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Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Salamova K.K.

N.I. Pirogov Russian National Research Medical University

Peculiarities of reproductive tract microbiota in patients with endometrial pathology

Authors:

Dobrokhotova Yu.E., Salamova K.K.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2023;23(6‑2): 107‑113

DOI: 10.17116/rosakush202323062107

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Table of contents

PECULIARITIES OF REPRODUCTIVE TRACT MICROBIOTA IN PATIENTS WITH ENDOMETRIAL PATHOLOGY
PECULIARITIES OF REPRODUCTIVE TRACT MICROBIOTA IN PATIENTS WITH ENDOMETRIAL PATHOLOGY

To cite this article:

Dobrokhotova YuE, Salamova KK. Peculiarities of reproductive tract microbiota in patients with endometrial pathology. Russian Bulletin of Obstetrician-Gynecologist. 2023;23(6‑2):107‑113. (In Russ.)
https://doi.org/10.17116/rosakush202323062107

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To study the microbiota of the reproductive tract (vagina, uterine cavity) in patients with endometrial hyperplasia and polyps.

MATERIAL AND METHODS

The study included 60 patients: 20 patients with endometrial hyperplasia (group 1), 20 patients with endometrial polyps (group 2) and 20 patients without endometrial pathology (group 3, control group). The microbiota of the reproductive tract was assessed by real-time PCR method using AmpliSens Florocenosis kits.

RESULTS

In patients with endometrial hyperplasia and polyps in the vagina and uterine cavity, an increase in the number of opportunistic microorganisms was observed in the vagina and uterine cavity against the background of a decrease in the content of lactobacilli. Gardnerella vaginalis (35.0 and 10.0% respectively) and Ureaplasma parvum (55.0 and 10.0% respectively) were detected in the vagina of group 1 patients significantly more often than in group 3 patients against the background of a 1.2-fold decrease in the number of lactobacilli. Gardnerella vaginalis (40.0 and 10.0%, respectively) and Staphylococcus spp. (70.0 and 30.0%, respectively) were detected in the vagina of group 2 patients significantly more often than in group 3 patients against the background of a 2-fold decrease in the number of lactobacilli.

CONCLUSION

Prevention of endometrial pathology consists not only of timely detection of anovulation and its prevention, correction of endocrine disorders, but also treatment of patients with dysbiosis of female genital organs.

Keywords:

endometrial hyperplasia
endometrial polyp
reproductive tract microbiota
microflora disturbance in endometrial pathology

Authors:

Dobrokhotova Yu.E.

Pirogov Russian National Research Medical University

Salamova K.K.

N.I. Pirogov Russian National Research Medical University

Received:

27.07.2023

Accepted:

18.08.2023

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