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Kuznetsova V.S.

Research Centre for Medical Genetics;
Central Research Institute of Dentistry and Maxillofacial Surgery

Vasilyev A.V.

Central Research Institute of Dentistry and Maxillofacial Surgery;
Research Centre for Medical Genetics

Bukharova T.B.

Research Centre for Medical Genetics

Nedorubova I.A.

Research Centre for Medical Genetics

Goldshtein D.V.

Bochkov Medical and Genetic Research Center

Kulakov A.A.

Central Research Institute of Dentistry and Maxillofacial Surgery

Advantages and disadvantages of bone graft materials activated by BMP-2 and constructs carrying its gene

Authors:

Kuznetsova V.S., Vasilyev A.V., Bukharova T.B., Nedorubova I.A., Goldshtein D.V., Kulakov A.A.

More about the authors

Journal: Stomatology. 2023;102(4): 76‑80

DOI: 10.17116/stomat202310204176

Read: 1465 times

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Table of contents

ADVANTAGES AND DISADVANTAGES OF BONE GRAFT MATERIALS ACTIVATED BY BMP-2 AND CONSTRUCTS CARRYING ITS GENE
ADVANTAGES AND DISADVANTAGES OF BONE GRAFT MATERIALS ACTIVATED BY BMP-2 AND CONSTRUCTS CARRYING ITS GENE

To cite this article:

Kuznetsova VS, Vasilyev AV, Bukharova TB, Nedorubova IA, Goldshtein DV, Kulakov AA. Advantages and disadvantages of bone graft materials activated by BMP-2 and constructs carrying its gene. Stomatology. 2023;102(4):76‑80. (In Russ.)
https://doi.org/10.17116/stomat202310204176

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

In the review gene constructs and proteins used to impart osteoinductive properties to bone graft materials are compared. On the basis of clinical and experimental data the experience and prospects of their application in maxillofacial surgery and dentistry are described. Information about complications associated with the use of bone morphogenetic protein-2 (BMP-2) and vectors carrying its gene is provided.

Keywords:

gene-activated materials
bone morphogenetic proteins
BMP-2
osteogenesis

Authors:

Kuznetsova V.S.

Research Centre for Medical Genetics;
Central Research Institute of Dentistry and Maxillofacial Surgery

Vasilyev A.V.

Central Research Institute of Dentistry and Maxillofacial Surgery;
Research Centre for Medical Genetics

Bukharova T.B.

Research Centre for Medical Genetics

Nedorubova I.A.

Research Centre for Medical Genetics

Goldshtein D.V.

Bochkov Medical and Genetic Research Center

Kulakov A.A.

Central Research Institute of Dentistry and Maxillofacial Surgery

Received:

20.03.2023

Accepted:

10.04.2023

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References:

  1. Deev RV, Drobyshev AY, Bozo IY, Isaev AA. Ordinary and Activated Bone Grafts: Applied Classification and the Main Features. BioMed Res Int. 2015; 2015:1-19.  https://doi.org/10.1155/2015/365050
  2. Menger MM, Stutz J, Ehnert S, Nussler AK, Rollmann MF, Herath SC, Braun BJ, Pohlemann T, Menger MD, Histing T. Development of an Ischemic Fracture Healing Model in Mice. Acta Orthop. 2022;93:466-471.  https://doi.org/10.2340/17453674.2022.2529
  3. Bozo IY, Drobyshev AY, Redko NA, Komlev VS, Isaev AA, Deev RV. Bringing a Gene-Activated Bone Substitute Into Clinical Practice: From Bench to Bedside. Front Bioeng Biotechnol. 2021;9:599300. https://doi.org/10.3389/fbioe.2021.599300
  4. Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, et al. Characterization of the Distinct Orthotopic Bone-Forming Activity of 14 BMPs Using Recombinant Adenovirus-Mediated Gene Delivery. Gene Ther. 2004;11:1312-1320. https://doi.org/10.1038/sj.gt.3302298
  5. Ho SKC, Peel SAF, Hu ZM, Sándor GKB, Clokie CML. Augmentation of the Maxillary Sinus: Comparison of Bioimplants Containing Bone Morphogenetic Protein and Autogenous Bone in a Rabbit Model. J Can Dent Assoc. 2010;76:108. 
  6. Torrecillas-Martinez L, Monje A, Pikos MA, Ortega-Oller I, Suarez F, Galindo-Moreno P, Wang H-L. Effect of RhBMP-2 Upon Maxillary Sinus Augmentation: A Comprehensive Review. Implant Dent. 2013;22:232-237.  https://doi.org/10.1097/ID.0b013e31829262a8
  7. Han JJ, Moon JE, Lee E-H, Yang HJ, Hwang SJ. Clinical and Radiographic Outcomes of Dental Implant after Maxillary Sinus Floor Augmentation with RhBMP-2/Hydroxyapatite Compared to Deproteinized Bovine Bone. PLOS ONE. 2022;17:e0273399. https://doi.org/10.1371/journal.pone.0273399
  8. Vasilyev AV, Kuznetsova VS, Galitsyna EV, Bukharova TB, Osidak EO, Fatkhudinova NL, Leonov GE, Babichenko II, Domogatsky SP, Goldstein DV, et al. Biocompatibility and Osteoinductive Properties of Collagen and Fibronectin Hydrogel Impregnated with RhBMP-2. Stomatologiya. 2019;98:5.  https://doi.org/10.17116/stomat2019980625
  9. Vasilyev AV, Bukharova TB, Kuznetsova VS, Zagoskin YuD, Minaeva SA, Grigoriev T.E, Antonov EN, Osidak EO, Galitsyna EV, Babichenko II, et al. Comparison of Impregnated Bone Morphogenetic Protein-2 Release Kinetics from Biopolymer Scaffolds. Inorg Mater Appl Res. 2019;10:1093-1100. https://doi.org/:10.1134/S2075113319050332
  10. Vasilyev AV, Kuznetsova VS, Bukharova TB, Grigoriev TE, Zagoskin YD, Galitsina EV, Fatkhudinova NL, Babichenko II, Chvalun SN, Goldstein DV, et al. Osteoinductive Potential of Highly Porous Polylactide Granules and Bio-Oss Impregnated with Low Doses of BMP-2. IOP Conf Ser Earth Environ Sci. 2020;421:052035. https://doi.org/10.1088/1755-1315/421/5/052035
  11. Zhao Z, Anselmo AC, Mitragotri S. Viral Vector‐based Gene Therapies in the Clinic. Bioeng Transl Med. 2022;7.  https://doi.org/10.1002/btm2.10258
  12. Kirker-Head CA. Potential Applications and Delivery Strategies for Bone Morphogenetic Proteins. Adv Drug Deliv Rev. 2000;43:65-92.  https://doi.org/10.1016/s0169-409x(00)00078-8
  13. Loh XJ, Lee T-C. Gene Delivery by Functional Inorganic Nanocarriers. Recent Pat. DNA Gene Seq. 2012;6:108-114.  https://doi.org/10.2174/187221512801327361
  14. Huh J-B, Yang J-J, Choi K-H, Bae J, Lee J-Y, Kim S-E, Shin S-W. Effect of RhBMP-2 Immobilized Anorganic Bovine Bone Matrix on Bone Regeneration. Int J Mol Sci. 2015;16:16034-16052. https://doi.org/10.3390/ijms160716034
  15. Park J-C, Bae E-B, Kim S-E, Kim S-Y, Choi K-H, Choi J-W, Bae J-H, Ryu J-J, Huh J-B. Effects of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials with Different Compositions on Bone Regeneration. Materials. 2016;9:954.  https://doi.org/10.3390/ma9110954
  16. Vasilyev AV, Kuznetsova VS, Bukharova TB, Grigoriev TE, Zagoskin YD, Galitsina EV, Fatkhudinova NL, Babichenko II, Chvalun SN, Goldstein DV, et al. Osteoinductive Potential of Highly Porous Polylactide Granules and Bio-Oss Impregnated with Low Doses of BMP-2. IOP Conf. Ser. Earth Environ. Sci. 2020;421:052035. https://doi.org/10.1088/1755-1315/421/5/052035
  17. Edelmayer M, Wehner C, Ulm C, Zechner W, Shafer D, Agis H. Which Substances Loaded onto Collagen Scaffolds Influence Oral Tissue Regeneration? — An Overview of the Last 15 Years. Clin Oral Investig. 2020;24:3363-3394. https://doi.org/10.1007/s00784-020-03520-0
  18. de Freitas RM, Susin C, Spin-Neto R, Marcantonio C, Wikesjö UME, Pereira LAVD, Marcantonio E. Horizontal Ridge Augmentation of the Atrophic Anterior Maxilla Using RhBMP-2/ACS or Autogenous Bone Grafts: A Proof-of-Concept Randomized Clinical Trial. J Clin Periodontol. 2013; 40:968-975.  https://doi.org/10.1111/jcpe.12148
  19. Ramly EP, Alfonso AR, Kantar RS, Wang MM, Siso JRD, Ibrahim A, Coelho PG, Flores RL. Safety and Efficacy of Recombinant Human Bone Morphogenetic Protein-2 (RhBMP-2) in Craniofacial Surgery. Plast Reconstr Surg — Glob Open. 2019;7:e2347. https://doi.org/10.1097/GOX.0000000000002347
  20. Bozo IY, Deev RV, Drobyshev AY, Isaev AA, Eremin II. World’s First Clinical Case of Gene-Activated Bone Substitute Application. Case Rep Dent. 2016;2016:8648949. https://doi.org/10.1155/2016/8648949
  21. Cicciù M, Scott A, Cicciù D, Tandon R, Maiorana C. Recombinant Human Bone Morphogenetic Protein-2 Promote and Stabilize Hard and Soft Tissue Healing for Large Mandibular New Bone Reconstruction Defects: J Craniofac Surg. 2014;25:860-862.  https://doi.org/10.1097/SCS.0000000000000830
  22. Boyne PJ, Lilly LC, Marx RE, Moy PK, Nevins M, Spagnoli DB, Triplett RG. De Novo Bone Induction by Recombinant Human Bone Morphogenetic Protein-2 (RhBMP-2) in Maxillary Sinus Floor Augmentation. J Oral Maxillofac Surg. 2005;63:1693-1707. https://doi.org/10.1016/j.joms.2005.08.018
  23. Judge A, McClintock K, Phelps JR, Maclachlan I. Hypersensitivity and Loss of Disease Site Targeting Caused by Antibody Responses to PEGylated Liposomes. Mol Ther J Am Soc Gene Ther. 2006;13:328-337.  https://doi.org/10.1016/j.ymthe.2005.09.014
  24. Carragee EJ, Hurwitz EL, Weiner BK. A Critical Review of Recombinant Human Bone Morphogenetic Protein-2 Trials in Spinal Surgery: Emerging Safety Concerns and Lessons Learned. Spine J. 2011;11:471-491.  https://doi.org/10.1016/j.spinee.2011.04.023
  25. Sabatino DE, Bushman FD, Chandler RJ, Crystal RG, Davidson BL, Dolmetsch R, Eggan KC, Gao G, Gil-Farina I, Kay MA, et al. Evaluating the State of the Science for Adeno-Associated Virus Integration: An Integrated Perspective. Mol Ther. 2022;30:2646-2663. https://doi.org/10.1016/j.ymthe.2022.06.004
  26. Lee JH, Lee E-N, Nam SH. The Short-Term Effects of Repetitive E. Coli — Derived RhBMP-2 Administration through Intravenous Injection in Rats. Drug Chem Toxicol. 2014;37:40-47.  https://doi.org/10.3109/01480545.2013.806530
  27. Rihn JA, Patel R, Makda J, Hong J, Anderson DG, Vaccaro AR, Hilibrand AS, Albert TJ. Complications Associated with Single-Level Transforaminal Lumbar Interbody Fusion. Spine J Off J North Am Spine Soc. 2009;9:623-629.  https://doi.org/10.1016/j.spinee.2009.04.004
  28. James AW, LaChaud G, Shen J, Asatrian G, Nguyen V, Zhang X, Ting K, Soo C. A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2. Tissue Eng. Part B Rev. 2016;22:284-297.  https://doi.org/10.1089/ten.teb.2015.0357
  29. Wikesjö UME, Qahash M, Polimeni G, Susin C, Shanaman RH, Rohrer MD, Wozney JM, Hall J. Alveolar Ridge Augmentation Using Implants Coated with Recombinant Human Bone Morphogenetic Protein-2: Histologic Observations. J Clin Periodontol. 2008;35:1001-1010. https://doi.org/10.1111/j.1600-051X.2008.01321.x
  30. Hackett NR, El Sawy T, Lee LY, Silva I, O’Leary J, Rosengart TK, Crystal RG. Use of Quantitative TaqMan Real-Time PCR to Track the Time-Dependent Distribution of Gene Transfer Vectors in Vivo. Mol Ther J Am Soc Gene Ther. 2000;2:649-656.  https://doi.org/10.1006/mthe.2000.0203
  31. Vajanto I, Rissanen TT, Rutanen J, Hiltunen MO, Tuomisto TT, Arve K, Närvänen O, Manninen H, Räsänen H, Hippeläinen M, et al. Evaluation of Angiogenesis and Side Effects in Ischemic Rabbit Hindlimbs after Intramuscular Injection of Adenoviral Vectors Encoding VEGF and LacZ. J Gene Med. 2002;4:371-380.  https://doi.org/10.1002/jgm.287
  32. Baltzer AW, Lattermann C, Whalen JD, Braunstein S, Robbins PD, Evans CH. A Gene Therapy Approach to Accelerating Bone Healing. Evaluation of Gene Expression in a New Zealand White Rabbit Model. Knee Surg Sports Traumatol Arthrosc Off J ESSKA. 1999;7:197-202.  https://doi.org/10.1007/s001670050147
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