Potential for the use of cards for sampling and transportation of biological material during forensic chemical and toxicological examinations

Barseghyan S.S.; Kalekin R.A.; Volkova A.A.; Astashkina O.G.

doi:https://doi.org/10.17116/sudmed20226504151

Barseghyan S.S.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-9882-2330

Kalekin R.A.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-4989-3511

Volkova A.A.

Russian Center of Forensic Medical Examination

ORCID: 0000-0002-5419-1418

Astashkina O.G.

Russian Center of Forensic Medical Expertise;
Bureau of Forensic Medicine of Moscow Healthcare Department

Potential for the use of cards for sampling and transportation of biological material during forensic chemical and toxicological examinations

Authors:

Barseghyan S.S., Kalekin R.A., Volkova A.A., Astashkina O.G.

More about the authors

Journal: Forensic Medical Expertise. 2022;65(4): 51‑56

DOI: 10.17116/sudmed20226504151

Read: 1391 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Barseghyan SS, Kalekin RA, Volkova AA, Astashkina OG. Potential for the use of cards for sampling and transportation of biological material during forensic chemical and toxicological examinations. Forensic Medical Expertise. 2022;65(4):51‑56. (In Russ.)
https://doi.org/10.17116/sudmed20226504151

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)

Использование инфографики авторами научных работ

Close metadata

Abstract:

The objective of the study is to evaluate the potential for the use of cards for sampling and transportation of biological material during forensic chemical and toxicological examinations by the example of a biological sample, urine containing zopiclone. Two methods of sample preparation were compared. The use of cards for the collection and transportation of biological material, such as urine, followed by high-resolution high-performance liquid chromatography-mass spectrometry (HPLC-MS) for the identification of zopiclone metabolites was shown to be beneficial in forensic chemical and toxicological examination. The validation evaluation of the proposed sample preparation and identification method met the acceptance criteria.

Keywords:

urine

zopiclone

forensic chemistry

biological material collection and transportation card

high performance liquid chromatography

Authors:

Barseghyan S.S.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-9882-2330

Kalekin R.A.

Russian Center of Forensic Medical Examination;
Peoples’ Friendship University of Russia

ORCID: 0000-0002-4989-3511

Volkova A.A.

Russian Center of Forensic Medical Examination

ORCID: 0000-0002-5419-1418

Astashkina O.G.

Russian Center of Forensic Medical Expertise;
Bureau of Forensic Medicine of Moscow Healthcare Department

Received:

22.02.2022

Accepted:

17.03.2022

Close metadata

References:

Vladimirov VYu, Kovalev AV, Minaeva PV, Samokhodskaya OV. Overdose deaths from narcotic drugs and psychotropic substances in Russia (an analysis of materials for the period 2003 to 2018). Sudebno-meditsinskaya ekspertiza. 2019;62(5):4-8. (In Russ.). https://doi.org/10.17116/sudmed2019620514
Salomatin EM, Kalekin RA. Forensic chemistry as a pharmaceutical discipline. Sudebno-meditsinskaya ekspertiza. 2014;57(4):61-64. (In Russ.).
Instruktsiya po meditsinskomu primeneniyu lekarstvennogo preparata Imovan P№015904/01-290920. (In Russ.).
Porseva NYu, Dvorskaya ON. Legal aspects of the turnover of sleeping pills that can cause drug dependence. Sovremenny’e problemy’ nauki i obrazovaniya. 2015;3:242. (In Russ.).
Orlova AM, Kalekin RA, Volkova AA, Nevmyatova SR, Polushkina NV. Detection of clobazam in urine by thin-layer chromatography. Vestnik Voronezhskogo gosudarstvennogo universiteta. Seriya: Khimiya. Biologiya. Farmatsiya. 2021;3:106-113. (In Russ.).
Kalyekin RA, Pavlova AZ, Orlova AM, Bulygina IE. K voprosu ustanovleniya fakta otravleniya psikhotropnymi i silnodejstvuyushhimi veshchestvami v biologicheskikh obʹektakh neinvazivnogo sposoba otbora. V sb.: Dekabrʹskie chteniya po sudebnoy meditsine v RUDN: aktualʹnye voprosy sudebnoy meditsiny i obshchey patologii. Sbornik materialov Vserossiyskoy nauchno-prakticheskoy konferentsii s mezhdunarodny’m uchastiem. Rossijskiy universitet druzhby narodov. 2019;89-93. (In Russ.).
Helfer AG, Michely JA, Weber AA, Meyer MR, Maurer HH. Liquid chromatography-high resolution-tandem mass spectrometry using Orbitrap technology for comprehensive screening to detect drugs and their metabolites in blood plasma. Analytica Chimica Acta. 2017;965:83-95. https://doi.org/10.1016/j.aca.2017.03.002
Helfer AG, Michely JA, Weber AA, Meyer MR, Maurer HH. Orbitrap technology for comprehensive metabolite-based liquid chromatographic-high resolution-tandem mass spectrometric urine drug screening — exempliﬁed for cardiovascular drugs. Analytica Chimica Acta. 2015;891:221-233.
Savchuk SA, Shestakova KM, Rizvanova LN, Burmykin DA, Ovcharov MV, Mesonzhnik NV, Appolonova SA. Fast HPLC MS/MS is a screening technique for the determination of illicit drugs in human urine, including new psychoactive substances, as well as their metabolites. Sudebno-meditsinskaya ekspertiza. 2020;63(2):32-40. (In Russ.). https://doi.org/10.17116/sudmed20206302132
Pavlova AZ, Kalyekin RA, Orlova AM, Larev ZV. Vozmozhnosti laboratornoy diagnostiki otravleniy dlya sudebno-meditsinskikh i klinicheskikh tseley. V sb.: Trezvost’ kak sotsialniy faktor razvitiya obshhestva. Sbornik statej Vserossiyskoy nauchno-prakticheskoy konferentsii. Chuvashskiy gosudarstvenniy universitet im. I.N. Ul’yanova. 2018;168-175. (In Russ.).
Kalyekin RA, Salomatin EM, Kalyekina VA, Volkova AA. Laboratory diagnostics of poisoning by neuroleptics with benzamide derivatives in narcology: opportunities and problems. Narkologiya. 2008;4(76):33-37. (In Russ.).
Salomatin EM, Kalyekin RA, Orlova AM, Valueva MI. Features and prospects of ptomain research for the purposes of forensic chemical analysis. Sudebno-meditsinskaya ekspertiza. 2015;58(6):49-52. (In Russ.). https://doi.org/10.17116/sudmed201558649-52
Kalyekin RA. Isolation of neuroleptics of benzamide derivatives from saliva. Narkologiya. 2013;2(134);72-73. (In Russ.).
Kalyekin RA, Lazaryan DS. Development of a technique for isolating thiapride from saliva for chemical and toxicological analysis. Nauchnoe obozrenie. 2005;6:18-20. (In Russ.).
Kalyekin RA, Lazaryan DS. Isolation of tiapride from cadaveric material during forensic chemical examination. Akademicheskiy zhurnal Zapadnoy Sibiri. 2005;4:34-35. (In Russ.).
Barsegyan SS, Salomatin EM, Pleteneva TV, Maksimova TV, Dolinkin AO. Metodicheskie rekomendatsii po validatsii analiticheskikh metodik, ispol′zuemykh v sudebno-khimicheskom i khimiko-toksikologicheskom analize biologicheskogo materiala. Rekomendovano k izdaniyu Uchenym sovetom FGBU «RCZSME’» Minzdrava Rossii (protokol №3 ot 19 iyunya 2014 goda). M. 2014. (In Russ.).