The article analyzes and systematizes materials on the establishment and development of forensic medicine in Uzbekistan. It was noted that until the 1960—1970s, no independent forensic medical examinations were conducted in Turkestan, Uzbekistan in particular. The formation of scientific forensic medicine began with the establishment of the Uzbek National University (1918) with the Faculty of Medicine, where forensic medicine was taught. In the 1940—1950s, forensic medical examination bureaus (FME) were established in the regional centers of Uzbekistan. At present, the FME service includes the Republican Scientific and Practical Center for FME with its regional branches in Karakalpakstan and other regions, the departments of forensic medicine, and medical law of medical universities. The regulations and standards for all types of forensic examinations were fully updated in line with the Constitution of the Republic of Uzbekistan and the Forensic Science Act.