Peculiarities of reproductive tract microbiota in patients with endometrial pathology

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OBJECTIVE

To study the microbiota of the reproductive tract (vagina, uterine cavity) in patients with endometrial hyperplasia and polyps.

MATERIAL AND METHODS

The study included 60 patients: 20 patients with endometrial hyperplasia (group 1), 20 patients with endometrial polyps (group 2) and 20 patients without endometrial pathology (group 3, control group). The microbiota of the reproductive tract was assessed by real-time PCR method using AmpliSens Florocenosis kits.

RESULTS

In patients with endometrial hyperplasia and polyps in the vagina and uterine cavity, an increase in the number of opportunistic microorganisms was observed in the vagina and uterine cavity against the background of a decrease in the content of lactobacilli. Gardnerella vaginalis (35.0 and 10.0% respectively) and Ureaplasma parvum (55.0 and 10.0% respectively) were detected in the vagina of group 1 patients significantly more often than in group 3 patients against the background of a 1.2-fold decrease in the number of lactobacilli. Gardnerella vaginalis (40.0 and 10.0%, respectively) and Staphylococcus spp. (70.0 and 30.0%, respectively) were detected in the vagina of group 2 patients significantly more often than in group 3 patients against the background of a 2-fold decrease in the number of lactobacilli.

CONCLUSION

Prevention of endometrial pathology consists not only of timely detection of anovulation and its prevention, correction of endocrine disorders, but also treatment of patients with dysbiosis of female genital organs.

Keywords:

endometrial hyperplasia

endometrial polyp

reproductive tract microbiota

microflora disturbance in endometrial pathology

Authors:

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

SPIN RSCI: 2925-9948
Scopus AuthorID: 57188592250
ORCID: 0000-0002-7830-2290

Salamova K.K.

N.I. Pirogov Russian National Research Medical University

ORCID: 0000-0003-1137-5492

Received:

27.07.2023

Accepted:

18.08.2023

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