Systemic toxicity of local anesthetics

Rabinovich S.A.; Zavodilenko L.A.

doi:https://doi.org/10.17116/stomat201796236-42

Rabinovich S.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Zavodilenko L.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Systemic toxicity of local anesthetics

Authors:

Rabinovich S.A., Zavodilenko L.A.

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Journal: Stomatology. 2017;96(2): 36‑42

DOI: 10.17116/stomat201796236-42

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To cite this article:

Rabinovich SA, Zavodilenko LA. Systemic toxicity of local anesthetics. Stomatology. 2017;96(2):36‑42. (In Russ.)
https://doi.org/10.17116/stomat201796236-42

Подписка 2026 Стоматология (Stomatology)

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Abstract:

The paper presents characteristics of local anesthetics used in dentistry and maxillofacial surgery taking into account their effectiveness and toxicity. We described the main clinical symptoms of manifestation of systemic toxicity and measures for prevention of local anesthesia complications, as well as the detailed protocol of «lipid rescue» and resuscitation at manifestation of systemic toxic reaction of local anesthetics with the mechanism of the fatty emulsion action.

Keywords:

dentistry

maxillofacial surgery

local anesthetics

systemic toxicity

«lipid rescue»

Authors:

Rabinovich S.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

Zavodilenko L.A.

Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet

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References:

Koryachkin V.A., Chupris V.G., Chernyi A.Zh., Kazarin V.S., Lis'kov M.A., Malevich G.M., Mal'tsev M.P. Sistemnaya toksichnost' mestnykh anestetikov pri regionarnoi anestezii v ortopedii i travmatologii. Travmatologiya i ortopediya Rossii. 2015;1(75):129-133.
Koryachkin V.A., Emanuel' V.L., Strashnov V.I. Diagnostika v anesteziologii i intensivnoi terapii. SPb.: Spetslit; 2011.
Rabinovich S.A., Zavodilenko L.A., Bodneva S.L., Zagoruiko E.B. Ekstrennaya pomoshch' pri neotlozhnykh sostoyaniyakh v usloviyakh stomatologicheskogo kabineta. Uchebnoe posobie dlya vrachei-stomatologov. Krasnodar. 2016.
Rabinovich S.A., Zoryan E.V., Vasil'ev Yu.P., Pasechnik I.N., Gubaidullin R.R., Skobelev E.I. Obespechenie bezopasnosti pri provedenii mestnoi anestezii v stomatologii. Pervaya pomoshch' pri neotlozhnykh sostoyaniyakh. Uchebno-metodicheskoe posobie. M.: 2014.
Bol'shakov I.N., Baitinger V.F., Rabinovich S.A. Provodnikovaya anesteziya (algoritmy poiska i deistvii). Uchebnoe posobie. M.: Poli Media Press; 2016.
Fesenko V.S. «Serebryanaya pulya» poluchaet priznanie: novye rekomendatsii otnositel'no intoksikatsii mestnymi anestetikami. Meditsina neotlozhnykh sostoyanii. 2011;(7-8):33-45.
Fesenko V.S. Intoksikatsiya mestnymi anestetikami: staraya opasnost', sovremennye mify, novye preparaty i «serebryanaya pulya». Meditsina neotlozhnykh sostoyanii. 2008;4:131-138.
Butterworth JF. Models and mechanisms of local anesthetic cardiac toxicity: a review. Reg Anesth Pain Med. 2010;35(2):167-176.
Ciechanowicz SJ, Patil VK. Association of Anaesthetists of Great Britain and Ireland. Intravenous lipid emulsion — rescued at LAST. Br Dent J. 2012;212(5):237-241.
Di Gregorio G, Neal JM, Rosenquist RW, Weinberg GL. Clinical presentation of local anesthetic systemic toxicity: a review of published cases, 1979 to 2009. Reg Anesth Pain Med. 2010;35(2):181-187.
Ewe P. Sait «lipidnogo spaseniya» [www.lipidrescue.org]
Finucane BT. ed. Complications of regional anesthesia. New York: Springer; 2007.
Neall JM, Mulro MF, Guy L. Weinberg. American Society of Regional Anesthesia and Pain Medicine Checklist for Managing Local Anesthetic Systemic Toxicity: 2012 Version. Reg Anesth Pain Med. 2012;37:7-15.
Mellin-Olsen J, Staender S, Whitaker DK, Smith AF. The Helsinki declaration on patient safety in anaesthesiology. Eur J Anaesthesiol. 2010;27(7):592-597.
Neal JM, Bernards C, Butterworth JF, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL. ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med. 2010;35(2):152-161.
Payrush V, Shchurovska I, Andriyevska N. Clinical cases complication of local anesthesia use during maxillofacial surgery in infants. International Poster Journal of Dentistry and Oral Medicin, 14th International Dental Congress on Anesthesia, Sedation and Pain Control (IFDAS). Berlin. 2016.
Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft J. Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. Anesthesiology. 2006;105(1):217-218.
Szczuruwska I, Pajkusz W, Andrijewska N, Hubycz H, Andrejczuk I. Powiklania znieczulenia miejscowego w trakcie operacji z zakresu chirurgii szczekowo-twarzowej u dzieci w wieku niemowlecym. Anestezjologia Intensywna Terapia. 2011;43(1):38-39.
Weinberg GL. Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose. Anesthesiology. 2012;117(1):180-187.
West PL, McKeown NJ, Hendrickson RG. Iatrogenic lipid emulsion overdose in a case of amlodipine poisoning. Clin Toxicol. 2010;48:393-396.