Clinicomorphological rationale for treatment optimization in patients with endometrial hyperplasia

Klinyshkova T.V.

Kafedra akusherstva i ginekologii fakul'teta poslediplomnogo obrazovaniia

Frolova N.B.

Kafedra akusherstva i ginekologii fakul'teta poslediplomnogo obrazovaniia

Mozgovoĭ S.I.

Kafedra patologicheskoĭ anatomii Omskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Clinicomorphological rationale for treatment optimization in patients with endometrial hyperplasia

Authors:

Klinyshkova T.V., Frolova N.B., Mozgovoĭ S.I.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2010;10(3): 16‑20

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To cite this article:

Klinyshkova TV, Frolova NB, Mozgovoĭ SI. Clinicomorphological rationale for treatment optimization in patients with endometrial hyperplasia. Russian Bulletin of Obstetrician-Gynecologist. 2010;10(3):16‑20. (In Russ.)

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)

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Forty-three patients with simple endometrial hyperplasia (EH) (Group 1) and complex EH without atypia (Group 2) were examined to improve management tactics for this condition in reproductive-aged and premenopausal women. Along with traditional studies, the authors performed an immunohistochemical study of the expression of α-estrogen and progesterone receptors (ER and PR) and the proliferation marker Ki-67 in the epithelium of endometrial glands and stromal cells. There was a decrease in ER levels (p < 0.05) with moderate endometrial proliferation in Groups 1 and 2 and a maximal reduction in the immunohistochemical index for PR in complex EH as compared with those in the control group (p < 0.05). Receptor expression was characterized by a predominance of PR over ER in Groups 1 and 2 (p < 0.05). The specific features of therapeutic approaches for EH have been warranted.

Keywords:

endometrial hyperplasia

α-estrogen receptors

progesterone receptors

Authors:

Klinyshkova T.V.

Kafedra akusherstva i ginekologii fakul'teta poslediplomnogo obrazovaniia

Frolova N.B.

Kafedra akusherstva i ginekologii fakul'teta poslediplomnogo obrazovaniia

Mozgovoĭ S.I.

Kafedra patologicheskoĭ anatomii Omskoĭ gosudarstvennoĭ meditsinskoĭ akademii

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