Objective — to study the range of biologically active substances in blood of obstetric patients, which provide conditions for the formation of the fetal tissues, and to determine the degree of their impact on the development of intrauterine growth restriction. Material and methods. Ninety seven pregnant women with full-term pregnancy were examined. They were divided into two groups. Group 1 (treatment group) contained 47 patients with intrauterine growth restriction. Group 2 (reference group) contained 50 pregnant women without intrauterine growth restriction. The diagnosis «Intrauterine growth restriction» was made on the basis of clinical laboratory examinations of the pregnant women and confirmed at the assessment of the new-born state. A study material was serum obtained from blood taken in the first period of the term birth; the content of cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C), α-fetoprotein were determined on a biochemical analyzer; α-1-microglobulin, TLR-4 (toll-like receptor 4), insulin receptor, lumican, and TNFα (tumour necrosis factor-α) were determined by immunoenzymometric method based on a sensitive sandwich assay. Results. Biochemical criteria of intrauterine growth restriction and their role in metabolism were revealed in blood serum of pregnant women among biologically active cellular regulators. The reduction of the contents of cholesterol, LDL-C, α-fetoprotein and the increase of the levels of insulin receptors, α1-microglobulin, and lumican in blood serum of women provide for the metabolic situation that breaks the necessary conditions for the tissue formation of the developing fetus, thus being the reason of growth restriction. Conclusion. The conducted study gives a clear understanding of the presence of the modification of biochemical processes participating in cholesterol transport to the fetus in women with intrauterine growth restriction, thus resulting in the disturbance of the synthesis of its cell membranes and causing this pathology.