Current therapy for patients with peri- and post-menopausal vulvovaginal atrophy. (Experience of clinical application)

Shalina M.A.; Lisyanskaya M.V.; Nesterov I.M.

doi:https://doi.org/10.17116/rosakush202222051100

Shalina M.A.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology

ORCID: 0000-0002-5921-3217

Lisyanskaya M.V.

Pirogov Clinic

Nesterov I.M.

I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia

Current therapy for patients with peri- and post-menopausal vulvovaginal atrophy. (Experience of clinical application)

Authors:

Shalina M.A., Lisyanskaya M.V., Nesterov I.M.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2022;22(5): 100‑103

DOI: 10.17116/rosakush202222051100

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To cite this article:

Shalina MA, Lisyanskaya MV, Nesterov IM. Current therapy for patients with peri- and post-menopausal vulvovaginal atrophy. (Experience of clinical application). Russian Bulletin of Obstetrician-Gynecologist. 2022;22(5):100‑103. (In Russ.)
https://doi.org/10.17116/rosakush202222051100

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

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OBJECTIVE OF THE STUDY

To compare the efficacy and safety of two different application regimens of Multi-Gyn LiquidGel vaginal gel for relief of vulvovaginal atrophy symptoms in peri- and postmenopausal females.

MATERIAL AND METHODS

A total of 60 female patients with symptoms of genitourinary menopausal syndrome participated in the post-registration study. All patients were randomized into two groups: Group 1 comprised 30 patients who received Multi-Gyn LiquiGel intravaginally 2 mg once daily for 21 days, Group 2 comprised 30 patients who received Multi-Gyn LiquiGel intravaginally 2 mg twice daily for 21 days. The study duration was 28 days. According to the study design, the patients had 4 visits at 7-day intervals each. At the 0th, 1st, 2nd and 3rd visits, the degree of vulvovaginal atrophy was assessed using a visual analogue scale. The Multi-Gyn LiquiGel regimen in Groups 1 and 2 was according to the instructions. The efficacy of the therapy was assessed by the value of the vaginal pH, the vaginal maturation index, the vaginal health index, the visual analogue scale, the Barlow scale, and the achievement of normal flora of the genital tract.

RESULTS

The application of topical treatment with Multi-Gyn LiquiGel intravaginally in female patients with symptoms of vulvovaginal atrophy in the peri- and post-menopause periods was highly effective in both groups. No significant difference in the efficacy of the two different treatment regimens was found.

CONCLUSION

The Multi-Gyn LiquiGel has been shown to be highly effective in patients with atrophic vulvovaginitis symptoms in both groups. The best and fastest results were achieved in younger patients with preserved menstrual cycle and mild symptoms of atrophy.

Keywords:

vulvovaginal atrophy

genitourinary menopausal syndrome

perimenopause

postmenopause

Authors:

Shalina M.A.

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology

ORCID: 0000-0002-5921-3217

Lisyanskaya M.V.

Pirogov Clinic

Nesterov I.M.

I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Healthcare of Russia

Received:

12.09.2022

Accepted:

19.09.2022

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