Despite the good biocompatibility and inertness of current mesh implants, the number of implant-related complications increases in parallel with the rise in the number of operations performed. In this connection, it is important to experimentally clarify exactly what the occurring complications are related to. Objective — to experimentally study the features of tissue reactions to the abdominal administration of suspension from a synthetic polypropylene-based mesh implant for minimal surgical trauma. Material and methods. A procedure was proposed, which consisted in that a cryostat-frozen implant fragment was crushed with a microtome to particles less than 10 µm, dried, sterilized, resuspended in a sterile isotonic sodium chloride solution and intraperitoneally injected into small laboratory mice with a syringe, and then the indicators of the functional activity of various biologically active substances were studied. This makes it possible to reliably assess the response of an experimental animal to the inserted mesh implant. The study was conducted in female hybrid mice. An experimental group consisted of 30 mice that received 2 ml of intraperitoneal suspension with a synthetic mesh implant. Control mice (n=30) were injected with the same volume of isotonic sodium chloride solution. Animals were withdrawn from the experiment at 20, 40, and 60 days. Results. A significant (25%) decrease in the phagocytic index was recorded at day 20 after administering the suspension containing the crushed polypropylene mesh. The used method showed no exceeding sensitivity values (25 pg/ml) for interleukins (IL-1 and IL-5) in any lavage liquid sample. Elevated lavage fluid IL-4, IL-6, IL-22, and interferon-γ levels were found only in individual animals. Conclusion. There was evidence that the synthetic material showed a good biocompatibility and inertness. At the same time, the moderate local immunosuppressive effect of an implant may suggest that the deviations during more traumatic surgical procedures than under experimental conditions will increase the risk of complications. In addition, the degree of the detected local immunosuppressive effect of the implant may depend on the characteristics of tissues at the time of surgery. At the same time, the procedure that allows collection of the resultant exudate at any postoperative stage can be also used for other purposes and tasks.