death signaling pathways. Cancer Biol Ther. 2005;4(2):139-163.  https://doi.org/10.4161/cbt.4.2.1508
  6. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001;104(4):487-501.  https://doi.org/10.1016/s0092-8674(01)00237-9
  7. Noshy PA. Postmortem expression of apoptosis-related genes in the liver of mice and their use for estimation of the time of death. Int J Legal Med. 2021;135(2):539-545.  https://doi.org/10.1007/s00414-020-02419-5
  8. Halawa AA, Marghani BH. Thanatotranscriptome study on particular hepatic genes and their correlation with postmortem interval in the presence or absence of postmortem heat stress. Alexandria J Vet Sci. 2018;57(2):13-20. 
  9. Javan GT, Can I, Finley SJ, Soni S. The apoptotic thanatotranscriptome associated with the liver of cadavers. Forensic Sci Med Pathol. 2015;11(4):509-516.  https://doi.org/10.1007/s12024-015-9704-6
  10. Kim JY, Kim Y, Cha HK, Lim HY, Kim H, Chung S, Hwang JJ, Park SH, Son GH. Cell death-associated ribosomal RNA cleavage in postmortem tissues and its forensic applications. Mol Cells. 2017;40(6):410-417.  https://doi.org/10.14348/molcells.2017.0039
  11. Finger JM, Mercer JF, Cotton RG, Danks DM. Stability of protein and mRNA in human postmortem liver — analysis by two-dimensional gel electrophoresis. Clin Chim Acta. 1987;170(2-3):209-218.  https://doi.org/10.1016/0009-8981(87)90130-6
  12. Lv YH, Ma JL, Pan H, Zeng Y, Tao L, Zhang H, Li WC, Ma KJ, Chen L. Estimation of the human postmortem interval using an established rat mathematical model and multi-RNA markers. Forensic Sci Med Pathol. 2017;13(1):20-27.  https://doi.org/10.1007/s12024-016-9827-4
  13. Khalikov AA, Kildyushov EM, Kuznetsov KO, Iskuzhina LR, Rakhmatullina GR. Use of microrna to estimate time science death: review. Sudebnaya meditsina. 2021;3:132-138. (In Russ.).
  14. Tu C, Du T, Shao C, Liu Z, Li L, Shen Y. Evaluating the potential of housekeeping genes, rRNAs, snRNAs, microRNAs and circRNAs as reference genes for the estimation of PMI. Forensic Sci Med Pathol. 2018;14(2):194-201.  https://doi.org/10.1007/s12024-018-9973-y
  15. Mao S, Fu G, Seese RR, Wang ZY. Estimation of PMI depends on the changes in ATP and its degradation products. Leg Med (Tokyo). 2013;15(5):235-238.  https://doi.org/10.1016/j.legalmed.2013.03.004
  16. Miura M, Naka T, Miyaishi S. Postmortem changes in myoglobin content in organs. Acta Med Okayama. 2011;65(4):225-230.  https://doi.org/10.18926/AMO/46847
  17. Gos T, Raszeja S. Postmortem activity of lactate and malate dehydrogenase in human liver in relation to time after death. Int J Legal Med. 1993;106(1):25-29.  https://doi.org/10.1007/BF01225020
  18. Sakurada K, Kobayashi M, Iwase H, Yoshino M, Mukoyama H, Takatori T, Yoshida K. Production of gamma-hydroxybutyric acid in postmortem liver increases with time after death. Toxicol Lett. 2002;129(3):207-217.  https://doi.org/10.1016/s0378-4274(02)00019-x
  19. Paltian JJ, da Fonseca CAR, Pinz MP, Luchese C, Antunes Wilhelm E. Post-mortem interval estimative through determination of catalase and Δ-aminolevulinate dehydratase activities in hepatic, renal, skeletal muscle and cerebral tissues of Swiss mice. Biomarkers. 2019;24(5):478-483.  https://doi.org/10.1080/1354750X.2019.1619837
  20. da Fonseca CAR, Paltian J, Dos Reis AS, Bortolatto CF, Wilhelm EA, Luchese C. Na+/K+-ATPase, acetylcholinesterase and glutathione S-transferase activities as new markers of postmortem interval in Swiss mice. Leg Med (Tokyo). 2019;36:67-72.  https://doi.org/10.1016/j.legalmed.2018.11.003
  21. Permyakov NK. Patologiya reanimatsii i intensivnoy terapii. M.: Meditsina; 1985. (In Russ.).
  22. Mishnev OD, Shchegolev AI. Histophotometric characteristics of structural-metabolic heterogeneity of hepatocytes in acute hemorrhage and pulmonary artery thromboembolism. Biull Eksp Biol Med. 1992;113(4):433-435. 
  23. Lysova NL, Gurevich LE, Trusov OA, Shchegolev AI, Mishnev OD. Immunohistochemical characteristics of the liver in patients with peritonitis (early autopsy). Bull Exp Biol Med. 2001;132(5):1125-1129. https://doi.org/10.1023/a:1017993214196
  24. Mishnev OD, Shchegolev AI, Salakhov IM. Comparative morphofunctional study of liver acini in peritonitis of different origin. Bull Exp Biol Med. 1998;126(4):1056-1058. https://doi.org/10.1007/BF02447320
  25. Huang P, Tian W, Tuo Y, Wang Z, Yang G. Estimation of postmortem interval in rat liver and spleen using fourier transform infrared spectroscopy. Spectroscopy Letters: An Intern. J Rapid Commun. 2009;42(2):108-116.  https://doi.org/10.1080/00387010802375362
  26. Huang P, Zou D, Li S, Xu C, Luo Y, Sun Q, Deng K, Wang Z, Wang Z, Chen Y. Characterization of the postmortem interval by infrared microscopy. Anal Lett. 2015:49(2):290-298.  https://doi.org/10.1080/00032719.2015.1070162
  27. Mourino-Alvarez L, Iloro I, de la Cuesta F, Azkargorta M, Sastre-Oliva T, Escobes I, Lopez-Almodovar LF, Sanchez PL, Urreta H, Fernandez-Aviles F, Pinto A, Padial LR, Akerström F, Elortza F, Barderas MG. MALDI-Imaging mass spectrometry: a step forward in the anatomopathological characterization of stenotic aortic valve tissue. Sci Rep. 2016;6:27106. https://doi.org/10.1038/srep27106
  28. Li C, Li Z, Tuo Y, Ma D, Shi Y, Zhang Q, Zhuo X, Deng K, Chen Y, Wang Z, Huang P. MALDI-TOF MS as a novel tool for the estimation of postmortem interval in liver tissue samples. Sci Rep. 2017;7(1):4887. https://doi.org/10.1038/s41598-017-05216-0
  29. Wilson SJ, Wilson ML, Reller LB. Diagnostic utility of postmortem blood cultures. Arch Pathol Lab Med. 1993;117(10):986-988. 
  30. Carpenter HM, Wilkins RM. Autopsy bacteriology: review of 2,033 cases. Arch Pathol. 1964;77:73-81. 
  31. Morris JA, Harrison LM, Partridge SM. Postmortem bacteriology: a re-evaluation. J Clin Pathol. 2006;59(1):1-9.  https://doi.org/10.1136/jcp.2005.028183
  32. Weber MA, Hartley JC, Brooke I, Lock PE, Klein NJ, Malone M, Sebire NJ. Post-mortem interval and bacteriological culture yield in sudden unexpected death in infancy (SUDI). Forensic Sci Int. 2010;198(1-3):121-125.  https://doi.org/10.1016/j.forsciint.2010.02.002
  33. Tuomisto S, Karhunen PJ, Vuento R, Aittoniemi J, Pessi T. Evaluation of postmortem bacterial migration using culturing and real-time quantitative PCR. J Forensic Sci. 2013;58(4):910-916.  https://doi.org/10.1111/1556-4029.12124
  34. Dell’Annunziata F, Martora F, Pepa MED, Folliero V, Luongo L, Bocelli S, Guida F, Mascolo P, Campobasso CP, Maione S, Franci G, Galdiero M. Postmortem interval assessment by MALDI-TOF mass spectrometry analysis in murine cadavers. J Appl Microbiol. 2022;132(1):707-714.  https://doi.org/10.1111/jam.15210
  35. Tumanova UN. Formation and development of postmortem radiological research in the world and in Russia. REJR. 2020;10(4):250-263. (In Russ.). https://doi.org/10.21569/2222-7415-2020-10-4-250-263
  36. Tumanova UN, Shchegolev AI, Kovalev AV. Organization of postmortem radiological examination in the structure of pathological departments and forensic bureaus. Sudebno-meditsinskaya ekspertiza. 2021;1:57-63. (In Russ.). https://doi.org/10.17116/sudmed20216401157
  37. Fetisov VA, Kuprina TA, Sinitsyn VE, Dubrova SE, Filimonov BA. The foreign experience with the application of the modern radiodiagnostic methods for the estimation of prescription of death coming and time of infliction of injury. Sudebno-meditsinskaya ekspertiza. 2016;2:47-54. (In Russ.). https://doi.org/10.17116/sudmed201659247-54
  38. Tumanova UN, Shchegolev AI. Radio-visualization of non-specific postmortem changes in the cardiovascular system. Sudebno-meditsinskaya ekspertiza. 2016;5:59-63. (In Russ.). https://doi.org/10.17116/sudmed2016595559-63
  39. Jackowski C, Thali M, Aghayev E, Yen K, Sonnenschein M, Zwygart K, Dirnhofer R, Vock P. Postmortem imaging of blood and its characteristics using MSCT and MRI. Int J Legal Med. 2006;120(4):233-240.  https://doi.org/10.1007/s00414-005-0023-4
  40. Tumanova UN, Bychenko VG, Serova NS, Shchegolev AI. Postmortem MRI Characterization of Cadaveric Hypostases in Deceased Newborns. Bull Exp Biol Med. 2021;170(3):371-377.  https://doi.org/10.1007/s10517-021-05070-1
  41. Krupnov NM, Tumanova UN, Shchegolev AI, Bychenko VG, Vanyukov VN, Uslontsev DN, Savva OV. Method for determining prescription of death coming. Patent RF No. 2746665. 2021. Byul. No. 11. (In Russ.).
  42. Shelmerdine SC, Main C, Hutchinson JC, Langan D, Sebire NJ, Arthurs OJ. The use of whole body diffusion-weighted post-mortem magnetic resonance imaging in timing of perinatal deaths. Int J Legal Med. 2018;132(6):1735-1741. https://doi.org/10.1007/s00414-018-1906-5
  43. Shiotani S, Kobayashi T, Hayakawa H, Homma K, Sakahara H. Hepatic relaxation times from postmortem MR imaging of adult humans. Magn Reson Med Sci. 2016;15(3):281-287.  https://doi.org/10.2463/mrms.mp.2015-0086
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.