Scleroatrophic lichen (SAL) is a chronic inflammatory disease of the skin and mucous membranes of unknown etiology. The pathogenesis of SAL is very complex and has not been sufficiently studied to date. The most likely theory is that the disease is autoimmune due to a genetic predisposition. Changes in the vulva, characteristic of SAL, are often an accidental finding due to an asymptomatic course in the initial phase of the disease. Nevertheless, timeous diagnosis of the disease by biopsy is important, as it is often associated with high risks of intraepithelial neoplasia or vulvar cancer. Clinical manifestations of SAL significantly reduce the quality of life of women, therefore, known treatment methods are primarily aimed at reducing them. However, most of the treatment methods used do not have the proper effectiveness, long-term effect, and do not restrain the progressive atrophy and fibrosis of vulvar tissues. The methods of personalized and cellular therapy proposed and considered in the review have not been sufficiently studied from the standpoint of long-term results of treatment of SAL. Heterogeneous collagen-containing compositions of SpheroGEL in various forms of execution, according to the results of numerous conducted in vitro, in vivo and randomized clinical trials, make it possible to carry out regenerative therapy of sebum, significantly reduce the severity of its symptoms and improve the aesthetic perception of patients’ own vulva.